Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 79, Issue 7, 2007, Pages 513-523

  Higashiyama, Daisuke ^a   Saitsu, Hirotomo ^a   Komada, Munekazu ^a   Takigawa, Toshiya ^a   Ishibashi, Makoto ^a   Shiota, Kohei ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Ethanol; Holoprosencephaly; Mouse; Nkx2.1; Sonic Hedgehog; Teratogenic mechanism

Indexed keywords

ALCOHOL;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL TERATOGENESIS; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EMBRYO; FEMALE; GASTRULATION; GENE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HOLOPROSENCEPHALY; IN SITU HYBRIDIZATION; MOUSE; NKX2 1 GENE; NONHUMAN; PRIORITY JOURNAL; SHH GENE;

ABNORMALITIES, DRUG-INDUCED; ABNORMALITIES, MULTIPLE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; EMBRYONIC DEVELOPMENT; ETHANOL; FEMALE; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOLOPROSENCEPHALY; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PREGNANCY; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; ERINACEIDAE; MUS;

EID: 34447508442     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20367     Document Type: Article

References (61)

1. Ahlgren SC, Thakur V, Bronner-Fraser M. 2002. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc Natl Acad Sci USA 99:10476-10481.
2. Arenzana FJ, Carvan MJ, 3rd, Aijon J, et al. 2006. Teratogenic effects of ethanol exposure on zebrafish visual system development. Neurotoxicol Teratol 28:342-348.
3. Astley SJ, Magnuson SI, Omnell LM, et al. 1999. Fetal alcohol syndrome: changes in craniofacial form with age, cognition, and timing of ethanol exposure in the macaque. Teratology 59:163-172.
4. Bartholin L, Powers SE, Melhuish TA, et al. 2006. TGIF inhibits retinoid signaling. Mol Cell Biol 26:990-1001.
5. Belloni E, Muenke M, Roessler E, et al. 1996. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 14:353-356.
6. Blader P, Strähle U. 1998. Ethanol impairs migration of the prechordal plate in the zebrafish embryo. Dev Biol 201:185-201.
7. Bonnemann C, Meinecke P. 1990. Holoprosencephaly as a possible embryonic alcohol effect: another observation. Am J Med Genet 37:431-432.
8. Bupp Becker SR, Shibley IA, Jr. 1998. Teratogenicity of ethanol in different chicken strains. Alcohol Alcohol 33:457-464.
9. Cartwright MM, Smith SM. 1995a. Increased cell death and reduced neural crest cell numbers in ethanol-exposed embryos: partial basis for the fetal alcohol syndrome phenotype. Alcohol Clin Exp Res 19:378-386.
10. Cartwright MM, Smith SM. 1995b. Stage-dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome. Alcohol Clin Exp Res 19:1454-1462.
11. Charron F, Stein E, Jeong J, et al. 2003. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113:11-23.
12. Chen SY, Periasamy A, Yang B, et al. 2000. Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity. Alcohol 20:75-81.
13. Chen SY, Sulik KK. 1996. Free radicals and ethanol-induced cytotoxicity in neural crest cells. Alcohol Clin Exp Res 20:1071-1076.
14. Chiang C, Litingtung Y, Lee E, et al. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413.
15. Chrisman K, Kenney R, Comin J, et al. 2004. Gestational ethanol exposure disrupts the expression of FGF8 and Sonic hedgehog during limb patterning. Birth Defects Res A Clin Mol Teratol 70:163-171.
16. Cohen MM, Jr. 1989a. Perspectives on holoprosencephaly: Part I. Epidemiology, genetics, and syndromology. Teratology 40:211-235.
17. Cohen MM, Jr. 1989b. Perspectives on holoprosencephaly: Part III. Spectra, distinctions, continuities, and discontinuities. Am J Med Genet 34:271-288.
18. Cohen MM, Jr. 2001. Problems in the definition of holoprosencephaly. Am J Med Genet 103:183-187.
19. Cohen MM, Jr. 2003. The hedgehog signaling network. Am J Med Genet A 123:5-28.
20. Cohen MM, Jr. 2006. Holoprosencephaly: clinical, anatomic, and molecular dimensions. Birth Defects Res A Clin Mol Teratol 76:658-673.
21. Cohen MM, Jr., Shiota K. 2002. Teratogenesis of holoprosencephaly. Am J Med Genet 109:1-15.
22. Coulter CL, Leech RW, Schaefer GB, et al. 1993. Midline cerebral dysgenesis, dysfunction of the hypothalamic-pituitary axis, and fetal alcohol effects. Arch Neurol 50:771-775.
23. Da Lee R, Rhee GS, An SM, et al. 2004. Differential gene profiles in developing embryo and fetus after in utero exposure to ethanol. J Toxicol Environ Health A 67:2073-2084.
24. Dunty WC, Jr., Chen SY, Zucker KM, et al. 2001. Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications for alcohol-related birth defects and neurodevelopmental disorder. Alcohol Clin Exp Res 25:1523-1535.
25. Edison R, Muenke M. 2003. The interplay of genetic and environmental factors in craniofacial morphogenesis: holoprosencephaly and the role of cholesterol. Congenit Anom (Kyoto) 43:1-21.
26. Giknis ML, Damjanov I. 1980. The teratogenetic and embryonic effects of alcohol in four mouse strains. Teratology 21:40A (Abstract).
27. Goodrich LV, Jung D, Higgins KM, et al. 1999. Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev Biol 211:323-334.
28. Hard ML, Abdolell M, Robinson BH, et al. 2005. Gene-expression analysis after alcohol exposure in the developing mouse. J Lab Cli Med 145:47-54.
29. Helms JA, Kim CH, Hu D, et al. 1997. Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid. Dev Biol 187:25-35.
30. Ishibashi M, McMahon AP. 2002. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development 129:4807-4819.
31. Jellinger K, Gross H, Kaltenback E, et al. 1981. Holoprosencephaly and agenesis of the corpus callosum: frequency of associated malformations. Acta Neuropathol (Berl) 55:1-10.
32. Kotch LE, Sulik KK. 1992a. Patterns of ethanol-induced cell death in the developing nervous system of mice; neural fold states through the time of anterior neural tube closure. Int J Dev Neurosci 10:273-279.
33. Kotch LE, Sulik KK. 1992b. Experimental fetal alcohol syndrome: proposed pathogenic basis for a variety of associated facial and brain anomalies. Am J Med Genet 44:168-176.
34. Lagutin OV, Zhu CC, Kobayashi D, et al. 2003. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev 17:368-379.
35. Lupo G, Harris WA, Lewis KE. 2006. Mechanisms of ventral patterning in the vertebrate nervous system. Nat Rev Neurosci 7:103-114.
36. Majewski F. 1981. Alcohol embryopathy: some facts and speculations about pathogenesis. Neurobehav Toxicol Teratol 3:129-144.
37. Matsuo I, Kuratani S, Kimura C, et al. 1995. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev 9:2646-2658.
38. Ming JE, Muenke M. 2002. Multiple hits during early embryonic development: digenic diseases and holoprosencephaly. Am J Hum Genet 71:1017-1032.
39. Morriss-Kay G. 1993. Retinoic acid and craniofacial development: molecules and morphogenesis. Bioessays 15:9-15.
40. Nagai T, Aruga J, Minowa O, et al. 2000. Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci USA 97:1618-1623.
41. Parnell SE, Dehart DB, Wills TA, et al. 2006. Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect. Alcohol Clin Exp Res 30:1791-1798.
42. Parr BA, Shea MJ, Vassileva G, et al. 1993. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119:247-261.
43. Pfeiffer J, Majewski F, Fischbach H, et al. 1979. Alcohol embryo- and fetopathy. Neuropathology of 3 children and 3 fetuses. J Neurol Sci 41:125-137.
44. Roessler E, Belloni E, Gaudenz K, et al. 1996. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet 14:357-360.
45. Ronen GM, Andrews WL. 1991. Holoprosencephaly as a possible embryonic alcohol effect. Am J Med Genet 40:151-154.
46. Shen J, Walsh CA. 2005. Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol 25:3639-3647.
47. Shiota K, Nakatsu T, Irie H. 1993. Computerized three-dimensional reconstruction of normal and holoprosencephalic human embryos. Birth Defects: Orig Art Ser 29:253-263.
48. Siebert JR, Astley SJ, Clarren SK. 1991. Holoprosencephaly in a fetal macaque (Macaca nemestrina) following weekly exposure to ethanol. Teratology 44:29-36.
49. Sulik KK, Johnston MC. 1982. Embryonic origin of holoprosencephaly: interrelationship of the developing brain and face. Scan Electron Microsc Part 1:309-322.
50. Sulik KK, Johnston MC. 1983. Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome. Am J Anat 166:257-269.
51. Sulik KK, Johnston MC, Webb MA. 1981. Fetal alcohol syndrome: embryogenesis in a mouse model. Science 214:936-938.
52. Sussel L, Marin O, Kimura S, et al. 1999. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development 126:3359-3370.
53. Tian H, Tenzen T, McMahon AP. 2004. Dose dependency of Disp1 and genetic interaction between Displ and other hedgehog signaling components in the mouse. Development 131:4021-4033.
54. Wallis D, Muenke M. 2000. Mutations in holoprosencephaly. Hum Mutat 16:99-108.
55. Wallis DE, Muenke M. 1999. Molecular mechanisms of holoprosencephaly. Mol Genet Metab 68:126-138.
56. Wattendorf DJ, Muenke M. 2005. Fetal alcohol spectrum disorders. Am Fam Physician 72:279-282, 285.
57. Webster WS, Walsh DA, Lipson AH, et al. 1980. Teratogenesis after acute alcohol exposure in inbred and outbred mice. Neurobehav Toxicol 2:227-234.
58. Webster WS, Walsh DA, McEwen SE, et al. 1983. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome. Teratology 27:231-243.
59. Yamada S, Uwabe C, Fujii S, et al. 2004. Phenotypic variability in human embryonic holoprosencephaly in the Kyoto Collection. Birth Defects Res A Clin Mol Teratol 70:495-508.
60. Yamada Y, Nagase T, Nagase M, et al. 2005. Gene expression changes of Sonic hedgehog signaling cascade in a mouse embryonic model of fetal alcohol syndrome. J Craniofac Surg 16:1055-1061.
61. Zachman RD, Grummer MA. 2001. Prenatal ethanol consumption increases retinol and cellular retinol-binding protein expression in the rat fetal snout. Biol Neonate 80:152-157.