Selective nodal irradiation of regionally advanced non-small-cell lung cancer with proton therapy and IMRT: A dosimetric comparison

Thoracic Cancer

Volumn 3, Issue 2, 2012, Pages 169-174

  Nichols, Romaine C ^a   Huh, Soon H ^a   Henderson, Randal H ^a   Li, Zuofeng ^a   Flampouri, Stella ^a   D'Agostino, Harry J ^b   Cury, James D ^b   Pham, Dat C ^b   Mendenhall, Nancy P ^a   Hoppe, Bradford S ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Elective nodal irradiation; Non small cell lung cancer; Normal tissue sparing; Proton therapy

Indexed keywords

EID: 84868117028     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/j.1759-7714.2011.00100.x     Document Type: Article

References (22)

1. Rosenzweig KE, Fox JL, Yorke E et al. Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma. Cancer 2005; 103: 2118-27.
2. Bradley J,Graham MV,Winter K et al. Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 2005; 61: 318-28.
3. Hayman JA,Martel MK, Ten Haken RK et al. Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial. J Clin Oncol 2001; 19: 127-36.
4. Chapet O, Kong FM, Quint LE et al. CT-based definition of thoracic lymph node stations: an atlas from the University of Michigan. Int J Radiat Oncol Biol Phys 2005; 63: 170-8.
5. Nichols RC,Huh SN,Henderson RH et al. Proton radiation therapy offers reduced normal lung and bone marrow exposure for patients receiving dose-escalated radiation therapy for unresectable stage III non-small-cell lung cancer: a dosimetric study. Clin Lung Cancer 2011; 12: 252-7.
6. Chang JY, Zhang X,Wang X et al. Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2006; 65: 1087-96.
7. Sejpal S, Komaki R, Tsao A et al. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer. Cancer 2011; 117: 3004-13.
8. Hoppe BS, Flampouri S, Pham D et al. Technique and early outcomes of proton therapy with concurrent chemotherapy for lung cancer. J Thorac Oncol 2010; 5 (Suppl.): S563.
9. Nichols RC,Huh SH,Hoppe BS,Henderson RH, Li Z, FLampouri S, et al. Protons Safely Allow Coverage of High Risk Nodes for PatientsWith Regionally Advanced NSCLC. Technol Cancer Res Treat 2011; 10:317-22.
10. Kelsey CR,Marks LB, Glatstein E. Elective nodal irradiation for locally advanced non-small-cell lung cancer: it's called cancer for a reason. Int JRadiat Oncol Biol Phys 2009; 73: 1291-2.
11. Bradley JD,Moughan J,GrahamMV et al. A phase I/II radiation dose escalation study with concurrent chemotherapy for patients with inoperable stages I to III non-small-cell lung cancer: phase I results of RTOG 0117. Int J Radiat Oncol Biol Phys 2010; 77: 367-72.
12. Rosenzweig KE, Sura S, Jackson A, Yorke E. Involved-field radiation therapy for inoperable non small-cell lung cancer. J Clin Oncol 2007; 25: 5557-61.
13. Belderbos JS,Heemsbergen WD, De Jaeger K, Baas P, Lebesque JV. Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2006; 66: 126-34.
14. Yuan S, Sun X, LiMet al. A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer. Am J Clin Oncol 2007; 30: 239-44.
15. Kepka L,Maciejewski B,Withers RH. Does incidental irradiation with doses below 50 Gy effectively reduce isolated nodal failures in non-small-cell lung cancer: dose-response relationship. Int J Radiat Oncol Biol Phys 2009; 73: 1391-6.
16. Kimura T, Togami T,Nishiyama Y, Ohkawa M, Takashima H. Impact of incidental irradiation on clinically uninvolved nodal regions in patients with advanced non-small-cell lung cancer treated with involved-field radiation therapy: does incidental irradiation contribute to the low incidence of elective nodal failure? Int J Radiat Oncol Biol Phys 2010; 77: 337-43.
17. KimBT, Lee KS, Shim SS et al. Stage T1 non-small cell lung cancer: preoperativemediastinal nodal staging with integrated FDG PET/CT - a prospective study. Radiology 2006; 241: 501-9.
18. Al-Sarraf N, Aziz R, Gately K et al. Pattern and predictors of occult mediastinal lymph node involvement in non-small cell lung cancer patients with negative mediastinal uptake on positron emission tomography. Eur J Cardiothorac Surg 2008; 33: 104-9.
19. Videtic GM,Rice TW,Murthy S et al. Utility of positron emission tomography compared with mediastinoscopy for delineating involved lymph nodes in stage III lung cancer: insights for radiotherapy planning from a surgical cohort. Int J Radiat Oncol Biol Phys 2008; 72: 702-6.
20. Socinski MA,Morris DE,Halle JS et al. Induction and concurrent chemotherapy with high-dose thoracic conformal radiation therapy in unresectable stage IIIA and IIIB non-small-cell lung cancer: a dose-escalation phase I trial. J Clin Oncol 2004; 22: 4341-50.
21. Rosenman JG,Halle JS, Socinski MA et al. High-dose conformal radiotherapy for treatment of stage IIIA/IIIB non-small-cell lung cancer: technical issues and results of a phase I/II trial. Int J Radiat Oncol Biol Phys 2002; 54: 348-56.
22. Chang JY, Komaki R, Lu C et al. Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III nonsmall cell lung cancer. Cancer 2011; doi: 10.1002/cncr.26080.