Investigating intergenerational differences in human PCB exposure due to variable emissions and reproductive behaviors

Environmental Health Perspectives

Volumn 119, Issue 5, 2011, Pages 641-646

  Quinn, Cristina L ^a   Wania, Frank ^a   Czub, Gertje ^b   Breivik, Knut ^c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b Swedish Chemicals Agency   (Sweden)

^c NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Environmental fate; Human exposure; Modeling organic contaminants; PCBs; Reproductive characteristics; Time variant emissions

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; LIPID; POLYCHLORINATED BIPHENYL;

ARTICLE; ARTIFICIAL MILK; BIOACCUMULATION; BIRTH ORDER; BREAST FEEDING; BREAST MILK; CHILDBIRTH; CONTROLLED STUDY; FEMALE; FOOD CHAIN; FOOD CONTAMINATION; HUMAN; LIFESPAN; LIPID BLOOD LEVEL; MATERNAL AGE; PARITY; PERINATAL PERIOD; PREDICTION; PRENATAL EXPOSURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCTION;

ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MODELS, THEORETICAL; POLYCHLORINATED BIPHENYLS; PREGNANCY; REPRODUCTIVE BEHAVIOR;

EID: 79955865034     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002415     Document Type: Article

References (25)

1. Alcock RE, Sweetman AJ, Juan CY, Jones KC. 2000. A generic model of human lifetime exposure to persistent organic contaminants: development and application to PCB-101. Envion Pollut 110:253-265.
2. Aoki Y. 2001. Polychlorinated biphenyls, polychloronated dibenzo-p-dioxins, and polychlorinated dibenzofurans as endocrine disrupters-what we have learned from Yusho disease. Environ Res 86:2-11.
3. Bergonzi R, Specchia C, Dinolfo M, Tomasi C, De Palma G, Frusca T, et al. 2009. Distribution of persistent organochlorine pollutants in maternal and foetal tissues: data from an Italian polluted urban area. Chemosphere 76:747-754.
4. Breivik K, Czub G, McLachlan MS, Wania F. 2010. Towards an understanding of the link between environmental emissions and human body burdens of PCBs using CoZMoMAN. Environ Int 36:85-91.
5. Chen PH, Gaw JM, Wong CK, Chen CJ. 1980. Levels and gas chromatographic patterns of polychlorinated biphenyls in the blood of patients after PCB poisoning in Taiwan. Bull Environ Contam Toxicol 25:325-329.
6. Czub G, McLachlan MS. 2004. A food chain model to predict the levels of lipophilic organic contaminants in humans. Environ Toxicol Chem 23:2356-2366.
7. Dewailly É, Ayotte P, Laliberté C, Weber JP, Gingras S, Nantel AJ. 1996. Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) concentrations in the breast milk of women in Quebec. Am J Public Health 86:1241-1246.
8. Fujiwara K. 1975. Environmental and food contamination with PCB's in Japan. Sci Total Environ 4:219-247.
9. Guo YL, Hsu PC, Hsu CC, Lambert GH. 2000. Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 356:1240-1241.
10. Hsu PC, Huang W, Yao WJ, Wu MH, Guo YL, Lambert GH. 2003. Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans. JAMA 289:2943-2944.
11. Jacobson JL, Jacobson SW, Humphrey HEB. 1990. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr 116:38-45.
12. Lignell S, Aune M, Darnerud PO, Cnattingius S, Glynn A. 2009. Persistent organochlorine and organobromine compounds in mother's milk from Sweden 1996-2006: compound specific temporal trends. Environ Res 109:760-767.
13. Moser GA, McLachlan MS. 2002. Modeling digestive tract absorption and desorption of lipophilic organic contaminants in humans. Environ Sci Technol 36:3318-3325.
14. Ritter R, Scheringer M, MacLeod M, Schenker U, Hungerbuhler K. 2009. A multi-individual pharmacokinetic model framework for interpreting time trends of persistent chemicals in human populations: application to a postban situation. Environ Health Perspect 117:1280-1286.
15. Safe SH. 1994. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24:87-149.
16. Schade G, Heinzow B. 1998. Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: current extent of contamination, time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ 215:31-39.
17. Statistics Sweden. 2009. Summary of Population Statistics 1960-2008 (corrected version 2009-05-13). Available: http://www.scb.se/Pages/TableAndChart26041.aspx [accessed 22 February 2010].
18. Tajimi M, Watanabe M, Oki I, Ojima T, Nakamura Y. 2004. PCDDs, PCDFs and Co-PCBs in human breast milk samples collected in Tokyo, Japan. Acta Paediatr 93:1098-1102.
19. Toft G, Hagmar L, Giwercman A, Bonde JP. 2004. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod Toxicol 19:5-26.
20. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A, Lindh CH, et al. 2006. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 17:450-458.
21. Uemura H, Arisawa K, Hiyoshi M, Satoh H, Sumiyoshi Y, Morinaga K, et al. 2008. PCDDs/PCDFs and dioxin-like PCBs: recent body burden levels and their determinants among general inhabitants in Japan. Chemosphere 73:30-37.
22. Vaz R, Slorach SA, Hofvander Y. 1993. Organochlorine contaminants in Swedish human milk: studies conducted at the National Food Administration 1981-1990. Food Addit Contam 10:407-418.
23. Wang RY, Jain RB, Wolkin AF, Rubbin CH, Needham LL. 2009. Serum concentrations of selected persistent organic pollutants in a sample of pregnant females and changes in their concentrations during gestation. Environ Health Perspect 117:1244-1249.
24. Wania F, Breivik K, Persson NJ, McLachlan MS. 2006. CoZMo-POP 2-a fugacity-based dynamic multi-compartmental mass balance model of the fate of persistent organic pollutants. Environ Modell Softw 21:868-884.
25. Wigle DT, Arbuckle TE, Turner MC, Bérubé A, Yang QY, Liu SL, et al. 2008. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev 11:373-517.