Utility of hepatocyte nuclear factor-1β as a diagnostic marker in ovarian carcinomas with clear cells

Histopathology

Volumn 61, Issue 5, 2012, Pages 760-768

  Kao, Yu Chien ^a   Lin, Ming Chieh ^b   Lin, Wei Chou ^b   Jeng, Yung Ming ^b   Mao, Tsui Lien ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Epithelial ovarian cancer; Hepatocyte nuclear factor 1 (HNF 1 ); Ovarian clear cell carcinoma

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1BETA; TUMOR MARKER;

ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CLEAR CELL CARCINOMA; CONTROLLED STUDY; CYTOPLASM; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOID CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM;

ADENOCARCINOMA, CLEAR CELL; CARCINOMA, ENDOMETRIOID; CARCINOMA, HEPATOCELLULAR; CARCINOMA, RENAL CELL; CYSTADENOCARCINOMA, SEROUS; FEMALE; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; LIVER NEOPLASMS; OVARIAN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84868126411     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2012.04267.x     Document Type: Article

References (26)

1. Igarashi P, Shao X, McNally BT, Hiesberger T. Roles of HNF-1β in kidney development and congenital cystic diseases. Kidney Int. 2005; 68; 1944-1947.
2. Bohn S, Thomas H, Turan G et al. Distinct molecular and morphogenetic properties of mutations in the human HNF1β gene that lead to defective kidney development. J. Am. Soc. Nephrol. 2003; 14; 2033-2041.
3. Coffinier C, Gresh L, Fiette L et al. Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β. Development 2002; 129; 1829-1838.
4. Pontoglio M. Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis. J. Am. Soc. Nephrol. 2000; 11(Suppl. 16); S140-S143.
5. Tsuchiya A, Sakamoto M, Yasuda J et al. Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1ß as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am. J. Pathol. 2003; 163; 2503-2512.
6. Schwartz DR, Kardia SL, Shedden KA et al. Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res. 2002; 62; 4722-4729.
7. Kato N, Sasou S, Motoyama T. Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. Mod. Pathol. 2006; 19; 83-89.
8. Kato N, Toukairin M, Asanuma I, Motoyama T. Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma. Diagn. Cytopathol. 2007; 35; 193-197.
9. Higashiguchi A, Yamada T, Susumu N et al. Specific expression of hepatocyte nuclear factor-1b in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis. Cancer Sci. 2007; 98; 387-391.
10. Kobel M, Kalloger SE, Carrick J et al. A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. Am. J. Surg. Pathol. 2009; 33; 14-21.
11. Young RH, Scully RE. Oxyphilic clear cell carcinoma of the ovary. A report of nine cases. Am. J. Surg. Pathol. 1987; 11; 661-667.
12. Anderson MC, Langley FA. Mesonephroid tumours of the ovary. J. Clin. Pathol. 1970; 23; 210-218.
13. Kurman RJ, Craig JM. Endometrioid and clear cell carcinoma of the ovary. Cancer 1972; 29; 1653-1664.
14. Han G, Gilks CB, Leung S et al. Mixed ovarian epithelial carcinomas with clear cell and serous components are variants of high-grade serous carcinoma: an interobserver correlative and immunohistochemical study of 32 cases. Am. J. Surg. Pathol. 2008; 32; 955-964.
15. Silva EG, Young RH. Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type. Am. J. Surg. Pathol. 2007; 31; 1203-1208.
16. Shih Ie M, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am. J. Pathol. 2004; 164; 1511-1518.
17. Fountain J, Trimble E, Birrer MJ. Summary and discussion of session recommendations. Gynecol. Oncol. 2006; 103(2 Suppl. 1); S23-S25.
18. Tavasolli FA, Devilee P. World Health Organization classification of tumours. Tumours of the breast and the female genital organs. Lyon: IARC Press, 2003.
19. Yamamoto S, Tsuda H, Aida S, Shimazaki H, Tamai S, Matsubara O. Immunohistochemical detection of hepatocyte nuclear factor 1β in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium. Hum. Pathol. 2007; 38; 1074-1080.
20. Ho CM, Huang YJ, Chen TC et al. Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxel-platinum-based chemotherapy in pure-type advanced disease. Gynecol. Oncol. 2004; 94; 197-203.
21. Chew I, Soslow RA, Park KJ. Morphologic changes in ovarian carcinoma after neoadjuvant chemotherapy: report of a case showing extensive clear cell changes mimicking clear cell carcinoma. Int. J. Gynecol. Pathol. 2009; 28; 442-446.
22. Prowse AH, Manek S, Varma R et al. Molecular genetic evidence that endometriosis is a precursor of ovarian cancer. Int. J. Cancer 2006; 119; 556-562.
23. Sato N, Tsunoda H, Nishida M et al. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res. 2000; 60; 7052-7056.
24. Zorn KK, Bonome T, Gangi L et al. Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Clin. Cancer Res. 2005; 11; 6422-6430.
25. Kim L, Liao J, Zhang M et al. Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1beta. Mod. Pathol. 2008; 21; 1075-1083.
26. Xu J, Capezzone M, Xu X, Hershman JM. Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1β in human papillary thyroid cancer cells. Mol. Endocrinol. 2005; 19; 527-539.