Risk Factors Associated with Death in In-Hospital Pediatric Convulsive Status Epilepticus

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Loddenkemper, Tobias ^a   Syed, Tanvir U ^b   Ramgopal, Sriram ^a   Gulati, Deepak ^b   Thanaviratananich, Sikawat ^b   Kothare, Sanjeev V ^a   Alshekhlee, Amer ^c   Koubeissi, Mohamad Z ^b,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION; BRAIN DAMAGE; BRAIN DISEASE; BRAIN STEM TUMOR; CEREBRAL PALSY; CHILD; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA BASE; DROWNING; ENCEPHALITIS; EPILEPTIC STATE; ETHNICITY; FEMALE; HEART ARREST; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYDROCEPHALUS; HYPERTENSION; HYPOGLYCEMIA; INFANT; INFANTILE SPASM; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PATIENT MONITORING; PEDIATRIC HOSPITAL; PNEUMONIA; PRESCHOOL CHILD; RACE DIFFERENCE; RESPIRATORY FAILURE; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SEPSIS; SUBDURAL HEMATOMA; VIRUS ENCEPHALITIS;

CHILD; CHILD, PRESCHOOL; CONFIDENCE INTERVALS; FEMALE; HOSPITALIZATION; HUMANS; HYPOGLYCEMIA; INFANT; INPATIENTS; MALE; ODDS RATIO; RESPIRATION, ARTIFICIAL; RISK FACTORS; SEPSIS; SHOCK, HEMORRHAGIC; STATUS EPILEPTICUS;

EID: 84868101510     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047474     Document Type: Article

References (56)

1. Working Group on Status Epilepticus (1993) Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA 270: 854-859.
2. Sillanpaa M, Shinnar S, (2002) Status epilepticus in a population-based cohort with childhood-onset epilepsy in Finland. Ann Neurol 52: 303-310.
3. Wu YW, Shek DW, Garcia PA, Zhao S, Johnston SC, (2002) Incidence and mortality of generalized convulsive status epilepticus in California. Neurology 58: 1070-1076.
4. Sahin M, Menache CC, Holmes GL, Riviello JJ, (2001) Outcome of severe refractory status epilepticus in children. Epilepsia 42: 1461-1467.
5. Koubeissi M, Alshekhlee A, (2007) In-hospital mortality of generalized convulsive status epilepticus: a large US sample. Neurology 69: 886-893.
6. Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA, (1997) Short-term mortality after a first episode of status epilepticus. Epilepsia 38: 1344-1349.
7. Agency for Healthcare Research and Quality (2011) Overview of the Kids' Inpatient Database (KID). Available: http://www.hcup-us.ahrq.gov/kidoverview.jsp. Accessed 2011 Dec 20.
8. Gulati S, Kalra V, Sridhar MR, (2005) Status epilepticus in Indian children in a tertiary care center. Indian J Pediatr 72: 105-108.
9. Berg AT, Shinnar S, Levy SR, Testa FM, Smith-Rapaport S, et al. (2001) Early development of intractable epilepsy in children: a prospective study. Neurology 56: 1445-1452.
10. Mah JK, Mah MW, (1999) Pediatric status epilepticus: a perspective from Saudi Arabia. Pediatr Neurol 20: 364-369.
11. Ozdemir D, Gulez P, Uran N, Yendur G, Kavakli T, et al. (2005) Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus. Seizure 14: 129-132.
12. Aicardi J, Chevrie JJ, (1970) Convulsive status epilepticus in infants and children. A study of 239 cases. Epilepsia 11: 187-197.
13. Dunn DW, (1988) Status epilepticus in children: etiology, clinical features, and outcome. J Child Neurol 3: 167-173.
14. DeLorenzo RJ, Towne AR, Pellock JM, Ko D, (1992) Status epilepticus in children, adults, and the elderly. Epilepsia 33 Suppl 4: S15-25.
15. Banerjee PN, Hauser WA (2007) Incidence and Prevalence. In: Engel J, Pedley TA, Aicardi J, Dichter MA, Moshé S et al., editors. Epilepsy: A Comprehensive Textbook: Lippincott Williams & Wilkins. pp. 45-56.
16. DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, et al. (1996) A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 46: 1029-1035.
17. Knake S, Rosenow F, Vescovi M, Oertel WH, Mueller HH, et al. (2001) Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 42: 714-718.
18. Logroscino G, Hesdorffer DC, Cascino G, Hauser WA, Coeytaux A, et al. (2005) Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia 46 Suppl 11: 46-48.
19. Chevrie JJ, Aicardi J, (1979) Convulsive disorders in the first year of life: persistence of epileptic seizures. Epilepsia 20: 643-649.
20. Sharip A, Sorvillo F, Redelings MD, Mascola L, Wise M, et al. (2006) Population-based analysis of meningococcal disease mortality in the United States: 1990-2002. Pediatr Infect Dis J 25: 191-194.
21. Day JF, Shaman J, (2009) Severe winter freezes enhance St. Louis encephalitis virus amplification and epidemic transmission in peninsular Florida. J Med Entomol 46: 1498-1506.
22. Barnard C, Wirrell E, (1999) Does status epilepticus in children cause developmental deterioration and exacerbation of epilepsy? J Child Neurol 14: 787-794.
23. Kang DC, Lee YM, Lee J, Kim HD, Coe C, (2005) Prognostic factors of status epilepticus in children. Yonsei Med J 46: 27-33.
24. Callenbach PM, Westendorp RG, Geerts AT, Arts WF, Peeters EA, et al. (2001) Mortality risk in children with epilepsy: the Dutch study of epilepsy in childhood. Pediatrics 107: 1259-1263.
25. Brevoord JC, Joosten KF, Arts WF, van Rooij RW, de Hoog M, (2005) Status epilepticus: clinical analysis of a treatment protocol based on midazolam and phenytoin. J Child Neurol 20: 476-481.
26. Chin RF, Verhulst L, Neville BG, Peters MJ, Scott RC, (2004) Inappropriate emergency management of status epilepticus in children contributes to need for intensive care. J Neurol Neurosurg Psychiatry 75: 1584-1588.
27. Molinero MR, Holden KR, Rodriguez LC, Collins JS, Samra JA, et al. (2009) Pediatric convulsive status epilepticus in Honduras, Central America. Epilepsia 50: 2314-2319.
28. Kramer U, Shorer Z, Ben-Zeev B, Lerman-Sagie T, Goldberg-Stern H, et al. (2005) Severe refractory status epilepticus owing to presumed encephalitis. J Child Neurol 20: 184-187.
29. Sadarangani M, Seaton C, Scott JA, Ogutu B, Edwards T, et al. (2008) Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study. Lancet Neurol 7: 145-150.
30. Berg AT, Shinnar S, Testa FM, Levy SR, Frobish D, et al. (2004) Status epilepticus after the initial diagnosis of epilepsy in children. Neurology 63: 1027-1034.
31. Ryan CA, Dowling G, (1993) Drowning deaths in people with epilepsy. CMAJ 148: 781-784.
32. Wilson FC, Harpur J, Watson T, Morrow JI, (2003) Adult survivors of severe cerebral hypoxia-case series survey and comparative analysis. NeuroRehabilitation 18: 291-298.
33. Morrison G, Gibbons E, Whitehouse WP, (2006) High-dose midazolam therapy for refractory status epilepticus in children. Intensive Care Med 32: 2070-2076.
34. Waterhouse EJ, Garnett LK, Towne AR, Morton LD, Barnes T, et al. (1999) Prospective population-based study of intermittent and continuous convulsive status epilepticus in Richmond, Virginia. Epilepsia 40: 752-758.
35. Konrad F, Schreiber T, Brecht-Kraus D, Georgieff M, (1994) Mucociliary transport in ICU patients. Chest 105: 237-241.
36. Li JM, Chen L, Zhou B, Zhu Y, Zhou D, (2009) Convulsive status epilepticus in adults and adolescents of southwest China: mortality, etiology, and predictors of death. Epilepsy Behav 14: 146-149.
37. Prasad K, Krishnan PR, Al-Roomi K, Sequeira R, (2007) Anticonvulsant therapy for status epilepticus. Br J Clin Pharmacol 63: 640-647.
38. Lowenstein DH, Bleck T, Macdonald RL, (1999) It's time to revise the definition of status epilepticus. Epilepsia 40: 120-122.
39. Logroscino G, Hesdorffer DC, Cascino GD, Annegers JF, Bagiella E, et al. (2002) Long-term mortality after a first episode of status epilepticus. Neurology 58: 537-541.
40. de Pont AC, de Jager CP, van den Bergh WM, Schultz MJ, (2011) Recovery from near drowning and postanoxic status epilepticus with controlled hypothermia. Neth J Med 69: 196-197.
41. Maytal J, Shinnar S, Moshe SL, Alvarez LA, (1989) Low morbidity and mortality of status epilepticus in children. Pediatrics 83: 323-331.
42. Scholtes FB, Renier WO, Meinardi H, (1996) Status epilepticus in children. Seizure 5: 177-184.
43. Kim SJ, Lee DY, Kim JS, (2001) Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. Pediatr Neurol 25: 217-220.
44. Tabarki B, Yacoub M, Selmi H, Oubich F, Barsaoui S, et al. (2001) Infantile status epilepticus in Tunisia. Clinical, etiological and prognostic aspects. Seizure 10: 365-369.
45. Ogutu BR, Newton CR, Crawley J, Muchohi SN, Otieno GO, et al. (2002) Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions. Br J Clin Pharmacol 53: 49-57.
46. Singhi S, Murthy A, Singhi P, Jayashree M, (2002) Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. J Child Neurol 17: 106-110.
47. KarasalIhoGlu S, Oner N, CeLtik C, Celik Y, Biner B, et al. (2003) Risk factors of status epilepticus in children. Pediatr Int 45: 429-434.
48. Asadi-Pooya AA, Poordast A, (2005) Etiologies and outcomes of status epilepticus in children. Epilepsy Behav 7: 502-505.
49. Maegaki Y, Kurozawa Y, Hanaki K, Ohno K, (2005) Risk factors for fatality and neurological sequelae after status epilepticus in children. Neuropediatrics 36: 186-192.
50. Ahmad S, Ellis JC, Kamwendo H, Molyneux E, (2006) Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. Lancet 367: 1591-1597.
51. Chen L, Zhou B, Li JM, Zhu Y, Wang JH, et al. (2009) Clinical features of convulsive status epilepticus: a study of 220 cases in western China. Eur J Neurol 16: 444-449.
52. Hayashi K, Osawa M, Aihara M, Izumi T, Ohtsuka Y, et al. (2007) Efficacy of intravenous midazolam for status epilepticus in childhood. Pediatr Neurol 36: 366-372.
53. Muchohi SN, Obiero K, Newton CR, Ogutu BR, Edwards G, et al. (2008) Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. Br J Clin Pharmacol 65: 12-21.
54. Mpimbaza A, Ndeezi G, Staedke S, Rosenthal PJ, Byarugaba J, (2008) Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics 121: e58-64.
55. Siddiqui TS, Anis ur R, Jan MA, Wazeer MS, Burki MK, (2008) Status epilepticus: aetiology and outcome in children. J Ayub Med Coll Abbottabad 20: 51-53.
56. Lin KL, Lin JJ, Hsia SH, Wu CT, Wang HS, (2009) Analysis of convulsive status epilepticus in children of Taiwan. Pediatr Neurol 41: 413-418.