Enzymatic pathway for biodegrading microcystin LR in Sphingopyxis sp. C-1

Journal of Bioscience and Bioengineering

Volumn 114, Issue 6, 2012, Pages 630-634

  Shimizu, Kazuya ^a   Maseda, Hideaki ^b   Okano, Kunihiro ^c   Kurashima, Takumi ^d   Kawauchi, Yukio ^e   Xue, Qiang ^d   Utsumi, Motoo ^d   Zhang, Zhenya ^d   Sugiura, Norio ^d  

^a TOYO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c AKITA PREFECTURAL UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e Mitsubishi Chemical Analytech Co Ltd   (Japan)

Author keywords

Microcystin; Microcystin biodegradation pathway; Microcystin degrading bacterium; Mlr gene cluster; MlrB; MlrC

Indexed keywords

BIODEGRADATION PATHWAYS; GENE CLUSTERS; MICROCYSTINS; MLRB; MLRC;

AMINO ACIDS; BIODEGRADATION; ESCHERICHIA COLI; GENES; LINEARIZATION;

TOXIC MATERIALS;

MICROCYSTIN LR; MICROCYSTIN LR B; MICROCYSTIN LR C; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; CYANOBACTERIUM; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPHINGOPYXIS;

BACTERIAL PROTEINS; BACTERIAL TOXINS; BIODEGRADATION, ENVIRONMENTAL; ESCHERICHIA COLI; GENES, BACTERIAL; MARINE TOXINS; MICROCYSTINS; MULTIGENE FAMILY; PROTEOLYSIS; SPHINGOMONADACEAE;

BACTERIA (MICROORGANISMS); CYANOBACTERIA; ESCHERICHIA COLI; SPHINGOPYXIS SP. C-1;

EID: 84868096045     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.07.004     Document Type: Article

References (23)

1. Pearson L., Mihali T., Moffitt M., Kellmann R., Neilan B. On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. Mar. Drugs 2010, 8:1650-1680.
2. Paerl H.W., Huisman J. Climate. blooms like it hot. Science 2008, 320:57-58.
3. Imanishi S., Harada K. Proteomics approach on microcystin binding proteins in mouse liver for investigation of microcystin toxicity. Toxicon 2004, 43:651-659.
4. Jochimsen E.M., Carmichael W.W., An J.S., Cardo D.M., Cookson S.T., Holmes C.E., Antunes M.B., de Melo Fiho D.A., Lyra T.M., Barreto V.S., Azevedo S.M., Jarvis W.R. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N. Engl. J. Med. 1998, 338:873-878.
5. Ross C., Santiago-Vazquez L., Paul V. Toxin release in response to oxidative stress and programmed cell death in the cyanobacterium Microcystis aeruginosa. Aquat. Toxicol. 2006, 78:66-73.
6. Ibelings B.W., Chorus I. Accumulation of cyanobacterial toxins in freshwater " seafood" and its consequences for public health: a review. Environ. Pollut. 2007, 150:177-192.
7. Ozawa K., Yokoyama A., Ishikawa K., Kumagai M., Watanabe M.F., Park H.-D. Accumulation and depuration of microcystin produced by the cyanobacterium Microcystis in a freshwater snail. Limnology 2003, 4:131-138.
8. Bourne D.G., Jones G.J., Blakeley R.L., Jones A., Negri A.P., Riddles P. Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR. Appl. Environ. Microbiol. 1996, 62:4086-4094.
9. Bourne D.G., Riddles P., Jones G.J., Smith W., Blakeley R.L. Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR. Environ. Toxicol. 2001, 16:523-534.
10. Harada K., Imanishi S., Kato H., Mizuno M., Ito E., Tsuji K. Isolation of Adda from microcystin-LR by microbial degradation. Toxicon 2004, 44:107-109.
11. Imanishi S., Kato H., Mizuno M., Tsuji K., Harada K. Bacterial degradation of microcystins and nodularin. Chem. Res. Toxicol. 2005, 18:591-598.
12. Jiang Y., Shao J., Wu X., Xu Y., Li R. Active and silent members in the mlr gene cluster of a microcystin-degrading bacterium isolated from Lake Taihu, China. FEMS Microbiol. Lett. 2011, 322:108-114.
13. Shimizu K., Maseda H., Okano K., Itayama T., Kawauchi Y., Chen R., Utsumi M., Zhang Z., Sugiura N. How microcystin-degrading bacteria express microcystin degradation activity. Lakes Reservoirs: Res. Manag. 2011, 16:169-178.
14. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual 1989, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 2nd ed.
15. Maseda H., Kitao M., Eda S., Yoshihara E., Nakae T. A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa. Mol. Microbiol. 2002, 46:677-686.
16. Okano K., Shimizu K., Kawauchi Y., Maseda H., Utsumi M., Zhang Z., Neilan B.A., Sugiura N. Characteristics of a microcystin-degrading bacterium under alkaline environmental conditions. J. Toxicol. 2009, 2009:1-9.
17. Maynes J.T., Luu H.A., Cherney M.M., Andersen R.J., Williams D., Holmes C.F.B., James M.N.G. Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. J. Mol. Biol. 2006, 356:111-120.
18. Dziga D., Wladyka B., Zieliñska G., Meriluoto J. Heterologous expression and characterization of microcystinase. Toxicon 2012, 59:578-586.
19. Yan H., Wang J., Chen J., Wei W., Wang H., Wang H. Characterization of the first step involved in enzymatic pathway for microcystin-RR biodegraded by Sphingopyxis sp. USTB-05. Chemosphere 2012, 87:12-18.
20. Maruyama T., Kato K., Yokoyama A., Tanaka T., Hiraishi A., Park H.D. Dynamics of microcystin-degrading bacteria in mucilage of Microcystis. Microb. Ecol. 2003, 46:279-288.
21. Ho L., Hoefel D., Palazot S., Sawade E., Newcombe G., Saint C.P., Brookes J.D. Investigations into the biodegradation of microcystin-LR in wastewaters. J. Hazard. Mater. 2010, 180:628-633.
22. Jimbo Y., Okano K., Shimizu K., Maseda H., Fujimoto N., Utsumi M., Sugiura N. Quantification of microcystin-degrading bacteria in a biofilm from a practical biological treatment facility by real-time PCR. J. Water Environ. Technol. 2010, 8:193-201.
23. Li J., Shimizu K., Utsumi M., Nakamoto T., Sakharkar M.K., Zhang Z., Sugiura N. Dynamics of the functional gene copy number and overall bacterial community during microcystin-LR degradation by a biological treatment facility in a drinking water treatment plant. J. Biosci. Bioeng. 2011, 111:695-701.