Enhancement of solubility and dissolution rate of cryptotanshinone, tanshinone i and tanshinone IIA extracted from Salvia miltiorrhiza

Archives of Pharmacal Research

Volumn 35, Issue 8, 2012, Pages 1457-1464

  Yu, Hang ^a   Subedi, Robhash Kusam ^a   Nepal, Pushp R ^a   Kim, Yoon G ^b   Choi, Hoo Kyun ^a  

^a Chosun University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Herbal medicines; Poloxamer 407; Poor water solubility; Povidone K 30; Solid dispersion; Tanshinones

Indexed keywords

ANTIINFLAMMATORY AGENT; CRYPTOTANSHINONE; DRUG CARRIER; POLOXAMER; POVIDONE; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE I; TANSHINONE IIA;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; MALE; NONHUMAN; RAT; SALVIA MILTIORRHIZA;

ANIMALS; AREA UNDER CURVE; DITERPENES, ABIETANE; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; MALE; PHENANTHRENES; PLANT EXTRACTS; POLOXAMER; POVIDONE; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; SOLUBILITY; SOLVENTS; TABLETS;

EID: 84868151672     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0816-1     Document Type: Article

References (18)

1. Chu, M. Q., Gu, H. C., and Liu, G. J., Stability of solid dispersion of tanshinone. J. East Chin. Univ. Sci. Technol., 28, 107-109 (2002).
2. Craig, D. Q. M., The mechanism of drug release from solid dispersions in water-soluble polymers. Int. J. Pharm., 231, 131-144 (2002). (Pubitemid 34033673)
3. Gibaldi, M. and Perrier, D., Pharmacokinetics, 2nd Ed, Marcel Dekker, NY, (1982).
4. Hu, P., Luo, G. A., Zhao, Z. Z., and Jiang, Z. H., Quality assessment of Radix Salviae Miltiorrhizae. Chem. Pharm. Bull., 53, 481-486 (2005). (Pubitemid 40740613)
5. Junghanns, J. U. A. H. And Müller, R. H., Nanocrystals technology, drug delivery and clinical applications. Int. J. Nanomed., 3, 295-309 (2008).
6. Karavas, E., Georgarakis, E., Sigalas, M. P., Avgoustakis, K., and Bikiaris, D., Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. Eur. J. Pharm. Biopharm., 66, 334-347 (2007). (Pubitemid 46778978)
7. Keck, C. M. and Müller, R. H., Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. Eur. J. Pharm. Biopharm., 62, 3-16 (2006). (Pubitemid 41736019)
8. Kim. K. T., Lee J. Y., Lee, M. Y., Song, C. K., Choi, J., and Kim, D., Solid dispersions as a drug delivery system. J. Pharm. Invest., 41, 125-142 (2011).
9. Li, J. F., Wei, Y. X., Ding, L. H., and Dong, C., Study on the inclusion complexes of cryptotanshinone with β-cyclodextrin and hydroxypropyl-β- cyclodextrin. Spectrochim. Acta A Mol. Biomol. Spectrosc., 59, 2759-2766 (2003).
10. Li, X. L., Li, X. R., Wang, L. J., Li, Y. H., Xu, Y. X., and Xue, M., Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang. J. Pharm. Biomed. Anal., 44, 1106-1112 (2007). (Pubitemid 47239299)
11. Ling, W., Xuehua, J., Weijuan, X., and Chenrui, L., Complexation of tanshinone IIA with 2-hydroxypropyl-β-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats. Int. J. Pharm., 341, 58-67 (2007).
12. Luo, X. and Xu, Y. H., Preparation of cryptotanshinone solid dispersion and its properties. Zhong Cao Yao, 36, 839-842 (2005).
13. Passerini, N., Gonzalez-Rodriguez, M. L., Cavallari, C., Rodriguez, L., and Albertini, B., Preparation and characterization of ibuprofen-poloxamer 188 granules obtained by melt granulation. Eur. J. Pharm. Sci., 15, 71-78 (2002). (Pubitemid 34136970)
14. Sethia, S. and Squillante, E., Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int. J. Pharm., 272, 1-10 (2004). (Pubitemid 38293005)
15. Shi, Z. H., He, J. T., Yao, T. T., Chang, W. B., and Zhao, M. P., Simultaneous determination of cryptotanshinone, tanshinone I and tanshinone IIA in traditional Chinese medicinal preparations containing Radix Salvia Miltiorrhiza by HPLC. J. Pharm. Biomed. Anal., 37, 481-486 (2005).
16. Song, M., Hang, T. J., Zhang, Z. X., and Chen, H. Y., Effects of the coexisting deterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur. J. Pharm. Sci., 32, 247-253 (2007). (Pubitemid 350051887)
17. Su, Y. L., Fu, Z. Y., Zhang, J. Y., Wang, W. M., Wang, H., Wang, Y. C., and Zhang, Q. J., Microencapsulation of Radix salvia miltiorrhiza nanoparticles by spray-drying. Powder Technol., 184, 114-121 (2008). (Pubitemid 351514764)
18. Van den Mooter, G., Augustijns, P., Blaton, N., and Kinget, R., Physico-chemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. Int. J. Pharm., 164, 67-80 (1998). (Pubitemid 28160099)