Sequential step-up and step-down dose regimen: An alternative method for ovulation induction with follicle-stimulating hormone in polycystic ovarian syndrome

Human Reproduction

Volumn 11, Issue 12, 1996, Pages 2581-2584

  Hugues, Jean Noël ^a   Cédrin Durnerin, Isabelle ^a   Avril, Catherine ^b   Bulwa, Sylvie ^a   Hervé, Florence ^a   Uzan, Michèle ^a  

^a HÔPITAL JEAN VERDIER   (France)

^b Clinique Saint Antoine   (France)

Author keywords

Gonadotrophin therapy; Ovarian hyperstimulation syndrome; Polycystic ovarian syndrome; Spontaneous abortion rate

Indexed keywords

ANDROSTENEDIONE; CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; ESTRADIOL; FOLLITROPIN; GONADOTROPHIN ENDO; LUTEINIZING HORMONE; PROGESTERONE; PROLACTIN; TESTOSTERONE; UNCLASSIFIED DRUG; UROFOLLITROPIN;

ADULT; ANDROSTENEDIONE BLOOD LEVEL; ANOVULATION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG THERAPY; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; OVARY DISEASE; OVARY FOLLICLE DEVELOPMENT; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; PROLACTIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL;

EID: 0030482132     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.humrep.a019173     Document Type: Article

References (24)

1. Adams, J., Franks, S., Polson, D.W. et al. (1985) Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet, ii, 1375-1378.
2. Ben-Rafael, Z., Strauss, J.F., III, Mastroianni, L. et al. (1986) Differences in ovarian stimulation in human menopausal gonadotrophin treated woman may be related to follicle-stimulating hormone accumulation. Fertil. Steril., 46, 586-592.
3. Benadiva, C.A., Ben-Rafael, Z., Strauss, J.F., III et al. (1988) Ovarian response of individuals to different doses of human menopausal gonadotrophin. Fertil. Steril., 49, 997-1001.
4. Brown, J.B. (1978) Pituitary control of ovarian function - concepts derived from gonadotrophin therapy. Aust. N.Z J. Obstet. Gynaecol, 18, 47-54.
5. Brzyski, R.G., Grow. D.R., Sims, J.A. et al (1995) Increase in androgen:estrogen ratio specifically during low-dose follicle-stimulating hormone therapy for polycystic ovary syndrome. Fertil. Steril., 64, 693-697.
6. Buvat, J.B., Buvat-Herbaut, M., Marcolin, G. et al. (1989) Purified folliclestimulating hormone in polycystic ovary syndrome: slow administration is safer and more effective. Fertil. Steril., 52, 553-559.
7. Dale, O., Tanbo, T., Lunde, O. et al. (1993) Ovulation induction with low dose follicle stimulating hormone in women with the polycystic ovary syndrome. Acta Obstet. Gynecol. Scand., 72, 43-46.
8. Hamilton-Fairley, D., Kiddy, D., Watson, H. et al. (1991) Low-dose gonadotrophin therapy for induction of ovulation in 100 women with polycystic ovary syndrome. Hum. Reprod., 6, 1095-1099.
9. Hillier, S.G., Yong, E.L., Illingworth, P.J. et al. (1991) Effect of recombinant inhibin on androgen synthesis in cultured human thecal cells. Mol. Cell. Endocrinol., 75, R1-6.
10. Homburg, R., Levy, T. and Ben-Rafael, Z. (1995) A comparative prospective study of conventional regimen with chronic low-dose administration of follicle-stimulating hormone for anovulation associated with polycystic ovary syndrome. Fertil. Steril., 63, 729-733.
11. Lolis, D.E., Tsolas, O. and Messinis, I.E. (1995) The follicle-stimulating hormone threshold level for follicle maturation in superovulated cycles. Fertil. Steril., 63, 1272-1277.
12. Pache, T.D., Wladimiroff, J.W., de Jong, F.H. et al. (1990) Growth patterns of nondominant ovarian follicles during the normal menstrual cycle. Fertil. Steril., 54, 638-644.
13. Polson, D.W., Mason, H.D., Saldahna, M.B. et al. (1987) Ovulation of a single dominant follicle during treatment with low dose pulsatile follicle stimulating hormone in women with polycystic ovary syndrome. Clin. Endocrinol., 26, 205-212.
14. Porchet, H.C., Le Cotonnec, J.Y. and Loumaye. E. (1994) Clinical pharmacology of recombinant human follicle-stimulating hormone. III. Pharmacokinetic-pharmacodynamic modeling after repeated subcutaneous administration. Fertil. Steril., 61, 687-695.
15. Rabinovici, J., Kushnir, O., Shalev, J. et al. (1987) Rescue of menotropin cycles prone to develop ovarian hyperstimulation. Br. J. Obstet. Gynaecol., 94, 1098-1102.
16. Schoot, D.C., Pache, T.D., Hop, W.C. et al. (1992) Growth patterns of ovarian follicles during induction of ovulation with decreasing doses of human menopausal gonadotrophin following presumed selection in polycystic ovary syndrome. Fertil. Steril., 57, 1117-1120.
17. Seibel, M.M., Kamrava, M.M., McArdle, C. et al. (1984) Treatment of polycystic ovarian disease with chronic low dose follicle stimulating hormone: biochemical changes and ultrasound correlation. Int. J. Fertil., 29, 39-43.
18. Shoham, Z., Patel, A. and Jacobs, H.S. (1991) Polycystic ovarian syndrome: safety and effectiveness of stepwise and low dose administration of purified follicle stimulating hormone. Fertil. Steril., 55, 1051-1056.
19. Templeton, A.A., Messinis, I.E. and Baird, D.T. (1986) The characteristics of ovarian follicles in spontaneous and stimulated cycles in which there was an endogenous LH surge. Fertil. Steril., 46, 1113-1117.
20. Van der Meer, M., Hompes, P.G.A., Scheele, F. et al. (1994) Follicle stimulating hormone (FSH) dynamics of low dose step-up ovulation induction with FSH in patients with polycystic ovary syndrome. Hum. Reprod., 9, 1612-1617.
21. Van Santbrink, E.J.P., Hop, W.C., Van Dessel, T.J.H.M. et al (1995) Dcremental follicle-stimulating hormone and dominant follicle development during the normal menstrual cycle. Fertil. Steril., 64, 37-43.
22. Wang, C.F. and Gemzell, C. (1980) The use of human gonadotrophin for the induction of ovulation in women with polycystic ovarian disease. Fertil. Steril., 33, 479-486.
23. World Health Organization Scientific Group Report (1973) Agents Stimulating Gonadal Function in the Human. World Health Organization, Technical Report Series.
24. Zeleznik, A.J. and Kubik, C.J. (1986) Ovarian responses in macaques to pulsatile infusion of follicle-stimulating hormone (FSH) and luteinizing hormone: increased sensitivity of the maturing follicle to FSH. Endocrinology, 119, 2025-2032.