Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children

Cytokine

Volumn 60, Issue 3, 2012, Pages 634-638

  Voruganti, V Saroja ^a   Laston, Sandra ^a   Haack, Karin ^a   Mehta, Nitesh R ^b   Smith, C Wayne ^b   Cole, Shelley A ^a   Butte, Nancy F ^b   Comuzzie, Anthony G ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Effect size; Inflammation; Obesity; Polymorphism; Variance

Indexed keywords

ASPARTIC ACID; GLYCINE; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADOLESCENT; ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CASPASE RECRUITMENT DOMAIN FAMILY MEMBER 9 GENE; CHEMOKINE RECEPTOR 3 GENE; CHILD; CHROMOSOME 1; COHORT ANALYSIS; DUFFY ANTIGEN RECEPTOR FOR CHEMOKINE GENE; FAMILY RELATION; FAMILY STUDY; GENE; GENE FREQUENCY; GENE PRODUCT; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HISPANIC; HUMAN; HUMAN GENOME; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MONOCYTE CHEMOTACTIC PROTEIN 1 BLOOD LEVEL; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS; REPLICATION STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AMINO ACID SUBSTITUTION; CARD SIGNALING ADAPTOR PROTEINS; CHEMOKINE CCL2; CHILD; CHILD, PRESCHOOL; DUFFY BLOOD-GROUP SYSTEM; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HISPANIC AMERICANS; HUMANS; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CCR3; RECEPTORS, CELL SURFACE; YOUNG ADULT;

EID: 84867999363     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.08.029     Document Type: Article

References (34)

1. Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K., Kitazawa R., et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006, 116:1494-1505.
2. Maffei M., Funicello M., Vottari T., Gamucci O., Costa M., Lisi S., et al. The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2). BMC Biol 2009, 2009(7):87.
3. Hotamisligil G.S. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005, 54(Suppl2):S73-S78.
4. Murdoch C., Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood 2000, 95:3032-3043.
5. Xu L., Ashkenzi A., Chaudhari A. Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis 2007, 10:307-318.
6. Dahlman I., Kaaman M., Olsson T., Tan G.D., Beckerton A.S., Wahlen K., et al. A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 2005, 90:5834-5840.
7. Weisberg S.P., Hunter D., Huber R., Lemieux J., Slaymaker S., Vaddi K., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006, 116:115-124.
8. Huber J., Kiefer F.W., Zeyda M., Ludvik B., Silberhumer G.R., Prager G., et al. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J Clin Endocrinol Metab 2008, 93:3215-3221.
9. Rull A., Camps J., Alonso-Villaverde C., Joven J. Insulin resistance, inflammation and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism. Mediators Inflamm 2010, [pii326580].
10. Cai G., Cole S.A., Butte N.F., Smith C.W., Mehta N.R., Voruganti V.S., et al. A genetic contribution to circulating cytokines and obesity in children. Cytokine 2008, 44:242-247.
11. Butte N.F., Cai G., Cole S.A., Comuzzie A.G. Viva la Familia Study: genetic and environmental contributions to childhood obesity and its comorbidities in the Hispanic population. Am J Clin Nutr 2006, 84:646-654.
12. Sobel E., Lange K. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics. Am J Hum Genet 1996, 58:1323-1337.
13. Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998, 62:1198-1211.
14. Boerwinkle E., Chakraborty R., Sing C.F. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet 1986, 50:181-194.
15. Schnabel R.B., Baumert J., Barbalic M., Dupuis J., Ellinor P.T., Durda P., et al. Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators. Blood 2010, 115:5289-5299.
16. Chanock S.J. The DARC side of GWAS. Blood 2010, 115:5285-5286.
17. Benjamin E.J., Dupuis J., Larson M.G., Lunetta K.L., Booth S.L., Govindaraju D.R., et al. Genome-wide association with select biomarker traits in the Framingham heart study. BMC Med Genet 2007, 8(Suppl1):S11.
18. Naitza S., Porcu E., Steri M., Taub D.D., Mulas A., Xiao X., et al. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genetics 2012, 8:e1002480.
19. Gosset P., Tillie-Leblond I., Oudin S., Parmentier O., Wallaert B., Tonnel Joseph M., et al. Production of chemokines and proinflammatory amd anti-inflammatory cytokines by human alveolar macrophages activated by IgE receptors. J Allergy Clin Immunol 1999, 103:289-297.
20. Eglite S., Morin J.M., Metzger H. Synthesis and secretion of monocyte chemotactic protein-1 stimulated by the high affinity receptor for IgE. J Immunol 2003, 170:2680-2687.
21. Ito A., Suganami T., Miyamoto Y., Yoshimasa Y., Takeya M., Kamei Y., et al. Role of MAPK Phosphatase-1 in the induction of monocyte cehmoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem 2007, 282:25445-25452.
22. Malavazos A.E., Cereda E., Morricone L., Coman C., Corsi M.M., Ambrosi B. Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity. Eur J Endocrinol 2005, 153(6):871-877.
23. Breslin W.L., Johnston C.A., Strohacker K., Carpenter K.C., Davidson T.R., Moreno J.P., et al. Obese Mexican American children have elevated MCP-1, TNF-α, monocyte concentration and dyslipidemia. Pediatrics 2012, 129:e1180-1186.
24. Harsimran K., Singh A.A., Guruvinder S., Sharda S., Vasudha S. Plasma monocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians. Diabetes Vasc Dis Res 2009, 6:288-290.
25. Zineh I., Beitelshees A.L., Silverstein J.H., Haller M.J. Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes. Diabetes Care 2009, 32:465-467.
26. Zeyda M., Gollinger K., Kriehuber E., Kiefer F.W., Neuhofer A., Stulnig T.M. Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression. Int J Obesity 2010, 34:1684-1694.
27. Hsu Y.-M.S., Zhang Y., You Y., Wang D., Li H., Duramand O., et al. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nature Immun 2007, 8:198-205.
28. Pruenster M., Rot A. Throwing light on DARC. Biochem Soc Trans 2006, 34:12-19. [part 6].
29. Zarbock A., Bishop J., Muller H., Schmolke M., Buschmann K., Van Aken H. Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokines. Am J Physiol Lung Cell Mol Physiol 2010, 298:L462-L471.
30. Dawson T., Lentsch A.B., Wang Z., Cowhig J.E., Rot A., Maeda N., et al. Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood 2000, 96:1681-1684.
31. He W., Neil S., Kulkarni H., Wright E., Agan B.K., Marconi V.C., et al. Duffy antigen receptor for chemokines mediates trans -infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell Host Microbe 2008, 4:52-62.
32. Pogo A.O., Chaudhari A. The Duffy protein: a malarial and chemokine receptor. Semin Hematol 2000, 37:122-129.
33. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.
34. Liu X.H., Hadley T.J., Xu L., Peiper S.C., Ray P.E. Up-regulation of Duffy antigen receptor expression in children with renal disease. Kidney Int 1999, 55:1491-1500.