Nitric oxide-releasing nanoparticles: Challenges and future prospects

Therapeutic Delivery

Volumn 3, Issue 10, 2012, Pages 1139-1142

  Martinez, Luis R ^a,b  

^a LONG ISLAND UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

antimicrobial agent; nanotechnology; nitric oxide; wound healing

Indexed keywords

CHITOSAN; GLUTATHIONE; MACROGOL; NANOPARTICLE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; S NITROSOGLUTATHIONE;

ABSCESS; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ANTIMICROBIAL ACTIVITY; BACTERIAL SKIN DISEASE; BIOFILM; BURN; BURN INFECTION; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED DRUG RELEASE; EDITORIAL; HUMAN; HYDROGEL; INTRAMUSCULAR ABSCESS; LIPOPHILICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NANOENCAPSULATION; NONHUMAN; OXIDATION REDUCTION REACTION; POWDER; PRIORITY JOURNAL; SKIN INFECTION; SOLDIER; THERMOSTABILITY; WOUND; WOUND HEALING; WOUND INFECTION;

EID: 84867936691     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.12.97     Document Type: Editorial

References (18)

1. Weller R. Nitric oxide: A key mediator in cutaneous physiology. Clin. Exp. Dermatol. 28(5), 511-514 (2003
2. Friedman AJ, Han G, Navati MS et al. Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites. Nitric Oxide 19(1), 12-20 (2008
3. Navati MS, Friedman JM. Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances. J. Biol. Chem. 281(47), 36021-36028 (2006
4. Rabea EI, Badawy ME, Stevens CV, Smagghe G, Steurbaut W. Chitosan as antimicrobial agent: Applications and mode of action. Biomacromolecules 4(6), 1457-1465 (2003
5. Friedman AJ, Blecher K, Schairer D et al. Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. Nitric Oxide 25(4), 381-386 (2011
6. Cabrales P. Nanoengineering bactericidal nitric oxide therapies. Virulence 2(3), 185-187 (2011
7. Fang FC. Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies. Nat. Rev. Microbiol. 2(10), 820-832 (2004
8. Martinez LR, Han G, Chacko M et al. Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J. Invest. Dermatol. 129(10), 2463-2469 (2009
9. George Han, Martinez LR, Mihu MR et al. Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection. Plos One 4(11), e7804 (2009
10. Schairer D, Martinez LR, Blecher K et al. Nitric oxide nanoparticles: Pre-clinical utility as a therapeutic for intramuscular abscesses. Virulence 3(1), 62-67 (2012
11. Mihu MR, Martinez LR. Novel therapies for treatment of multi-drug resistant Acinetobacter baumannii skin infections. Virulence 2(2), 97-102 (2011
12. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: Emergence of a successful pathogen. Clin. Microbiol. Rev. 21(3), 538-582 (2008
13. Mihu MR, Sandkovsky U, Han G, Friedman JM, Nosanchuk JD, Martinez LR. The use of nitric oxide releasing nanoparticles as a treatment against Acinetobacter baumannii in wound infections. Virulence 1(2), 62-67 (2010
14. Macherla C, Sanchez DA, Ahmadi MS et al. Nitric oxide releasing nanoparticles for treatment of Candida albicans burn infections. Front. Microbio. 3, 193 (2012
15. Yamasaki K, Edington HD, McClosky C et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J. Clin. Invest. 101(5), 967-971 (1998
16. Han G, Nguyen LN, Macherla C et al. Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am. J. Pathol. 180(4), 1465-1473 (2012
17. Blecher K, Martinez LR, Tuckman-Vernon C et al. Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice. Nanomedicine (2012) (In Press
18. Trampuz A, Zimmerli W. New strategies for the treatment of infections associated with prosthetic joints. Curr. Opin. Invest. Drugs 6(2), 185-190 (2005