Characterization of the aqueous iron(III) chelation chemistry of a potential Trojan Horse antimicrobial agent: Chelate structure, stability and pH dependent speciation

BioMetals

Volumn 25, Issue 5, 2012, Pages 1023-1036

  Harrington, James M ^a   Gootz, Tom ^b   Flanagan, Mark ^b   Lall, Majinder ^b   O'Donnell, John ^b   Winton, Jennifer ^b   Mueller, John ^b   Crumbliss, Alvin L ^a  

^a DUKE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

Antimicrobial; Chelation; Hydroxypyridinone; Iron; Redox; Siderophore; Trojan horse

Indexed keywords

3 HYDROXY, 4 PYRIDINONE GROUP; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; FERRIC ION; PIRAZMONAM; PYRIDONE DERIVATIVE; TROJAN HORSE DRUG; U 78606; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; COVALENT BOND; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRON CHELATION; LIGAND BINDING; MOLECULAR STABILITY; PH; POTENTIOMETRY; PROTON TRANSPORT; REDUCTION; SPECTROPHOTOMETRY; TANDEM MASS SPECTROMETRY;

ANTI-INFECTIVE AGENTS; BETA-LACTAMS; DRUG STABILITY; ELECTROCHEMICAL TECHNIQUES; FERRIC COMPOUNDS; HYDROGEN-ION CONCENTRATION; IRON CHELATING AGENTS; LIGANDS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; POTENTIOMETRY; SOLUTIONS; SPECTROPHOTOMETRY; WATER;

EQUIDAE;

EID: 84868093337     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9568-0     Document Type: Article

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