Evaluation of calcineurin/NFAT inhibitor selectivity in primary human Th cells using bar-coding and phospho-flow cytometry

Cytometry Part A

Volumn 81 A, Issue 11, 2012, Pages 1005-1011

  Frischbutter, Stefan ^a   Schultheis, Katherine ^a   Pätzel, Michael ^b   Radbruch, Andreas ^a,c   Baumgrass, Ria ^a  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cell activation; Small molecular inhibitors; TCR signaling; Transcription factors

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARACHIDONIC ACID DERIVATIVE; CALCINEURIN; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (4 HYDROXYPHENYL)ARACHIDONYLAMIDE; N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE; NITRILE; PYRIDINE DERIVATIVE; SULFONE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR RELA;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FLOW CYTOMETRY; FLUORESCENCE; HELPER CELL; HUMAN; IC 50; INFORMATION PROCESSING; METABOLISM; METHODOLOGY; PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ARACHIDONIC ACIDS; AUTOMATIC DATA PROCESSING; CALCINEURIN; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; FLUORESCENCE; GENES, REPORTER; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MAP KINASE SIGNALING SYSTEM; NFATC TRANSCRIPTION FACTORS; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; SULFONES; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTOR RELA;

EID: 84867920258     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22204     Document Type: Article

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