Why cancer survivors have a lower risk of Alzheimer disease

Molecular Genetics and Metabolism

Volumn 107, Issue 3, 2012, Pages 630-631

  Thinnes, Friedrich P ^a  

^a NONE   (Germany)

Author keywords

ABC transporter; Anion channels; GxxxG; Multi drug resistance; P glycoprotein; Plasma lemma

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; AMYLOID A PROTEIN; AMYLOID PRECURSOR PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PORIN; VOLTAGE DEPENDENT ANION CHANNEL;

ALZHEIMER DISEASE; APOPTOSIS; BLOOD BRAIN BARRIER; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER SURVIVOR; CELL LINE; CELL TRANSFORMATION; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LETTER; NERVE CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RISK;

EID: 84867900782     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2012.06.016     Document Type: Letter

References (24)

1. Driver JA J.A., Beiser A., Au R., et al. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. BMJ 2012, 344:e1442.
2. Yamada M., Sasaki H., Mimori Y., et al. Prevalence and risks of dementia in the Japanese population: RERF's adult health study Hiroshima subjects. Radiation Effects Research Foundation. J. Am. Geriatr. Soc. 1999, 47:189-195.
3. Roe C.M., Behrens M.I., Xiong C., et al. Alzheimer disease and cancer. Neurology 2005, 64:895-898.
4. Roe C.M., Fitzpatrick A.L., Xiong C., et al. Cancer linked to Alzheimer disease but not vascular dementia. Neurology 2010, 74:106-112.
5. Thinnes F.P. Amyloid Aβ, cut from APP by β-secretase BACE1 and γ-secretase, induces apoptosis via opening type-1 porin/VDAC in cell membranes of hypometabolic cells-A basic model for the induction of apoptosis!?. Mol. Genet. Metab. 2010, 101:301-303.
6. Thinnes F.P. Apoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer's disease-a basic model of apoptosis?. Wien. Med. Wochenschr. 2011, 161:274-276.
7. Thinnes F.P. On GxxxG in N-terminal stretches of VDAC, critical in vertebrate apoptosis-missing in plants. Plant Mol. Biol. 2012, 79:1-3.
8. Thinnes F.P. To the knowledge of the (20)GYGFG(24) sequence stretch of type-1 VDAC: to understand why BCl-XL B4 domain peptides keep HeLa cells closed in hypotonic surroundings. Mol. Genet. Metab. 2012, 106:253-254.
9. Thinnes F.P. Alzheimer disease controls cancer - concerning the apoptogenic interaction of cell membrane-standing type-1 VDAC and amyloid peptides via GxxxG motifs 2012, Mol. Genet, Metab, [Electronic publication ahead of print].
10. Weller R.O., Massey A., Newman T.A., et al. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am. J. Pathol. 1998 Sep, 153(3):725-733.
11. Mechetner E., Kyshtoobayeva A., Zonis S., et al. Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to Taxol and doxorubicin. Clin. Cancer Res. 1998, 389:389-398.
12. Lam F.C., Liu R., Lu P., et al. Beta-amyloid efflux mediated by P-glycoprotein. J. Neurochem. 2001, 76:1121-1128.
13. Vogelgesang S., Warzok R.W., Cascorbi I., et al. The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 2004 May, 1(2):121-125.
14. Cirrito J.R., Deane R., Fagan A.M., et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model. J. Clin. Invest. 2005, 115:3285-3290.
15. Pahnke J., Wolkenhauer O., Krohn M., et al. Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 2008, 5:396-405.
16. Ueno M. Mechanisms of the penetration of blood-borne substances into the brain. Curr. Neuropharmacol. 2009, 7:142-149.
17. Hartz A.M.S., Miller D.S., Bauer B. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-β in a mouse model of Alzheimer's disease. Mol. Pharmacol. 2010, 77:715-723.
18. Abuznait A.H., Cain C., Burk I.D., et al. Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease. J. Pharm. Pharmacol. 2011, 63:1111-1118.
19. Luoma P.V. Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia. Curr. Mol. Med. 2011, 11:391-400. (Review).
20. Deane R., Wu Z., Zlokovic B.V. RAGE (yin) versus LRP (yang) balance regulates Alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 2004, 35(Suppl. 1):2628-2631.
21. Bartels A.L., Willemsen A.T., Kortekaas R., et al. Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. J. Neural Transm. 2008, 115:1001-1009.
22. Wolf A., Bauer B., Hartz A.M., et al. ABC transporters and the Alzheimer's disease enigma. Front. Psychiatry 2012, 3:1-14.
23. Wilcox C.K., Pitt J., Sebollela A., et al. Biological targeting and activity of pre-fibrillar Ab assemblies. Non-fi brillar Amyloidogenic Protein Assemblies-Common Cytotoxins Underlying Degenerative Diseases 2012, 113-133. Chapter 4, © Springer Science+Business Media B.V. 10.1007/978-94-007-2774-8_4. F. Rahimi, G. Bitan (Eds.).
24. Akanda N., Tofighi R., Brask J., et al. Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells. Cell Cycle 2008, 7:3225-3234.