Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 6, 2012, Pages 912-918

  Hong, Jinpyo ^a   Kim, Bo Kyong ^a   Lim, Hyoungsub ^a   Lee, Soojin ^b   Lee, Sung Joong ^a  

^a Seoul National University   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Cytokine; Microglia; Necrotic neuronal cells; Neuronal cell death; Nitric oxide; Triamcinolone acetonide

Indexed keywords

AMCINONIDE; GAMMA INTERFERON; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; NITRIC OXIDE; TRIAMCINOLONE ACETONIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SYNTHESIS; IC 50; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DEATH; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CYTOKINES; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NEURONS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; SIGNAL TRANSDUCTION; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE;

EID: 84868091439     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2012.671332     Document Type: Article

References (31)

1. Block, M.L., Zecca, L., Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007, 8, 57-69.
2. Boje, K.M., Arora, P.K. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 1992, 587, 250-256.
3. Hong, J., Cho, I.H., Kwak, K.I., Suh, E.C., Seo, J., Min, H.J., Choi, S.Y., Kim, C.H., Park, S.H., Jo, E.K., Lee, S., Lee, K.E., Lee, S.J. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem 2010, 285, 39447-39457.
4. Nakanishi, H. Microglial functions and proteases. Mol Neurobiol 2003, 27, 163-176.
5. Du, Y., Ma, Z., Lin, S., Dodel, R.C., Gao, F., Bales, K.R., Triarhou, L.C., Chernet, E., Perry, K.W., Nelson, D.L., Luecke, S., Phebus, L.A., Bymaster, F.P., Paul, S.M. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001, 98, 14669-14674.
6. Malm, T.M., Magga, J., Kuh, G.F., Vatanen, T., Koistinaho, M., Koistinaho, J. Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease. Glia 2008, 56, 1767-1779.
7. Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.M., Iwata, N., Saido, T.C., Maeda, J., Suhara, T., Trojanowski, J.Q., Lee, V.M. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007, 53, 337-351.
8. Kim, D., Kim, M.A., Cho, I.H., Kim, M.S., Lee, S., Jo, E.K., Choi, S.Y., Park, K., Kim, J.S., Akira, S., Na, H.S., Oh, S.B., Lee, S.J. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem 2007, 282, 14975-14983.
9. Lv, M., Liu, Y., Zhang, J., Sun, L., Liu, Z., Zhang, S., Wang, B., Su, D., Su, Z. Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience 2011, 176, 162-172.
10. Francel, P.C., Harris, K., Smith, M., Fishman, M.C., Dawson, G., Miller, R.J. Neurochemical characteristics of a novel dorsal root ganglion X neuroblastoma hybrid cell line, F-11. J Neurochem 1987, 48, 1624-1631.
11. Lee, H., Jo, E.K., Choi, S.Y., Oh, S.B., Park, K., Kim, J.S., Lee, S.J. Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration. Biochem Biophys Res Commun 2006, 350, 742-747.
12. Cho, I.H., Hong, J., Suh, E.C., Kim, J.H., Lee, H., Lee, J.E., Lee, S., Kim, C.H., Kim, D.W., Jo, E.K., Lee, K.E., Karin, M., Lee, S.J. Role of microglial IKKß in kainic acid-induced hippocampal neuronal cell death. Brain 2008, 131, 3019-3033.
13. Livak, K.J., Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402-408.
14. Hains, B.C., Waxman, S.G. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 2006, 26, 4308-4317.
15. Lee, d.a.Y., Park, K.W., Jin, B.K. Thrombin induces neurodegeneration and microglial activation in the cortex in vivo and in vitro: proteolytic and non-proteolytic actions. Biochem Biophys Res Commun 2006, 346, 727-738.
16. Sohn, M.J., Noh, H.J., Yoo, I.D., Kim, W.G. Protective effect of radicicol against LPS/IFN-gamma-induced neuronal cell death in rat cortical neuron-glia cultures. Life Sci 2007, 80, 1706-1712.
17. Yu, H.H., Wu, F.L., Lin, S.E., Shen, L.J. Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOSmediated neurotoxicity in a coculture of neurons and microglia. J Neurosci Res 2008, 86, 2963-2972.
18. Jana, M., Liu, X., Koka, S., Ghosh, S., Petro, T.M., Pahan, K. Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells. J Biol Chem 2001, 276, 44527-44533.
19. Rasley, A., Anguita, J., Marriott, I. Borrelia burgdorferi induces inflammatory mediator production by murine microglia. J Neuroimmunol 2002, 130, 22-31.
20. Moriyama, N., Taniguchi, M., Miyano, K., Miyoshi, M., Watanabe, T. ANP inhibits LPS-induced stimulation of rat microglial cells by suppressing NF-κB and AP-1 activations. Biochem Biophys Res Commun 2006, 350, 322-328.
21. Zimmmerman TJ, Kooner KS, Sharir M, Fechtner RD. (1997). Textbook of ocular pharmacology. Philadelphia: Lippincoot-Raven, 683-684.
22. Li, H., Xie, W., Strong, J.A., Zhang, J.M. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain. Anesthesiology 2007, 107, 469-477.
23. Li, J.Y., Xie, W., Strong, J.A., Guo, Q.L., Zhang, J.M. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain. Reg Anesth Pain Med 2011, 36, 56-62.
24. Roesel, M., Gutfleisch, M., Heinz, C., Heimes, B., Zurek-Imhoff, B., Heiligenhaus, A. [Effect of intravitreal and orbital floor triamcinolone acetonide injection on intraocular inflammation in patients with active non-infectious uveitis]. Klin Monbl Augenheilkd 2009, 226, 110-114.
25. Mansoor, S., Kuppermann, B.D., Kenney, M.C. Intraocular sustained-release delivery systems for triamcinolone acetonide. Pharm Res 2009, 26, 770-784.
26. Hellwig, K., Stein, F.J., Przuntek, H., Müller, T. Efficacy of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients with spinal symptoms. BMC Neurol 2004, 4, 18.
27. Penfold, P.L., Wen, L., Madigan, M.C., King, N.J., Provis, J.M. Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Invest Ophthalmol Vis Sci 2002, 43, 3125-3130.
28. Wang, Y.S., Friedrichs, U., Eichler, W., Hoffmann, S., Wiedemann, P. Inhibitory effects of triamcinolone acetonide on bFGF-induced migration and tube formation in choroidal microvascular endothelial cells. Graefes Arch Clin Exp Ophthalmol 2002, 240, 42-48.
29. You, J.M., Yun, S.J., Nam, K.N., Kang, C., Won, R., Lee, E.H. Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures. Can J Physiol Pharmacol 2009, 87, 440-447.
30. Beg, A.A. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol 2002, 23, 509-512.
31. Rivest, S. Regulation of innate immune responses in the brain. Nat Rev Immunol 2009, 9, 429-439.