The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation

Food Chemistry

Volumn 136, Issue 3-4, 2013, Pages 1288-1295

  Daddaoua, Abdelali ^a   Martínez Plata, Enrique ^b   Ortega González, Mercedes ^c   Ocón, Borja ^c   Aranda, Carlos J ^c   Zarzuelo, Antonio ^c   Suárez, María D ^c   De Medina, Fermín Sánchez ^c   Martínez Augustin, Olga ^c  

^a CSIC   (Spain)

^b HOSPITAL DE PONIENTE   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

AHCC; Enterocyte; Macrophage immunomodulatory; NF B; TLR4

Indexed keywords

AHCC; CULTURE MEDIUM; ENTEROCYTE; INTESTINAL EPITHELIAL CELLS; MECHANISM OF ACTION; NUTRITIONAL SUPPLEMENTS; PROINFLAMMATORY CYTOKINES; SIGNAL TRANSDUCTION PATHWAYS; TLR4;

BODY FLUIDS; MACROPHAGES; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELL CULTURE;

ACTIVE HEXOSE CORRELATED COMPOUND; HEXOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CYTOKINE RELEASE; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOSTIMULATION; INTESTINE EPITHELIUM; MACROPHAGE; NONHUMAN; ONCOGENE; ONCOGENE ALPHA; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; DIETARY SUPPLEMENTS; EPITHELIAL CELLS; HUMANS; IMMUNOLOGIC FACTORS; INTESTINES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; POLYSACCHARIDES; RATS; TOLL-LIKE RECEPTOR 4;

EID: 84867899925     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.09.039     Document Type: Article

References (32)

1. S. Akira, and K. Takeda Functions of toll-like receptors: Lessons from KO mice Comptes Rendus Biologies 327 6 2004 581 589 (Pubitemid 38979508)
2. H. Aviles, T. Belay, M. Vance, B. Sun, and G. Sonnenfeld Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions Journal of Applied Physiology 97 4 2004 1437 1444 (Pubitemid 39299363)
3. S. Beinke, and S.C. Ley Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology The Biochemical Journal 382 Pt 2 2004 393 409 (Pubitemid 39243905)
4. C. Brikos, and L.A. O'Neill Signalling of toll-like receptors Handbook of Experimental Pharmacology 183 2008 21 50
5. A. Daddaoua, E. Martinez-Plata, R. Lopez-Posadas, J.M. Vieites, M. Gonzalez, P. Requena, A. Zarzuelo, M.D. Suarez, F.S. de Medina, and O. Martinez-Augustin Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis The Journal of Nutrition 137 5 2007 1222 1228 (Pubitemid 46701915)
6. R.A. Frost, G.J. Nystrom, and C.H. Lang Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 283 3 2002 R698 R709
7. Y. Gao, D. Zhang, B. Sun, H. Fujii, K. Kosuna, and Z. Yin Active hexose correlated compound enhances tumour surveillance through regulating both innate and adaptive immune responses Cancer Immunology, Immunotherapy 55 10 2006 1258 1266 (Pubitemid 43996648)
8. P.M. Kidd The use of mushroom glucans and proteoglycans in cancer treatment Alternative Medicine Review: A Journal of Clinical Therapeutic 5 1 2000 4 27 (Pubitemid 30132069)
9. A.A. Kuhl, H. Kakirman, M. Janotta, S. Dreher, P. Cremer, N.N. Pawlowski, C. Loddenkemper, M.M. Heimesaat, K. Grollich, M. Zeitz, S. Farkas, and J.C. Hoffmann Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils Gastroenterology 133 6 2007 1882 1892 (Pubitemid 350180801)
10. W.W. Lee, N. Lee, H. Fujii, and I. Kang Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1beta production from monocytes in humans Cellular Immunology 275 1-2 2012 19 23
11. R. Lopez-Posadas, I. Ballester, C. Mascaraque, M.D. Suarez, A. Zarzuelo, O. Martinez-Augustin, and F. Sanchez de Medina Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18) British Journal of Pharmacology 160 7 2010 1714 1726
12. Y. Matsui, J. Uhara, S. Satoi, M. Kaibori, H. Yamada, H. Kitade, A. Imamura, S. Takai, Y. Kawaguchi, A.H. Kwon, and Y. Kamiyama Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: A prospective cohort study Journal of Hepatology 37 1 2002 78 86 (Pubitemid 34713058)
13. K. Matsushita, Y. Kuramitsu, Y. Ohiro, M. Obara, M. Kobayashi, Y.Q. Li, and M. Hosokawa Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma Anti-Cancer Drugs 9 4 1998 343 350 (Pubitemid 28241824)
14. T. Miura, K. Kitadate, H. Nishioka, and K. Wakame Basic and clinical studies on Active Hexose Correlated Compound D. Bagchi, F.C. Lau, D.k. Ghosh, Biotechnology in functional foods and nutraceuticals vol. 1 2010 CRC Press, Taylor & Francis Group Boca Ratón, FL 51 60
15. G.J. Nau, J.F. Richmond, A. Schlesinger, E.G. Jennings, E.S. Lander, and R.A. Young Human macrophage activation programs induced by bacterial pathogens Proceedings of the National Academy of Sciences of the United States of America 99 3 2002 1503 1508 (Pubitemid 34136522)
16. A. Nenci, C. Becker, A. Wullaert, R. Gareus, G. van Loo, S. Danese, M. Huth, A. Nikolaev, C. Neufert, B. Madison, D. Gumucio, M.F. Neurath, and M. Pasparakis Epithelial NEMO links innate immunity to chronic intestinal inflammation Nature 446 7135 2007 557 561 (Pubitemid 46514732)
17. H. Nishioka, Y. Akao, and K. Wakame Potentiating action of AHCC on natural immunity Medical Science Digest 35 6 2009 2 6
18. B.W. Ritz Supplementation with active hexose correlated compound increases survival following infectious challenge in mice Nutrition Reviews 66 9 2008 526 531
19. B.W. Ritz, S. Nogusa, E.A. Ackerman, and E.M. Gardner Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection The Journal of Nutrition 136 11 2006 2868 2873 (Pubitemid 44771788)
20. S.K. Sainathan, E.M. Hanna, Q. Gong, K.S. Bishnupuri, Q. Luo, M. Colonna, F.V. White, E. Croze, C. Houchen, S. Anant, and B.K. Dieckgraefe Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis Inflammatory Bowel Diseases 14 1 2008 88 99 (Pubitemid 351196873)
21. S.K. Shah, P.A. Walker, S.D. Moore-Olufemi, A. Sundaresan, A.D. Kulkarni, and R.J. Andrassy An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in the surgical oncology patient JPEN. Journal of Parenteral and Enteral Nutrition 35 4 2011 449 458
22. T. Shea-Donohue, K. Thomas, M.J. Cody, Z. Aiping, L.J. Detolla, K.M. Kopydlowski, M. Fukata, S.A. Lira, and S.N. Vogel Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis Innate Immunity 14 2 2008 117 124
23. S. Shoham, C. Huang, J.M. Chen, D.T. Golenbock, and S.M. Levitz Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule Journal of Immunology 166 7 2001 4620 4626 (Pubitemid 32233748)
24. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, and D.C. Klenk Measurement of protein using bicinchoninic acid Analytical Biochemistry 150 1 1985 76 85 (Pubitemid 16258399)
25. Y. Sumiyoshi, K. Hashine, Y. Kakehi, K. Yoshimura, T. Satou, H. Kuruma, S. Namiki, and N. Shinohara Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: A phase II study Japanese Journal of Clinical Oncology 40 10 2010 967 972
26. J. Turner, and U. Chaudhary Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer Anti-Cancer Drugs 20 3 2009 215 216
27. M.J. van Vliet, H.J. Harmsen, E.S. de Bont, and W.J. Tissing The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis PLoS Pathogens 6 5 2010 e1000879
28. E. Voss, J. Wehkamp, K. Wehkamp, E.F. Stange, J.M. Schroder, and J. Harder NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2 Journal of Biological Chemistry 281 4 2006 2005 2011 (Pubitemid 43845788)
29. Y. Xu, N.H. Hunt, and S. Bao The role of granulocyte macrophage-colony- stimulating factor in acute intestinal inflammation Cell Research 18 12 2008 1220 1229
30. A. Yagita, S. Maruyama, S. Wakasugi, and Y. Sukegawa H-2 haplotype-dependent serum IL-12 production in tumour-bearing mice treated with various mycelial extracts In Vivo 16 1 2002 49 54 (Pubitemid 34436175)
31. S.F. Ye, K. Wakame, K. Ichimura, and S. Matsuzaki Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat Endocrine Regulations 38 1 2004 7 13 (Pubitemid 39060858)
32. Z. Yin, H. Fujii, and T. Walshe Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumour necrosis factor-alpha in healthy adults Human Immunology 71 12 2010 1187 1190