Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Pathi, Satya ^a   Jutooru, Indira ^a   Chadalapaka, Gayathri ^a   Nair, Vijayalekshmi ^a   Lee, Syng Ook ^b   Safe, Stephen ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLIN D1; PROTEIN BCL 2; SCATTER FACTOR RECEPTOR; SURVIVIN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRANSCRIPTION FACTOR SP4; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; ZINC ION; ZINC SULFATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE PRODUCT; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; ASPIRIN; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; SP TRANSCRIPTION FACTORS; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; SP4 TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 84868146644     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048208     Document Type: Article

References (40)

1. Langley RE, Burdett S, Tierney JF, Cafferty F, Parmar MK, et al. (2011) Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy? Br J Cancer 105: 1107-1113.
2. Baron JA, (2003) Epidemiology of non-steroidal anti-inflammatory drugs and cancer. Prog Exp Tumor Res 37: 1-24.
3. Elwood PC, Gallagher AM, Duthie GG, Mur LA, Morgan G, (2009) Aspirin, salicylates, and cancer. Lancet 373: 1301-1309.
4. Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, et al. (2003) A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 348: 883-890.
5. Chan AT, Ogino S, Fuchs CS, (2009) Aspirin use and survival after diagnosis of colorectal cancer. JAMA 302: 649-658.
6. Jacobs EJ, Thun MJ, Bain EB, Rodriguez C, Henley SJ, et al. (2007) A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. J Natl Cancer Inst 99: 608-615.
7. Din FV, Theodoratou E, Farrington SM, Tenesa A, Barnetson RA, et al. (2010) Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut 59: 1670-1679.
8. Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D, et al. (2010) Aspirin intake and survival after breast cancer. J Clin Oncol 28: 1467-1472.
9. Kim KM, Song JJ, An JY, Kwon YT, Lee YJ, (2005) Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem 280: 41047-41056.
10. Borthwick GM, Johnson AS, Partington M, Burn J, Wilson R, et al. (2006) Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. FASEB J 20: 2009-2016.
11. Shtivelband MI, Juneja HS, Lee S, Wu KK, (2003) Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. J Thromb Haemost 1: 2225-2233.
12. Bos CL, Kodach LL, van den Brink GR, Diks SH, van Santen MM, et al. (2006) Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene 25: 6447-6456.
13. Din FV, Stark LA, Dunlop MG, (2005) Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency. Br J Cancer 92: 1137-1143.
14. Din FV, Dunlop MG, Stark LA, (2004) Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. Br J Cancer 91: 381-388.
15. Stark LA, Reid K, Sansom OJ, Din FV, Guichard S, et al. (2007) Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28: 968-976.
16. Hagos GK, Carroll RE, Kouznetsova T, Li Q, Toader V, et al. (2007) Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Mol Cancer Ther 6: 2230-2239.
17. Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, et al. (2011) GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Mol Cancer Res 9: 195-202.
18. Abdelrahim M, Baker CH, Abbruzzese JL, Safe S, (2006) Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. J Natl Cancer Inst 98: 855-868.
19. Abdelrahim M, Safe S, (2005) Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Mol Pharmacol 68: 317-329.
20. Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, et al. (2009) Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. Int J Cancer 125: 1965-1974.
21. Abdelrahim M, Smith R 3rd, Burghardt R, Safe S, (2004) Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Res 64: 6740-6749.
22. Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, et al. (2008) Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 68: 5345-5354.
23. Chadalapaka G, Jutooru I, Burghardt R, Safe S, (2010) Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Mol Cancer Res 8: 739-750.
24. Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, et al. (2010) Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Mol Pharmacol 78: 226-236.
25. Jutooru I, Chadalapaka G, Lei P, Safe S, (2010) Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. J Biol Chem 285: 25332-25344.
26. Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, et al. (2010) Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res 316: 2174-2188.
27. Juarez Olguin H, Flores Perez J, Lares Asseff I, Loredo Abdala A, Carbajal Rodriguez L, (2004) Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases. Biopharm Drug Dispos 25: 1-7.
28. Nollet F, Berx G, Molemans F, van Roy F, (1996) Genomic organization of the human beta-catenin gene (CTNNB1). Genomics 32: 413-424.
29. Yurochko AD, Mayo MW, Poma EE, Baldwin AS Jr, Huang ES, (1997) Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters. J Virol 71: 4638-4648.
30. Wang YT, Chuang JY, Shen MR, Yang WB, Chang WC, et al. (2008) Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process. J Mol Biol 380: 869-885.
31. Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S, (2011) Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and-independent downregulation of specificity proteins (Sp) transcription factors. BMC Cancer 11: 371.
32. Chimienti F, Seve M, Richard S, Mathieu J, Favier A, (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochem Pharmacol 62: 51-62.
33. Seve M, Chimienti F, Richard S, Mathieu J, Favier A (2000) Intracellular zinc chelation induces apoptosis, caspases activation, and transcription factors degradation in Jurkat and HeLa cells. In: Roussel AM, Favier AE, Anderson RA, editors. Trace Elements in Man and Animals 10. New York: Kluwer Academic/Plenum Publishers. 1003-1007.
34. Hunt RH, Lanas A, Stichtenoth DO, Scarpignato C, (2009) Myths and facts in the use of anti-inflammatory drugs. Ann Med 41: 423-437.
35. Chintharlapalli S, Papineni S, Ramaiah SK, Safe S, (2007) Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res 67: 2816-2823.
36. Piedrafita FJ, Pfahl M, (1997) Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Mol Cell Biol 17: 6348-6358.
37. Baslas RK, Zamani R, Nomani AA, (1979) Studies on the metal-complex of acetyl salicylic acid (aspirin). Experientia 35: 455-456.
38. Kim EY, Chang SY, Chung JM, Ryu BR, Joo CK, et al. (2001) Attenuation of Zn2+ neurotoxicity by aspirin: role of N-type Ca2+ channel and the carboxyl acid group. Neurobiol Dis 8: 774-783.
39. Saito H, Sakai T, Ueno K, Kitagawa H, (1982) Influence of maternal drug metabolism on the fetal toxicity induced by acetylsalicylic acid. J Toxicol Sci 7: 177-184.
40. Ghezzo F, Cesano L, Mognetti B, Pesce E, Pirro E, et al. (2005) Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration. Int J Oncol 26: 697-702.