Sickle cell anemia: Iron availability and nocturnal oximetry

Journal of Clinical Sleep Medicine

Volumn 8, Issue 5, 2012, Pages 541-545

  Cox, Sharon E ^a,b   L'Esperance, Veline ^c   Makani, Julie ^b,d   Soka, Deogratius ^b   Prentice, Andrew M ^a   Hill, Catherine M ^c   Kirkham, Fenella J ^e  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Africa; Anemia; Hemoglobin saturation; Hypoxemia; Iron; Sickle cell

Indexed keywords

TRANSFERRIN;

ADOLESCENT; ALPHA THALASSEMIA; ARTICLE; BLOOD OXYGEN TENSION; BLOOD TRANSFUSION; CHILD; CLINICAL ARTICLE; CROSS-SECTIONAL STUDY; GENOTYPE; HUMAN; IRON DEFICIENCY; MALE; PRESCHOOL CHILD; PULSE OXIMETRY; SCHOOL CHILD; SICKLE CELL ANEMIA; STEADY STATE; TRANSFERRIN BLOOD LEVEL;

ADOLESCENT; ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HEMOGLOBINS; HUMANS; IRON; MALE; OXIMETRY; OXYGEN; POLYSOMNOGRAPHY; TRANSFERRIN;

EID: 84868093066     PISSN: 15509389     EISSN: 15509397     Source Type: Journal    
DOI: 10.5664/jcsm.2152     Document Type: Article

References (18)

1. Makani J, Cox SE, Soka D, et al. Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania. PLoS ONE 2011;6:e14699.
2. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev 2007;21:37-47.
3. Kirkham FJ, Datta AK. Hypoxic adaptation during development: relation to pattern of neurological presentation and cognitive disability. Dev Sci 2006;9:411-27.
4. Castro O, Poillon WN, Finke H, Massac E. Improvement of sickle cell anemia by iron-limited erythropoiesis. Am J Hematol 1994;47:74-81.
5. Ballas SK. Effect of alpha-globin genotype on the pathophysiology of sickle cell disease. Pediatr Pathol Mol Med 2001;20:107-21.
6. Quinn CT, Sargent JW. Daytime steady-state haemoglobin desaturation is a risk factor for overt stroke in children with sickle cell anaemia. Br J Haematol 2008;140:336-9.
7. Hargrave D, Wade A, Evans J, Hewes D, Kirkham F. Nocturnal hypoxemia and painful sickle cell crises in children. Blood 2003;101:846-8.
8. Setty BN, Stuart MJ, Dampier C, Brodecki D, Allen JL. Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology. Lancet 2003;362:1450-5.
9. Johnson MC, Kirkham FJ, Redline S, et al. Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation. Blood 2010;116:16-21.
10. Needleman JP, Franco ME, Varlotta L, et al. Mechanisms of nocturnal oxyhemoglobin desaturation in children and adolescents with sickle cell disease. Pediatr Pulmonol 1999;28:418-22.
11. Campbell A, Minniti CP, Nouraie M, et al. Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients. Br J Haematol 2009;147:352-9.
12. Minniti CP, Sable C, Campbell A, et al. Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation. Haematologica 2009;94:340-7.
13. Lulla RR, Thompson AA, Liem RI. Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease. Pediatr Blood Cancer 2010;55:141-4.
14. Koduri PR. Iron in sickle cell disease: a review why less is better. Am J Hematol 2003;73:59-63.
15. Kerstein R, Stimpson P, Caulfield H, Ellis G. Iron deficiency and sleep disordered breathing in children - cause or effect? Int J Pediatr Otorhinolaryngol 2009;73:275-80.
16. O'Brien LM, Koo J, Fan L, et al. Iron stores, periodic leg movements, and sleepiness in obstructive sleep apnea. J Clin Sleep Med 2009;5:525-31.
17. Semenza GL. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood 2009;114:2015-9.
18. Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respir Physiol Neurobiol 2008;164:277-81.