Growth-differentiation factor 15 predicts worsening of albuminuria in patients with type 2 diabetes

Diabetes Care

Volumn 35, Issue 11, 2012, Pages 2340-2346

  Hellemons, Merel E ^a   Mazagova, Magdalena ^a   Gansevoort, Ron T ^a   Henning, Robert H ^a   De Zeeuw, Dick ^a   Bakker, Stephan J L ^a   Lambers Heerspink, Hiddo J ^a   Deelman, Leo E ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 15;

ADULT; AGED; ALBUMINURIA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE EXACERBATION; DISEASE MARKER; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTIVE VALUE; SENSITIVITY ANALYSIS;

AGED; ALBUMINURIA; DIABETES MELLITUS, TYPE 2; FEMALE; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; HYPERTENSION; MALE; MIDDLE AGED;

EID: 84868100661     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0180     Document Type: Article

References (27)

1. Collins AJ, Foley RN, Herzog C, Chavers B, Gilbertson D, Ishani A, et al. US Renal Data System 2010 Annual Data Report (Abstract). Am J Kidney Dis 2011;57(1 Suppl. 1):A8
2. Stewart JH, McCredie MR, Williams SM; ESRD Incidence Study Group. Divergent trends in the incidence of end-stage renal disease due to Type 1 and Type 2 diabetes in Europe, Canada and Australia during 1998-2002. Diabet Med 2006;23:1364-1369 (Pubitemid 44787802)
3. Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR; UKPDS GROUP. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int 2003;63:225-232 (Pubitemid 35463925)
4. de Zeeuw D, Lambers Heerspink HJ, Gansevoort RT, Bakker SJL. How to improve renal outcome in diabetes and hypertension - the importance of early screening for and treatment of microalbuminuria. Eur Nephr 2009;3:13-15
5. Parving HH, Lehnert H, Bröchner-Mortensen J, Gomis R, Andersen S, Arner P; Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001;345:870-878
6. Ruggenenti P, Fassi A, Ilieva AP, et al.; Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) Investigators. Preventing microalbuminuria in type 2 diabetes. N Engl J Med 2004;351:1941-1951 (Pubitemid 39447135)
7. Forsblom CM, Groop PH, Ekstrand A, et al. Predictors of progression from normoalbuminuria to microalbuminuria in NIDDM. Diabetes Care 1998;21:1932-1938 (Pubitemid 28478296)
8. Hellemons ME, Kerschbaum J, Bakker SJL, et al. Validity of biomarkers predicting onset or progression of nephropathy in patients with type 2 diabetes: A systematic review. Diabet Med 2012;29:567-577
9. Pinto-Sietsma SJ, Janssen WM, Hillege HL, Navis G, De Zeeuw D, De Jong PE. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol 2000;11:1882-1888
10. Kempf T, Björklund E, Olofsson S, et al. Growth-differentiation factor-15 improves risk strati fication in ST-segment elevation myocardial infarction. Eur Heart J 2007;28:2858-2865 (Pubitemid 350233034)
11. Khan SQ, Ng K, Dhillon O, et al. Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction. Eur Heart J 2009;30:1057-1065
12. Wollert KC, Kempf T, Lagerqvist B, et al. Growth differentiation factor 15 for risk strati fication and selection of an invasive treatment strategy in non ST-elevation acute coronary syndrome. Circulation 2007;116:1540-1548 (Pubitemid 47511417)
13. Lajer M, Jorsal A, Tarnow L, Parving HH, Rossing P. Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy. Diabetes Care 2010;33:1567-1572
14. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D; Modification of Diet in Renal Disease Study Group. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 1999;130:461-470 (Pubitemid 29135798)
15. Pencina MJ, D'Agostino RB, Vasan RS. Statistical methods for assessment of added usefulness of newbiomarkers. Clin Chem Lab Med 2010;48:1703-1711
16. Pencina MJ, D'Agostino RBS Sr, D'Agostino RB Jr, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008;27:157-172; discussion 207-212
17. Pepe MS, Janes H, Longton G, Leisenring W, Newcomb P. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J Epidemiol 2004;159:882-890 (Pubitemid 38657490)
18. Heger J, Schiegnitz E, von Waldthausen D, Anwar MM, Piper HM, Euler G. Growth differentiation factor 15 acts anti-apoptotic and pro-hypertrophic in adult cardiomyocytes. J Cell Physiol 2010;224:120-126
19. Schlittenhardt D, Schober A, Strelau J, et al. Involvement of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in oxLDL-induced apoptosis of human macrophages in vitro and in arteriosclerotic lesions. Cell Tissue Res 2004;318:325-333 (Pubitemid 39506502)
20. Xu J, Kimball TR, Lorenz JN, et al. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res 2006;98:342-350
21. Kempf T, Zarbock A, Widera C, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med 2011;17:581-588
22. Deckert T, Feldt-Rasmussen B, Borch-Johnsen K, Jensen T, Kofoed-Enevoldsen A. Albuminuria re flects widespread vascular damage. The Steno hypothesis. Diabetologia 1989;32:219-226 (Pubitemid 19136363)
23. Wiklund FE, Bennet AM, Magnusson PK, et al. Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality. Aging Cell 2010;9:1057-1064
24. Ravid M, Brosh D, Ravid-Safran D, Levy Z, Rachmani R. Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch Intern Med 1998;158:998-1004 (Pubitemid 28213577)
25. Viazzi F, Leoncini G, Conti N, et al. Microalbuminuria is a predictor of chronic renal insufficiency in patients without diabetes and with hypertension: the MAGIC study. Clin J Am Soc Nephrol 2010;5:1099-1106
26. Viazzi F, Leoncini G, Conti N, et al. Combined effect of albuminuria and estimated glomerular filtration rate on cardiovascular events and all-cause mortality in uncomplicated hypertensive patients. J Hypertens 2010;28:848-855
27. Copas JB, Corbett P. Overestimation of the receiver operating characteristic curve for logistic regression. Biometrika 2002;89:315-333