Fatty liver and anti-oxidant enzyme activities along with peroxisome proliferator-activated receptors γ and α expressions in the liver of Wilson's disease

Molecular Genetics and Metabolism

Volumn 107, Issue 3, 2012, Pages 542-547

  Nagasaka, Hironori ^a   Miida, Takashi ^b   Inui, Ayano ^c   Inoue, Ikuo ^d   Tsukahara, Hirokazu ^e   Komatsu, Haruki ^c   Hiejima, Eitaro ^c   Fujisawa, Tomoo ^c   Yorifuji, Tohru ^f   Hiranao, Ken ichi ^g   Okajima, Hideaki ^h   Inomata, Yukihiro ⁱ  

^a TAKARAZUKA CITY HOSPITAL   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c SAISEIKAI YOKOHAMASHI TOBU HOSPITAL   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e OKAYAMA UNIVERSITY   (Japan)

^f OSAKA CITY GENERAL HOSPITAL   (Japan)

^g OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

ⁱ KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Catalase; Peroxisome proliferator activated receptors; Steatosis; Superoxide dismutase; Wilson's disease

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE CARRIER; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; FATTY LIVER; FEMALE; FULMINANT HEPATIC FAILURE; HUMAN; HUMAN TISSUE; LIVER INJURY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; STATISTICAL SIGNIFICANCE; TISSUE SECTION; WILSON DISEASE;

ADENOSINE TRIPHOSPHATASES; ADOLESCENT; ADULT; ASYMPTOMATIC DISEASES; CATALASE; CATION TRANSPORT PROTEINS; CHILD; CHILD, PRESCHOOL; COPPER; FATTY LIVER; FEMALE; GENE EXPRESSION; HEPATOLENTICULAR DEGENERATION; HUMANS; ISOENZYMES; LIVER; MALE; MUTATION; PPAR ALPHA; PPAR GAMMA; SEVERITY OF ILLNESS INDEX; SUPEROXIDE DISMUTASE;

EID: 84867900095     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2012.08.004     Document Type: Article

References (29)

1. Tanzi R.E., Petrukhin K., Chernov I., Pellequer J.L., Wasco W., Rass B., Romano D.M., Parano E., Pavone L., Brzustowicz L.M. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene. Nat. Genet. 1993, 5:344-350.
2. Scheinberg I.H., Sternlieb I. Wilson disease. Major problems in internal medicine 1984, 1-179. Saunders, Philadelphia. L.H. Smith (Ed.).
3. Sokol R.J., Narkewicz M.R. Copper and iron disorders. Liver Disease in Children 2001, 595-640. Lippincott Williams & Wilkins Co., Philadelphia. F.J. Suchy, R.J. Sokol, W.F. Balistreli (Eds.).
4. Anderson P.J., Popper H. Change in hepatic structure in Wilson's disease. Am. J. Pathol. 2001, 36:483-497.
5. Berman D.H., Leventhal R.I., Gavaler J.S., Cadoff E.M., Van Thiel D.H. Clinical differentiation of fulminant Wilsonian hepatitis from other causes of hepatic failure. Gastroenterology 1991, 100:1129-1134.
6. Schilsky M.L., Scheinberg I.H., Sternlieb I. Prognosis of Wilsonian chronic active hepatitis. Gastroenterology 1991, 100:762-767.
7. Aust S.D., Morehouse L.A., Thomas C.E. Role of metal in oxygen radical reactions. Free Radic. Biol. Med. 1985, 1:3-25.
8. Hochstein P., Kumar K.S., Forman S.J. Lipid peroxidation and the cytotoxicity of copper. Ann. N. Y. Acad. Sci. 1980, 355:240-248.
9. Sokol R.J., Twedt D., McKim J.M., Devereaux M.W., Karrer F.M., Kam I., von Steigman G., Narkewicz M.R., Bacon B.R., Britton R.S. Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 1994, 107:1788-1798.
10. Jimenez I., Aracena P., Letelier M.E., Navarro P., Speisky H. Chronic exposure of HepG2 cells to excess copper results in depletion of glutathione and induction of metallothionein. Toxicol. in Vitro 2002, 16:167-175.
11. Perlemuter G., Davit-Spraul A., Cosson C., Conti M., Bigorgne A., Paradis V., Corre M.P., Prat L., Kuoch V., Basdevant A., Pelletier G., Oppert J.M., Buffet C. Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease. Liver Int. 2005, 25:946-953.
12. Summer K.H., Eisenburg J. Low content of hepatic reduced glutathione in patients with Wilson's disease. Biochem. Med. 1985, 34:107-111.
13. Ogihara H., Ogiara T., Miki M., Yasuda H., Mino M. Plasma copper and antioxidant status in Wilson's disease. Pediatr. Res. 1995, 37:219-226.
14. von Herbay A., de Groot H., Hegi U., Stremmel W., Strohmeyer G., Sies H. Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease. J. Hepatol. 1994, 20:41-46.
15. Tailleux A., Wouters K., Staels B. Roles of PPARs in NAFLD: potential therapeutic targets. Biochim. Biophys. Acta 2012, 1821:809-818.
16. Morán-Salvador E., López-Parra M., García-Alonso V., Titos E., Martínez-Clemente M., González-Périz A., López-Vicario C., Barak Y., Arroyo V., Clària J. Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J. 2011, 25:2538-2550.
17. Abdelmegeed M.A., Yoo S.H., Henderson L.E., Gonzalez F.J., Woodcroft K.J., Song B.J. PPAR alpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J. Nutr. 2011, 141:603-610.
18. Aoyama T., Peters J.M., Iritani N., Nakajima T., Furihata K., Hashimoto T., Gonzalez F.J. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPAR alpha). J. Biol. Chem. 1998, 273:5678-5684.
19. Nagasawa T., Inada Y., Nakano S., Tamura T., Takahashi T., Maruyama K., Yamazaki Y., Kuroda J., Shibata N. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. Eur. J. Pharmacol. 2006, 536:182-191.
20. Vanden Berghe W., Vermeulen L., Delerive P., De Bosscher K., Staels B., Haegeman G. A paradigm for gene regulation: inflammation, NF-kappaB and PPAR. Adv. Exp. Med. Biol. 2003, 544:181-196.
21. Okiyama W., Tanaka N., Nakajima T., Tanaka E., Kiyosawa K., Gonzalez F.J., Aoyama T. Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. J. Hepatol. 2009, 50:1236-1246.
22. Lutchman G., Modi A., Kleiner D.E., Promrat K., Heller T., Ghany M., Borg B., Loomba R., Liang T.J., Premkumar A., Hoofnagle J.H. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology 2007, 46:424-429.
23. Inoue I., Noji S., Awata T., Takahashi K., Nakajima T., Sonoda M., Komoda T., Katayama S. Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor alpha is associated with Cu2+, Zn2+-superoxide dismutase in the liver. Life Sci. 1998, 63:135-144.
24. Bedossa P., Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996, 24:289-293.
25. McCord J.M., Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 1969, 244:6049-6055.
26. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
27. Lemoine M., Capeau J., Serfaty L. PPAR and liver injury in HIV-infected patients. PPAR Res. 2009, 2009:906167.
28. Yoneda M., Endo H., Nozaki Y., Tomimoto A., Fujisawa T., Fujita K., Yoneda K., Takahashi H., Saito S., Iwasaki T., Yamamoto S., Tsutsumi S., Aburatani H., Wada K., Hotta K., Nakajima A. Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. J. Pharmacol. Sci. 2007, 105:151-156.
29. Nagasaka H., Inoue I., Inui A., Komatsu H., Sogo T., Murayama K., Murakami T., Yorifuji T., Asayama K., Katayama S., Uemoto S., Kobayashi K., Takayanagi M., Fujisawa T., Tsukahara H. Relationship between oxidative stress and antioxidant systems in the liver of patients with Wilson disease: hepatic manifestation in Wilson disease as a consequence of augmented oxidative stress. Pediatr. Res. 2006, 60:472-427.