In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome

Developmental Biology

Volumn 372, Issue 1, 2012, Pages 55-67

  Pennimpede, Tracie ^a   Proske, Judith ^a   König, Andrea ^a   Vidigal, Joana A ^a   Morkel, Markus ^a,b   Bramsen, Jesper B ^a   Herrmann, Bernhard G ^a,b   Wittler, Lars ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Axial development; Brachyury; Caudal regression; Hypomorph; Mesoderm survival; Murine development; Notochord; RNAi knockdown; Urorectal malformations

Indexed keywords

MESSENGER RNA; MICRORNA; SHORT HAIRPIN RNA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DISEASE; BRACHYURY GENE; CAUDAL REGRESSION SYNDROME; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE FUNCTION; GENE SILENCING; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOSITY; HISTOLOGY; IN VIVO STUDY; MESODERM; MOUSE; NONHUMAN; NOTOCHORD; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECTUM DISEASE; SOMITE; URORECTAL MALFORMATION;

ANIMALIA; MURINAE;

EID: 84867896886     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2012.09.003     Document Type: Article

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