STW 5 is effective in dextran sulfate sodium-induced colitis in rats

International Journal of Colorectal Disease

Volumn 27, Issue 11, 2012, Pages 1445-1453

  Wadie, Walaa ^a   Abdel Aziz, Heba ^b   Zaki, Hala F ^a   Kelber, Olaf ^c   Weiser, Dieter ^c   Khayyal, Mohamed T ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c Steigerwald Arzneimittelwerk GmbH   (Germany)

Author keywords

Colonic responsiveness; Cytokines; DSS colitis; STW 5

Indexed keywords

CARBACHOL; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 3; DEXTRAN SULFATE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HERBACEOUS AGENT; IBEROGAST; MYELOPEROXIDASE; POTASSIUM CHLORIDE; SALAZOSULFAPYRIDINE; STW 5; SUPEROXIDE DISMUTASE; TRYPSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON MOTILITY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG EFFICACY; EX VIVO STUDY; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ULCERATIVE COLITIS;

ANIMALS; BODY WEIGHT; COLITIS; COLON; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MOTILITY; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INFLAMMATION; MALE; ORGAN SIZE; PLANT EXTRACTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 84868001761     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-012-1473-z     Document Type: Article

References (41)

1. Collins SM (1996) The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders. Gastroenterol 111:1683-1699
2. Collins SM, Van Assche G, Hogaboam C (1997) Alterations in enteric nerve and smooth-muscle function in inflammatory bowel diseases. Inflam Bowel Dis 3:38-48
3. Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE, Büchler MW (2000) Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency. Digestion 62:240-248
4. Frias R, Ouwehand A, Spillmann T, Vankerckhovend V, Hewicker-Trautweine M, Salminenc S, Gueimonde M (2009) Effect of clinical and probiotic Lactobacillus rhamnosus strains on intestinal permeability and bacterial translocation in healthy and colitic rats. Food Res Int 42:636-640
5. Rösch W, Liebregts T, Gundermann KJ, Vinson B, Holtmann G (2006) Phytotherapy for functional dyspepsia: A review of the clinical evidence for the herbal preparation STW 5. Phytomedicine 13:114-121
6. Madisch A, Holtmann G, Plein K, Hotz J (2004) Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial. Aliment Pharmacol Ther 19:271-279
7. Madisch A, Holtmann G, Mayr G, Vinson B, Hotz J (2004) Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 69:45-52
8. Khayyal MT, El-Ghazaly MA, Kenawy SA, Seif-el-Nasr M, Mahran LG, Kafafi YA, Okpanyi SN (2001) Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination. Arzneimittelforschung 51:545-553
9. Khayyal MT, Seif-El-Nasr M, El-Ghazaly MA, Okpanyi SN, Kelber O, Weiser D (2006) Mechanisms involved in the gastroprotective effect of STW 5 (Iberogast) and its components against ulcers and rebound acidity. Phytomedicine 13:56-66
10. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882-888
11. Krawisz JE, Sharon P, Stenson WF (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87:1344-1350
12. Shin EK, Kwon H, Kim YH, Shin HK, Kim JK (2009) Chrysin, a natural flavone, improves murine inflammatory bowel diseases. Biochem Biophys Res Commun 381:502-507
13. Klein S, Meyers S, O'Sullivan P, Barton D, Leleiko N, Janowitz HD (1988) The metabolic impact of active ulcerative colitis. Energy expenditure and nitrogen balance. J Clin Gastroenterol 10:34-40
14. Rigaud D, Angel LA, Cerf M, Carduner MJ, Melchior JC, Sautier C, René E, Apfelbaum M, Mignon M (1994) Mechanisms of decreased food intake during weight loss in adult Crohn's disease patients without obvious malabsorption. Am J Clin Nutr 60:775-781
15. Geier MS, Butler RN, Giffard PM, Howarth GS (2007) Lactobacillus fermentum BR11, a potential new probiotic, alleviates symptoms of colitis induced by dextran sulfate sodium (DSS) in rats. Int J Food Microbiol 114:267-274
16. Kraft SC, Kirsner JB (1971) Immunological apparatus of the gut and inflammatory bowel disease. Gastroenterol 60:922-951
17. Villegas I, Alarcón de la Lastra C, Orjales A, La Casa C (2003) A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice. Int Immunopharmacol 3:1731-1741
18. Lau D, Mollnau H, Eiserich JP, Freeman BA, Daiber A, Gehling UM, Brümmer J, Rudolph V, Münzel T, Heitzer T, Meinertz T, Baldus S (2005) Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci U S A 102:431-436
19. Abdel-Aziz H, Zaki HF, Neuhuber W, Kelber O, Weiser D, Khayyal MT (2010) Effect of an herbal preparation, STW 5, in an acute model of reflux oesophagitis in rats. J Pharmacol Sci 113:134-142
20. Arafa HM, Hemeida RA, El-Bahrawy AI, Hamada FM (2009) Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model. Food Chem Toxicol 47:1311-1317
21. Camuesco D, Comalada M, Rodríguez-Cabezas ME, Nieto A, Lorente MD, Concha A, Zarzuelo A, Gálvez J (2004) The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br J Pharmacol 143: 908-918
22. D'Odorico A, Bortolan S, Cardin R, D'Inca R, Martines D, Ferronato A, Sturniolo GC (2001) Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 36:1289-1294
23. Germann I, Hagelauer D, Kelber O, Vinson B, Laufer S, Weiser D, Heinle H (2006) Antioxidative properties of the gastrointestinal phytopharmaceutical remedy STW 5 (Iberogast). Phytomedicine 13:45-50
24. Schempp H, Weiser D, Kelber O, Elstner EF (2006) Radical scavenging and anti-inflammatory properties of STW 5 (Iberogast) and its components. Phytomedicine 13:36-44
25. Lee M, Kovacs-Nolan J, Archbold T, Fan MZ, Juneja LR, Okubo T, Mine Y (2009) Therapeutic potential of hen egg white peptides for the treatment of intestinal inflammation. J Funct Foods 1:161-169
26. Triantafillidis JK, Merikas E, Georgopoulos F (2011) Current and emerging drugs for the treatment of inflammatory bowel disease. Drug Des Devel Ther 5:185-210
27. Begue B, Wajant H, Bambou JC, Dubuquoy L, Siegmund D, Beaulieu JF, Canioni D, Berrebi D, Brousse N, Desreumaux P, Schmitz J, Lentze MJ, Goulet O, Cerf-Bensussan N, Ruemmele FM (2006) Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions. Gastroenterol 130:1962-1974
28. MacDermott RP (1996) Alterations of the mucosal immune system in inflammatory bowel disease. J Gastroenterol 31:907-916
29. Umehara Y, Kudo M, Nakaoka R, Kawasaki T, Shiomi M (2006) Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. Hepatogastroenterology 53:879-882
30. Michael S, Kelber O, Hauschildt S, Spanel-Borowski K, Nieber K (2009) Inhibition of inflammation-induced alterations in rat small intestine by the herbal preparations STW 5 and STW 6. Phytomedicine 16:161-171
31. Bonaterra GA, Kelber O, Kinscherf R, Traut U, Seitz S, Weiser D and Metz J (2008) Anti-inflammatory and anti-cancer effects of the phytomedicine STW 5 and its components in vitro. Planta Med 74: PA295
32. Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8:837-848
33. Snape WJ Jr, Kao HW (1988) Role of inflammatory mediators in colonic smooth muscle function in ulcerative colitis. Dig Dis Sci 33(Suppl 3):65S-70S
34. Snape WJ Jr, Williams R, Hyman PE (1991) Defect in colonic smooth muscle contraction in patients with ulcerative colitis. Am J Physiol 261:G987-G991
35. Grossi L, McHugh K, Collins SM (1993) On the specificity of altered muscle function in experimental colitis in rats. Gastroenterol 104:1049-1056
36. Wells RW, Blennerhassett MG (2004) Persistent and selective effects of inflammation on smooth muscle cell contractility in rat colitis. Pflugers Arch 448:515-524
37. Al-Jarallah A, Oriowo MA, Khan I (2007) Mechanism of reduced colonic contractility in experimental colitis: Role of sarcoplasmic reticulum pump isoform-2. Mol Cell Biochem 298:169-178
38. Liu X, Rusch NJ, Striessnig J, Sarna SK (2001) Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterol 120:480-489
39. Kinoshita K, Sato K, Hori M, Ozaki H, Karaki H (2003) Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model. Am J Physiol Gastrointest Liver Physiol 285:G483-G493
40. Ammon HP, Kelber O, Okpanyi SN (2006) Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle. Phytomedicine 13:67-74
41. Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D (2006) Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinicM3, and opioid receptors. Phytomedicine 13:51-55