Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 11, 2012, Pages 5839-5844

  Beenken, Karen E ^a   Bradney, Laura ^a   Bellamy, William ^a   Skinner, Robert A ^a   McLaren, Sandra G ^a   Gruenwald, M Johannes ^a   Spencer, Horace J ^a   Smith, James K ^b   Haggard, Warren O ^b   Smeltzer, Mark S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b University of Memphis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE CEMENT; DAPTOMYCIN; POLY(METHYL METHACRYLATE); XYLITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; BONE INFECTION; CHRONIC OSTEOMYELITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEBRIDEMENT; DRUG EFFICACY; ELUTION; IN VIVO STUDY; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RABBIT; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE CEMENTS; CHRONIC DISEASE; DAPTOMYCIN; DEBRIDEMENT; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; HUMANS; MALE; OSTEOMYELITIS; POLYMETHYL METHACRYLATE; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; XYLITOL;

EID: 84868028782     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01127-12     Document Type: Article

References (21)

1. Anagnostakos K, Kelm J. 2009. Enhancement of antibiotic elution from acrylic bone cement. J. Biomed. Mater. Res. B Appl. Biomater. 90:467-475.
2. Badet C, Furiga A, Thébaud N. 2008. Effect of xylitol on an in vitro model of oral biofilm. Oral Health Prev. Dent. 6:337-341.
3. Boyd N, Nailor MD. 2011. Combination antibiotic therapy for empiric and definitive treatment of gram-negative infections: insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 31:1073-1084.
4. Brady RA, Leid JG, Calhoun JH, Costerton JW, Shirtliff ME. 2008. Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunol. Med. Microbiol. 52:13-22.
5. Cierny G. 2011. Surgical treatment of osteomyelitis. Plast. Reconstr. Surg. 127:190S-204S.
6. El-Husseiny M, Patel S, MacFarlane RJ, Haddad FS. 2011. Biodegradable antibiotic delivery systems. J. Bone Joint Surg. Br. 93:151-157.
7. Gillaspy AF, et al. 1995. Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect. Immun. 63:3373-3380.
8. Katsuyama M, Ichikawa H, Ogawa S, Ikezawa Z. 2005. A novel method to control the balance of skin microflora. Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. J. Dermatol. Sci. 38:197-205.
9. Kurola P, et al. 2011. Effect of xylitol and other carbon sources on Streptococcus pneumoniae biofilm formation and gene expression in vitro. APMIS 119:135-142.
10. Lew DP, Waldvogel FA. 2004. Osteomyelitis. Lancet 364:369-379.
11. Mattila PT, Svanberg MJ, Knuuttila ML. 2001. Increased bone volume and bone mineral content in xylitol-fed aged rats. Gerontology 47:300-305.
12. McLaren AC, Nelson CL, McLaren SG, DeClerk GR. 2004. The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: a pilot study. Clin. Orthop. Relat. Res. 427:25-27.
13. McLaren AC, McLaren SG, Smeltzer M. 2006. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin. Orthop. Relat. Res. 451:25-28.
14. McLaren AC, McLaren SG, Hickmon MK. 2007. Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics. Clin. Orthop. Relat. Res. 461:60-63.
15. McLaren AC, McLaren SG, McLemore R, Vernon BL. 2007. Particle size of fillers affects permeability of polymethylmethacrylate. Clin. Orthop. Relat. Res. 461:64-67.
16. Rao N, Ziran BH, Lipsky BA. 2011. Treating osteomyelitis: antibiotics and surgery. Plast. Reconstr. Surg. 127:177S-187S.
17. Renko M, et al. 2008. Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis. BMC Microbiol. 8:45. doi:10.1186/1471-2180-8-45.
18. Sato H, Ide Y, Nasu M, Numabe Y. 2011. The effects of oral xylitol administration on bone density in rat femur. Odontology 99:28-33.
19. Smeltzer MS, et al. 1997. Characterization of a rabbit model of staphylococcal osteomyelitis. J. Orthop. Res. 15:414-421.
20. Söderling EM, Ekman TC, Taipale TJ. 2008. Growth inhibition of Streptococcus mutans with low xylitol concentrations. Curr. Microbiol. 56:382-385.
21. Weiss BD, et al. 2009. Optimized elution of daptomycin from polymeth-ylmethacrylate beads. Antimicrob. Agents Chemother. 53:264-266.