Formulation and optimization of celecoxib-loaded microspheres using response surface methodology

Tropical Journal of Pharmaceutical Research

Volumn 11, Issue 5, 2012, Pages 695-702

  Shahzad, M K ^a   Ubaid, M ^a,b   Murtaza, G ^b  

^a BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^b COMSATS Institute of Information Technology ^*  (Pakistan)

Author keywords

Celecoxib; Eudragit L 100; Microspheres; Polyvinyl pyrrolidone; Response surface methodology

Indexed keywords

CELECOXIB; EUDRAGIT; MICROSPHERE; POLYMER; POVIDONE;

ARTICLE; CLINICAL PROTOCOL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG FORMULATION; ENCAPSULATION; IN VITRO STUDY; MOLECULAR WEIGHT; PARTICLE SIZE; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RESPONSE SURFACE METHOD; SLOW DRUG RELEASE; STOMACH PH; STRUCTURE ANALYSIS;

EID: 84868035274     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bradley N. The response surface methodology. Master of Science Thesis, Indiana University of South Bend, USA, 2007.
2. Choonara YE, Pillay V, Charmicheal T, Danckwerts MP. Studies on a novel doughnut-shaped minitablet for intraocular drug delivery. AAPS pharmSciTech 2007; 8: E1-E7.
3. Mandal U, Gowda V, Ghosh A, Selvan S. Formulation and optimization of sustained release matrix tablets of Metformin HCl 500 mg using response surface methodology. The Pharm Soc Japan 2007; 127: 1281-1290.
4. Khan SA, Ahmad M, Murtaza G, Aamir MN, Akhtar N, Kousar R. Dual coated microparticles for intestinal delivery of nimesulide. Latin Am J Pharm 2011; 29: 739-745.
5. Aamir MN, Ahmad M, Khan SA, Akhtar N, Murtaza G, Akhtar M, Rasool F. Fabrication of novel gastro-retentive floating microcapsules by utilizing combination of HPMC and EC and their Physicochemical Assessment. Latin Am J Pharm 2011; 30: 1010-1015.
6. Khan SA, Ahmad M, Murtaza G, Aamir MN, Rasool F, Akhtar M. Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis. Latin Am J Pharm 2010; 29: 554-561.
7. Murtaza G. Development of glutaraldehyde crosslinked metronidazole loaded chitosan microcapsules: Analysis of dissolution data using DDSolver. Latin Am J Pharm 2011; 30: 1389-1395.
8. Murtaza G, Ahmad M. Microencapsulation of tramadol hydrochloride and physicochemical evaluation of formulations. Pak J Chem Soc 2009; 31: 511-519.
9. Khan SA, Ahmad M, Kousar R, Murtaza G. Nimesulide-serratiopeptidase sustained release microparticles-Combined formulation and in vitro characterization. Adv Clin Exp Med 2011; 20: 605-611.
10. Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM. Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatol 2007; 46: 135-140.
11. Murtaza G, Ahmad M, Akhtar N, Rasool F. A comparative study of various microencapsulation techniques: Effect of polymer viscosity on microcapsule characteristics. Pak J Pharm Sci 2009; 22: 291-300.
12. Tuncay M, Alis SC, Kas HS, Ercan MT, Peksoy I, Hincal AA. Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and In vitro:in vivo evaluation. Int J Pharm 2000; 195: 179-188
13. Khan SA, Ahmad M, Kousar R, Murtaza G. Nimesulide-serratiopeptidase sustained release microparticles-Combined formulation and in vitro characterization. Adv Clin Exp Med 2011; 20: 605-611.
14. Najib N, Suleiman M. The kinetics of drug release from ethyl cellulose solid dispersion. Drug Dev Ind Pharm 1985; 11: 2169-2189.
15. Giannola LI, De Caro V, Rizzo MC. Preparation of White Beeswax Microspheres loaded with Valproic Acid and Kinetic Study of Drug Release. Drug Dev Ind Pharm 1995; 21: 797-807.
16. Varshosaz J, Keihanfar M. Development and evaluation of sustained-release propranolol wax microspheres. J Microencapsul 2001; 18: 277-84.
17. Babu VR, Reddy KM, Sairam M, Subha MCS, Mallikarjuna NN, Kulkarni PV, Aminabhavi TM Des Monomers Polymers.2007; 10: 155-165.
18. Aceves JM, Cruz R, Hernandez E. Preparation and characterization of Furosemide-Eudragit controlled release systems. Int J Pharm 2000; 195: 45-53.
19. Bikiaris D, Papageorgiou GZ, Stergiou A, Pavlidou E, Karavas E, Kanaze F, Georgarakis M. Physicochemical studies on solid dispersions of poorly water-soluble drugs: Evaluation of capabilities and limitations of thermal analysis techniques. Thermochim Acta 2005; 439: 58-67.
20. Ansari MT, Haneef M, Murtaza G. Solid Dispersions of Artemisinin in Polyvinyl Pyrrolidone and Polyethylene Glycol. Adv Clin Exp Med 2010; 19: 745-754.