IgA is important for clearance and critical for protection from rotavirus infection

Mucosal Immunology

Volumn 5, Issue 6, 2012, Pages 712-719

  Blutt, S E ^a   Miller, A D ^a   Salmon, S L ^b   Metzger, D W ^b   Conner, M E ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84867959916     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.51     Document Type: Article

References (33)

1. Janeway, C., Travers, P., Walport, M. & Shlomckik, J. Immunobiology: The Immune System in Health and Disease (Elsevier Science/Garland Publishing, London, 2001).
2. Mestecky, J., Moro, I. & Underdown, J. Mucosal immunoglobins. In Mucosal Immunology (Ogra, P., et al., eds) 133-152 (Academic Press, San Diego, 1999).
3. Cerutti, A., Chen, K. & Chorny, A. Immunoglobulin responses at the mucosal interface. Annu. Rev. Immunol. 29, 273-293 (2011).
4. Yel, L. Selective IgA defi ciency. J. Clin. Immunol. 30, 10-16 (2010).
5. Harriman, G. R. et al. Targeted deletion of the IgA constant region in mice leads to IgA defi ciency with alterations in expression of other ig isotypes. J. Immunol 162, 2521-2529 (1999). (Pubitemid 29309269)
6. Blanchard, T. G. et al. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice. Cell Immunol. 191, 74-80 (1999). (Pubitemid 29054969)
7. Parr, M. B., Harriman, G. R. & Parr, E. L. Immunity to vaginal HSV-2 infection in immunoglobulin A knockout mice. Immunology 95, 208-213 (1998). (Pubitemid 28459383)
8. Mbawuike, I. N. et al. Mucosal immunity to infl uenza without IgA: an IgA knockout mouse model. J. Immunol. 162, 2530-2537 (1999). (Pubitemid 29309270)
9. Silvey, K. J., Hutchings, A. B., Vajdy, M., Petzke, M. M. & Neutra, M. R. Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches. J. Virol. 75, 10870-10879 (2001). (Pubitemid 33031555)
10. Estes, M. K. & Kapikian, A. Z. Field's virology. In (Knipe, D.M. & Howley, P. M. eds) 1917-1974 (Lippincott-Raven Publishers, Philadelphia, 2007).
11. O 'Neal, C. M., Harriman, G. R. & Conner, M. E. Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobin A. J. Virol. 74, 4102-4109 (2000). (Pubitemid 30214415)
12. Kuklin, N. A. et al. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production. J. Immunol. 166, 1894-1902 (2001). (Pubitemid 32114676)
13. Franco, M. A. & Greenberg, H. B. Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice. J. Virol. 69, 7800-7806 (1995).
14. McNeal, M. M., Barone, K. S., Rae, M. N. & Ward, R. L. Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice. Virology 214, 387-397 (1995).
15. Marcelin, G., Miller, A. D., Blutt, S. E. & Conner, M. E. Immune mediators of rotavirus antigenemia clearance in mice. J. Virol. 85, 7937-7941 (2011).
16. Burns, J. W., Siadat-Pajouh, M., Krishnaney, A. A. & Greenberg, H. B. Protective effect of rotavirus VP6-specifi c IgA monoclonal antibodies that lack neutralizing activity. Science 272, 104 (1996).
17. McNeal, M. M. et al. Protection against rotavirus shedding after intranasal immunization of mice with a chimeric VP6 protein does not require intestinal IgA. Virology 346, 338-347 (2006). (Pubitemid 43357877)
18. Schwartz-Cornil, I., Benureau, Y., Greenberg, H., Hendrickson, B. A. & Cohen, J. Heterologous protection induced by the inner capsid proteins of rotavirus requires transcytosis of mucosal immunoglobulins. J. Virol. 76 , 8110-8117 (2002). (Pubitemid 34809065)
19. Brandtzaeg, P. & Prydz, H. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 311, 71-73 (1984). (Pubitemid 14065284)
20. Blutt, S. E., Warfi eld, K. L., O 'Neal, C. M., Estes, M. K. & Conner, M. E. Host, viral, and vaccine factors that determine protective effi cacy induced by rotavirus and virus-like particles (VLPs). Vaccine 24, 1170-1179 (2006). (Pubitemid 43202263)
21. Sanford, L. P., Kallapur, S., Ormsby, I. & Doetschman, T. Infl uence of genetic background on knockout mouse phenotypes. Methods Mol. Biol. 158, 217-225 (2001).
22. Franco, M. A. & Greenberg, H. B. Immunity to homologous rotavirus infection in adult mice. Trends Microbiol. 8, 50-52 (2000). (Pubitemid 30100317)
23. Blutt, S. E. & Conner, M. E. Rotavirus: to the gut and beyond!. Curr. Opin. Gastroenterol. 23, 39-43 (2007). (Pubitemid 44875908)
24. O 'Neal, C. M., Crawford, S. E., Estes, M. K. & Conner, M. E. Rotavirus VLPs administered mucosally induce protective immunity. J. Virol. 71 , 8707-8717 (1997). (Pubitemid 27446453)
25. Uren, T. K. et al. Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies. Eur. J. Immunol. 35, 180-188 (2005). (Pubitemid 40123864)
26. Wijburg, O. L. et al. Innate secretory antibodies protect against natural Salmonella typhimurium infection. J. Exp. Med. 203, 21-26 (2006). (Pubitemid 43139640)
27. Silvey, K. J., Hutchings, A. B., Vajdy, M., Petzke, M. M. & Neutra, M. R. Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches. J. Virol. 75, 10870-10879 (2001). (Pubitemid 33031555)
28. Brandtzaeg, P. et al. The clinical condition of IgA-defi cient patients is related to the proportion of IgD-and IgM-producing cells in their nasal mucosa. Clin. Exp. Immunol. 67, 626-636 (1987). (Pubitemid 17031806)
29. Reading, N. C. & Kasper, D. L. The starting lineup: key microbial players in intestinal immunity and homeostasis. Front. Microbiol. 2, 148 (2011).
30. Bernasconi, N. L., Traggiai, E. & Lanzavecchia, A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202 (2002). (Pubitemid 35471246)
31. Blutt, S. E. et al. Rotavirus antigenaemia and viraemia: a common event? Lancet 362, 1445-1449 (2003). (Pubitemid 37352880)
32. Coulson, B. S. et al. Comparison of rotavirus immunoglobulin A coproconversion with other indices of rotavirus infection in a longitudinal study in childhood. J. Clin. Microbiol. 28, 1367-1374 (1990). (Pubitemid 20194433)
33. Sandler, R. S. et al. The burden of selected digestive diseases in the United States. Gastroenterology 122, 1500-1511 (2002). (Pubitemid 34465190)