Sequential low-dose step-up and step-down protocols with recombinant follicle-stimulating hormone in polycystic ovary syndrome: Prospective comparison with step-down protocol

Archives of Gynecology and Obstetrics

Volumn 286, Issue 5, 2012, Pages 1291-1297

  Casadei, Luisa ^a,b   Puca, Francesco ^a,b   Emidi, Emanuela ^a,b   Manicuti, Claudia ^a,b   Madrigale, Alessandra ^a,b   Piccione, Emilio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

Low dose step up protocol; Ovarian stimulation; Polycystic ovary syndrome; Recombinant FSH; Step down protocol

Indexed keywords

PROGESTERONE; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLICULAR PHASE; HUMAN; INFERTILITY; LOADING DRUG DOSE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; OVARY DEVELOPMENT; OVARY FOLLICLE; OVARY POLYCYSTIC DISEASE; PROSPECTIVE STUDY; SEQUENTIAL ANALYSIS; TREATMENT RESPONSE;

ADULT; FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; INFERTILITY, FEMALE; OVARIAN FOLLICLE; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; YOUNG ADULT;

EID: 84868102235     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2430-3     Document Type: Article

References (23)

1. Broekmans FJ, Fauser BC (2006) Diagnostic criteria for polycystic ovarian syndrome. Endocrine 30:3-11
2. Fiedler K, Ezcurra D (2012) Predicting and preventing ovarian hyperstimulation syndrome (OHSS): the need for individualized not standardized treatment. Reprod Biol Endocrinol. 10:32 [Epub ahead of print]
3. Thompson CR, Hansen LM (1970) Pergonal (menotropins):a summary of clinical experience in the induction of ovulation and pregnancy. Fertil Steril 21:844-853
4. Wang CF, Gemzell C (1980) The use of human gonadotrophins for induction of ovulation in women with polycystic ovarian disease. Fertil Steril 33:479-486
5. Hamilton-Fairley D, Kiddy D, Watson H, Sagle M, Franks S (1991) Low-dose gonadotrophin therapy for induction of ovulation in 100 women with polycystic ovarian syndrome. Hum Reprod 6:1095-1099
6. Shoham Z, Patel A, Jacobs HS (1991) Polycystic ovary syndrome: safety and effectiveness of stepwise and low-dose administration of purified follicle stimulating hormone. Fertil Steril 55:1051-1056
7. White D, Polson DW, Kiddy D, Sagle P, Watson H, Gilling-Smith C, Hamilton-Fairley D, Franks S (1996) Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J Clin Endocrinol Metab 81:3821-3824
8. van Santbrink EJ, Fauser BC (1997) Urinary follicle-stimulating hormone for normogonadotropic clomiphene-resistant anovulatory infertility: prospective, randomized comparison between low dose step-up and step-down dose regimens. J Clin Endocrinol Metab 82:3597-3602
9. Mizunuma H, Takagi T, Yamada K, Andoh K, Ibuki Y, Igarashi M (1991) Ovulation induction by step-down administration of purified urinary follicle-stimulation hormone in patients with polycystic ovarian syndrome. Fertil Steril 55:1195-1196
10. van Santbrink EJ, Donderwinkel PF, van Dessel TJHM, Fauser BC (1995) Gonadotrophin induction of ovulation using a step-down dose regimen: single centre clinical experience in 82 patients. Hum Reprod 10:1048-1053
11. Andoh K, Mizunuma H, Liu X, Kamijo T, Yamada K, Ibuki Y (1998) A comparative study of fixed-dose, step-down, and low-dose step-up regimens of human menopausal gonadotropin for patients with polycystic ovary syndrome. Fertil Steril 70:840-846
12. Balasch J, Fabregues F, Crues M, Puerto B, Peñarrubia J, Vanrell JA (2001) Follicular development and hormone concentrations following recombinant FSH administration for anovulation associated with polycystic ovarian syndrome: prospective, randomized comparison between low-dose step-up and modified step-down regimens. Hum Reprod 16:652-656
13. Christin-Maitre S, Hugues JN, on behalf of the Recombinant FSH Study Group (2003) A comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndrome. Hum Reprod 18:1626-1631
14. Hugues JN, Cédrin-Durnerin I, Avril C, Bulwa S, Hervé F, Uzan M (1996) Sequenzial step-up and step-down dose regimen: an alternative method for ovulation induction with follicle-stimulating hormone in polycystic ovarian syndrome. Hum Reprod 11:2581-2584
15. Hedon B, Hugues JN, Emperaire JC, Chabaud JJ, Barbereau D, Boujenah A, Howles CM, Truong F (1998) A comparative prospective study of a chronic low dose versus a conventional ovulation stimulation regimen using recombinant human follicle stimulating hormone in anovulatory infertile women. Hum Reprod 13:2688-2692
16. Leader A for the Monofollicular Ovulation Induction Study Group (2006) Improved monofollicular ovulation in anovulatory or oligo-ovulatory women after a low-dose step-up protocol with weekly increments of 25 international units of follicle-stimulating hormone. Fertil Steril 85:1766-1773
17. Orvieto R, Homburg R (2009) Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy. Fertil Steril 91:1533-1535
18. Hugues JN, Cédrin-Durnerin I, Howles CM, On Behalf of the Recombinant FSH OI Study Group (2006) The use of a decremental dose regimen in patients treated with a chronic low-dose step-up protocol for WHO Group II anovulation: a prospective randomized multicentre study. Hum Reprod 11:2817-2822
19. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrom e. Fertil Steril 81:19-25
20. Brown JB (1978) Pituitary control of ovarian function. Concept derived from gonadotropin therapy. Aust NZ J Obstet Gynaecol 18:47-54
21. Ben Rafael Z, Levy T, Schoemaker J (1995) Pharmacokinetics of follicle-stimulating hormone: clinical significance. Fertil Steril 63:689-700
22. Balasch J, Fabregues F, Crues M, Casamitjana R, Puerto B, Vanrell JA (2000) Recombinant human follicle-stimulating hormone for ovulation induction in polycystic ovary syndrome: a prospective, randomized trial of two starting doses in a chronic low-dose step-up protocol. J Assist Reprod Genet 17:561-565
23. Casadei L, Zamaro V, Calcagni M, Ticconi C, Dorrucci M, Piccione E (2006) Homologous intrauterine insemination in controlled ovarian hyperstimulation cycles: a comparison among three different regimens. Eur J Obstet Gynecol Reprod Biol 129:155-161