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Volumn 64, Issue 11, 2012, Pages 3809-3817

Increased expression of vascular cell adhesion molecule 1 in muscle biopsy samples from juvenile dermatomyositis patients with short duration of untreated disease is regulated by miR-126

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MICRORNA 126; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

EID: 84868103669     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34606     Document Type: Article
Times cited : (45)

References (43)
  • 1
    • 0038651973 scopus 로고    scopus 로고
    • US incidence of juvenile dermatomyositis, 1995-1998: Results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry
    • for the NIAMS Juvenile DM Registry Physician Referral Group
    • Mendez EP, Lipton R, Ramsey-Goldman R, Roettcher P, Bowyer S, Dyer A, et al, for the NIAMS Juvenile DM Registry Physician Referral Group. US incidence of juvenile dermatomyositis, 1995-1998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry. Arthritis Rheum 2003; 49: 300-5.
    • (2003) Arthritis Rheum , vol.49 , pp. 300-305
    • Mendez, E.P.1    Lipton, R.2    Ramsey-Goldman, R.3    Roettcher, P.4    Bowyer, S.5    Dyer, A.6
  • 2
    • 0016850495 scopus 로고
    • Polymyositis and dermatomyositis (first of two parts)
    • Bohan A, Peter JB,. Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975; 292: 344-7.
    • (1975) N Engl J Med , vol.292 , pp. 344-347
    • Bohan, A.1    Peter, J.B.2
  • 3
    • 0013932378 scopus 로고
    • Dermatomyositis (systemic angiopathy) of childhood
    • Banker BQ, Victor M,. Dermatomyositis (systemic angiopathy) of childhood. Medicine (Baltimore) 1966; 45: 261-89.
    • (1966) Medicine (Baltimore) , vol.45 , pp. 261-289
    • Banker, B.Q.1    Victor, M.2
  • 5
    • 39749198188 scopus 로고    scopus 로고
    • Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis
    • Christen-Zaech S, Seshadri R, Sundberg J, Paller AS, Pachman LM,. Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis. Arthritis Rheum 2008; 58: 571-6.
    • (2008) Arthritis Rheum , vol.58 , pp. 571-576
    • Christen-Zaech, S.1    Seshadri, R.2    Sundberg, J.3    Paller, A.S.4    Pachman, L.M.5
  • 6
    • 3442893826 scopus 로고    scopus 로고
    • Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loops
    • Smith RL, Sundberg J, Shamiyah E, Dyer A, Pachman LM,. Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loops. J Rheumatol 2004; 31: 1644-9.
    • (2004) J Rheumatol , vol.31 , pp. 1644-1649
    • Smith, R.L.1    Sundberg, J.2    Shamiyah, E.3    Dyer, A.4    Pachman, L.M.5
  • 7
    • 39449109120 scopus 로고    scopus 로고
    • Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositis
    • Rouster-Stevens KA, Gursahaney A, Ngai KL, Daru JA, Pachman LM,. Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositis. Arthritis Rheum 2008; 59: 222-6.
    • (2008) Arthritis Rheum , vol.59 , pp. 222-226
    • Rouster-Stevens, K.A.1    Gursahaney, A.2    Ngai, K.L.3    Daru, J.A.4    Pachman, L.M.5
  • 8
    • 33646254122 scopus 로고    scopus 로고
    • Endothelial cell activation and neovascularization are prominent in dermatomyositis
    • Nagaraju K, Rider LG, Fan C, Chen YW, Mitsak M, Rawat R, et al. Endothelial cell activation and neovascularization are prominent in dermatomyositis. J Autoimmune Dis 2006; 3: 2.
    • (2006) J Autoimmune Dis , vol.3 , pp. 2
    • Nagaraju, K.1    Rider, L.G.2    Fan, C.3    Chen, Y.W.4    Mitsak, M.5    Rawat, R.6
  • 9
    • 33344455589 scopus 로고    scopus 로고
    • Duration of illness is an important variable for untreated children with juvenile dermatomyositis
    • Pachman LM, Abbott K, Sinacore JM, Amoruso L, Dyer A, Lipton R, et al. Duration of illness is an important variable for untreated children with juvenile dermatomyositis. J Pediatr 2006; 148: 247-53.
    • (2006) J Pediatr , vol.148 , pp. 247-253
    • Pachman, L.M.1    Abbott, K.2    Sinacore, J.M.3    Amoruso, L.4    Dyer, A.5    Lipton, R.6
  • 10
    • 33947108436 scopus 로고    scopus 로고
    • RANKL:osteoprotegerin ratio and bone mineral density in children with untreated juvenile dermatomyositis
    • Rouster-Stevens KA, Langman CB, Price HE, Seshadri R, Shore RM, Abbott K, et al. RANKL:osteoprotegerin ratio and bone mineral density in children with untreated juvenile dermatomyositis. Arthritis Rheum 2007; 56: 977-83.
    • (2007) Arthritis Rheum , vol.56 , pp. 977-983
    • Rouster-Stevens, K.A.1    Langman, C.B.2    Price, H.E.3    Seshadri, R.4    Shore, R.M.5    Abbott, K.6
  • 11
    • 70350523961 scopus 로고    scopus 로고
    • Interleukin-6 and type i interferon-regulated genes and chemokines mark disease activity in dermatomyositis
    • Bilgic H, Ytterberg SR, Amin S, McNallan KT, Wilson JC, Koeuth T, et al. Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis. Arthritis Rheum 2009; 60: 3436-46.
    • (2009) Arthritis Rheum , vol.60 , pp. 3436-3446
    • Bilgic, H.1    Ytterberg, S.R.2    Amin, S.3    McNallan, K.T.4    Wilson, J.C.5    Koeuth, T.6
  • 12
    • 0037090342 scopus 로고    scopus 로고
    • Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: A novel model of pathogenesis
    • Tezak Z, Hoffman EP, Lutz JL, Fedczyna TO, Stephan D, Bremer EG, et al. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol 2002; 168: 4154-63.
    • (2002) J Immunol , vol.168 , pp. 4154-4163
    • Tezak, Z.1    Hoffman, E.P.2    Lutz, J.L.3    Fedczyna, T.O.4    Stephan, D.5    Bremer, E.G.6
  • 13
    • 51349134921 scopus 로고    scopus 로고
    • Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis
    • Chen YW, Shi R, Geraci N, Shrestha S, Gordish-Dressman H, Pachman LM,. Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. BMC Immunol 2008; 9: 43.
    • (2008) BMC Immunol , vol.9 , pp. 43
    • Chen, Y.W.1    Shi, R.2    Geraci, N.3    Shrestha, S.4    Gordish-Dressman, H.5    Pachman, L.M.6
  • 14
    • 0024802552 scopus 로고
    • Early ultrastructural alterations in adult dermatomyositis: Capillary abnormalities precede other structural changes in muscle
    • De Visser M, Emslie-Smith AM, Engel AG,. Early ultrastructural alterations in adult dermatomyositis: capillary abnormalities precede other structural changes in muscle. J Neurol Sci 1989; 94: 181-92.
    • (1989) J Neurol Sci , vol.94 , pp. 181-192
    • De Visser, M.1    Emslie-Smith, A.M.2    Engel, A.G.3
  • 15
    • 0030027871 scopus 로고    scopus 로고
    • Leucocyte/endothelial cell adhesion receptors in muscle biopsies from patients with idiopathic inflammatory myopathies (IIM)
    • Cid MC, Grau JM, Casademont J, Tobias E, Picazo A, Coll-Vinent B, et al. Leucocyte/endothelial cell adhesion receptors in muscle biopsies from patients with idiopathic inflammatory myopathies (IIM). Clin Exp Immunol 1996; 104: 467-73.
    • (1996) Clin Exp Immunol , vol.104 , pp. 467-473
    • Cid, M.C.1    Grau, J.M.2    Casademont, J.3    Tobias, E.4    Picazo, A.5    Coll-Vinent, B.6
  • 16
    • 0344875464 scopus 로고    scopus 로고
    • Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies
    • Figarella-Branger D, Civatte M, Bartoli C, Pellissier JF,. Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies. Muscle Nerve 2003; 28: 659-82.
    • (2003) Muscle Nerve , vol.28 , pp. 659-682
    • Figarella-Branger, D.1    Civatte, M.2    Bartoli, C.3    Pellissier, J.F.4
  • 17
    • 65649133118 scopus 로고    scopus 로고
    • Increased expression of cell adhesion molecules in inflammatory myopathies: Diagnostic utility and pathogenetic insights
    • Jain A, Sharma MC, Sarkar C, Bhatia R, Singh S, Handa R,. Increased expression of cell adhesion molecules in inflammatory myopathies: diagnostic utility and pathogenetic insights. Folia Neuropathol 2009; 47: 33-42.
    • (2009) Folia Neuropathol , vol.47 , pp. 33-42
    • Jain, A.1    Sharma, M.C.2    Sarkar, C.3    Bhatia, R.4    Singh, S.5    Handa, R.6
  • 18
    • 1842478280 scopus 로고    scopus 로고
    • Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis
    • Sallum AM, Marie SK, Wakamatsu A, Sachetti S, Vianna MA, Silva CA, et al. Immunohistochemical analysis of adhesion molecule expression on muscle biopsy specimens from patients with juvenile dermatomyositis. J Rheumatol 2004; 31: 801-7.
    • (2004) J Rheumatol , vol.31 , pp. 801-807
    • Sallum, A.M.1    Marie, S.K.2    Wakamatsu, A.3    Sachetti, S.4    Vianna, M.A.5    Silva, C.A.6
  • 19
    • 31144445552 scopus 로고    scopus 로고
    • Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis
    • Sallum AM, Kiss MH, Silva CA, Wakamatsu A, Vianna MA, Sachetti S, et al. Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. Autoimmun Rev 2006; 5: 93-100.
    • (2006) Autoimmun Rev , vol.5 , pp. 93-100
    • Sallum, A.M.1    Kiss, M.H.2    Silva, C.A.3    Wakamatsu, A.4    Vianna, M.A.5    Sachetti, S.6
  • 20
    • 0029015389 scopus 로고
    • Expression of cell adhesion molecules in inflammatory myopathies
    • Tews DS, Goebel HH,. Expression of cell adhesion molecules in inflammatory myopathies. J Neuroimmunol 1995; 59: 185-94.
    • (1995) J Neuroimmunol , vol.59 , pp. 185-194
    • Tews, D.S.1    Goebel, H.H.2
  • 21
    • 0027210548 scopus 로고
    • Vascular cell adhesion molecule 1: Contrasting transcriptional control mechanisms in muscle and endothelium
    • Iademarco MF, McQuillan JJ, Dean DC,. Vascular cell adhesion molecule 1: contrasting transcriptional control mechanisms in muscle and endothelium. Proc Natl Acad Sci U S A 1993; 90: 3943-7.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3943-3947
    • Iademarco, M.F.1    McQuillan, J.J.2    Dean, D.C.3
  • 23
    • 0037413240 scopus 로고    scopus 로고
    • α4 integrins as therapeutic targets in autoimmune disease
    • Von Andrian UH, Engelhardt B,. α4 integrins as therapeutic targets in autoimmune disease. N Engl J Med 2003; 348: 68-72.
    • (2003) N Engl J Med , vol.348 , pp. 68-72
    • Von Andrian, U.H.1    Engelhardt, B.2
  • 24
    • 0029922156 scopus 로고    scopus 로고
    • Adhesion molecules in autoimmune disease
    • McMurray RW,. Adhesion molecules in autoimmune disease. Semin Arthritis Rheum 1996; 25: 215-33.
    • (1996) Semin Arthritis Rheum , vol.25 , pp. 215-233
    • McMurray, R.W.1
  • 25
    • 4243654218 scopus 로고    scopus 로고
    • Measurement of soluble adhesion molecules in biological fluids
    • Paul L.C. Issekutz T.B. editors. New York: Marcel Dekker;. p
    • Lebranchu Y, Valentin JF, Buchler M,. Measurement of soluble adhesion molecules in biological fluids. In:, Paul LC, Issekutz TB, editors. Adhesion molecules in health and disease. New York: Marcel Dekker; 1997. p. 87-122.
    • (1997) Adhesion Molecules in Health and Disease , pp. 87-122
    • Lebranchu, Y.1    Valentin, J.F.2    Buchler, M.3
  • 26
    • 0033623341 scopus 로고    scopus 로고
    • TNFα-308A allele in juvenile dermatomyositis: Association with increased production of tumor necrosis factor α, disease duration, and pathologic calcifications
    • Pachman LM, Liotta-Davis MR, Hong DK, Kinsella TR, Mendez EP, Kinder JM, et al. TNFα-308A allele in juvenile dermatomyositis: association with increased production of tumor necrosis factor α, disease duration, and pathologic calcifications. Arthritis Rheum 2000; 43: 2368-77.
    • (2000) Arthritis Rheum , vol.43 , pp. 2368-2377
    • Pachman, L.M.1    Liotta-Davis, M.R.2    Hong, D.K.3    Kinsella, T.R.4    Mendez, E.P.5    Kinder, J.M.6
  • 27
    • 0035010184 scopus 로고    scopus 로고
    • A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    • Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255-62.
    • (2001) J Clin Invest , vol.107 , pp. 1255-1262
    • Cybulsky, M.I.1    Iiyama, K.2    Li, H.3    Zhu, S.4    Chen, M.5    Iiyama, M.6
  • 28
    • 77957311397 scopus 로고    scopus 로고
    • The clinical potential of microRNAs
    • Budhu A, Ji J, Wang XW,. The clinical potential of microRNAs. J Hematol Oncol 2010; 3: 37.
    • (2010) J Hematol Oncol , vol.3 , pp. 37
    • Budhu, A.1    Ji, J.2    Wang, X.W.3
  • 29
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • Doench JG, Sharp PA,. Specificity of microRNA target selection in translational repression. Genes Dev 2004; 18: 504-11.
    • (2004) Genes Dev , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 30
    • 0030794169 scopus 로고    scopus 로고
    • A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis
    • Littler AJ, Buckley CD, Wordsworth P, Collins I, Martinson J, Simmons DL,. A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis. Br J Rheumatol 1997; 36: 164-9.
    • (1997) Br J Rheumatol , vol.36 , pp. 164-169
    • Littler, A.J.1    Buckley, C.D.2    Wordsworth, P.3    Collins, I.4    Martinson, J.5    Simmons, D.L.6
  • 31
    • 0027999047 scopus 로고
    • Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE): A long term prospective study
    • Spronk PE, Bootsma H, Huitema MG, Limburg PC, Kallenberg CG,. Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE): a long term prospective study. Clin Exp Immunol 1994; 97: 439-44.
    • (1994) Clin Exp Immunol , vol.97 , pp. 439-444
    • Spronk, P.E.1    Bootsma, H.2    Huitema, M.G.3    Limburg, P.C.4    Kallenberg, C.G.5
  • 32
    • 0033939885 scopus 로고    scopus 로고
    • Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma
    • Yamane K, Ihn H, Kubo M, Yazawa N, Kikuchi K, Soma Y, et al. Increased serum levels of soluble vascular cell adhesion molecule 1 and E-selectin in patients with localized scleroderma. J Am Acad Dermatol 2000; 42: 64-9.
    • (2000) J Am Acad Dermatol , vol.42 , pp. 64-69
    • Yamane, K.1    Ihn, H.2    Kubo, M.3    Yazawa, N.4    Kikuchi, K.5    Soma, Y.6
  • 33
    • 0036228893 scopus 로고    scopus 로고
    • Soluble adhesion molecules in pediatric rheumatic diseases
    • Bloom BJ, Miller LC, Blier PR,. Soluble adhesion molecules in pediatric rheumatic diseases. J Rheumatol 2002; 29: 832-6.
    • (2002) J Rheumatol , vol.29 , pp. 832-836
    • Bloom, B.J.1    Miller, L.C.2    Blier, P.R.3
  • 34
    • 0026777352 scopus 로고
    • Derivation of the SLEDAI: A disease activity index for lupus patients
    • the Committee on Prognosis Studies in SLE
    • Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang DH, and the Committee on Prognosis Studies in SLE. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 1992; 35: 630-40.
    • (1992) Arthritis Rheum , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.D.2    Urowitz, M.B.3    Caron, D.4    Chang, D.H.5
  • 35
    • 77958144092 scopus 로고    scopus 로고
    • The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: Potential role in atherogenesis and renal vascular rarefaction
    • Thacker SG, Berthier CC, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ,. The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. J Immunol 2010; 185: 4457-69.
    • (2010) J Immunol , vol.185 , pp. 4457-4469
    • Thacker, S.G.1    Berthier, C.C.2    Mattinzoli, D.3    Rastaldi, M.P.4    Kretzler, M.5    Kaplan, M.J.6
  • 36
    • 0027992589 scopus 로고
    • Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis: A biologic marker of disease activity with a possible role in the lack of acute-phase protein response
    • Gabay C, Gay-Croisier F, Roux-Lombard P, Meyer O, Maineti C, Guerne PA, et al. Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis: a biologic marker of disease activity with a possible role in the lack of acute-phase protein response. Arthritis Rheum 1994; 37: 1744-51.
    • (1994) Arthritis Rheum , vol.37 , pp. 1744-1751
    • Gabay, C.1    Gay-Croisier, F.2    Roux-Lombard, P.3    Meyer, O.4    Maineti, C.5    Guerne, P.A.6
  • 38
    • 79954618643 scopus 로고    scopus 로고
    • Molecular regulation of endothelial cell activation: Novel mechanisms and emerging targets
    • Charreau B,. Molecular regulation of endothelial cell activation: novel mechanisms and emerging targets. Curr Opin Organ Transplant 2011; 16: 207-13.
    • (2011) Curr Opin Organ Transplant , vol.16 , pp. 207-213
    • Charreau, B.1
  • 39
    • 52449100144 scopus 로고    scopus 로고
    • Role of microRNAs in vascular diseases, inflammation, and angiogenesis
    • Urbich C, Kuehbacher A, Dimmeler S,. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 2008; 79: 581-8.
    • (2008) Cardiovasc Res , vol.79 , pp. 581-588
    • Urbich, C.1    Kuehbacher, A.2    Dimmeler, S.3
  • 40
    • 79957630312 scopus 로고    scopus 로고
    • MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors
    • Bai Y, Bai X, Wang Z, Zhang X, Ruan C, Miao J,. MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors. Exp Mol Pathol 2011; 91: 471-7.
    • (2011) Exp Mol Pathol , vol.91 , pp. 471-477
    • Bai, Y.1    Bai, X.2    Wang, Z.3    Zhang, X.4    Ruan, C.5    Miao, J.6
  • 41
    • 79953048345 scopus 로고    scopus 로고
    • The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes
    • Ryu HS, Park SY, Ma D, Zhang J, Lee W,. The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One 2011; 6: e17343.
    • (2011) PLoS One , vol.6
    • Ryu, H.S.1    Park, S.Y.2    Ma, D.3    Zhang, J.4    Lee, W.5
  • 42
    • 40949124812 scopus 로고    scopus 로고
    • Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity
    • Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, et al. Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity. Medicine (Baltimore) 2008; 87: 70-86.
    • (2008) Medicine (Baltimore) , vol.87 , pp. 70-86
    • Bingham, A.1    Mamyrova, G.2    Rother, K.I.3    Oral, E.4    Cochran, E.5    Premkumar, A.6
  • 43
    • 80054752325 scopus 로고    scopus 로고
    • Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis
    • Eimer MJ, Brickman WJ, Seshadri R, Ramsey-Goldman R, McPherson DD, Smulevitz B, et al. Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis. J Pediatr 2011; 159: 795-801.
    • (2011) J Pediatr , vol.159 , pp. 795-801
    • Eimer, M.J.1    Brickman, W.J.2    Seshadri, R.3    Ramsey-Goldman, R.4    McPherson, D.D.5    Smulevitz, B.6


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