Pathogenesis of malaria revisited

Medical Microbiology and Immunology

Volumn 201, Issue 4, 2012, Pages 599-604

  Dasari, Prasad ^a   Bhakdi, Sucharit ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Coagulation; Complement; Digestive vacuole; Immunopathogenesis; Malaria

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BLOOD CLOTTING FACTOR 10A; COMPLEMENT; DEXTRAN SULFATE; HEMOGLOBIN; HEMOZOIN; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 1; MONOCLONAL ANTIBODY;

BACTERIAL INFECTION; BLOOD CLOTTING; CELL INVASION; CELL VACUOLE; COMPLEMENT ACTIVATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME ACTIVATION; HUMAN; MALARIA; MEROZOITE; NONHUMAN; OPSONIZATION; PARASITE DEVELOPMENT; PARASITE VIRULENCE; PATHOGENESIS; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; REVIEW;

ANIMALS; BLOOD COAGULATION; COMPLEMENT ACTIVATION; HUMANS; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; VACUOLES;

EID: 84867894098     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-012-0265-y     Document Type: Review

References (29)

1. Berendt AR, Tumer GD, Newbold CI (1994) Cerebral malaria: the sequestration hypothesis. Parasitol Today 10:412-414
2. Clark IA, Cowden WB (2003) The pathophysiology of falciparum malaria. Pharmacol Ther 99:221-260
3. Moxon CA, Heyderman RS, Wassmer SC (2009) Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol 166: 99-108
4. van der Heyde HC, Nolan J, Combes V, Gramaglia I, Grau GE (2006) A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends Parasitol 22:503-508
5. Francischetti IM, Seydel KB, Monteiro RQ (2008) Blood coagulation, inflammation, and malaria. Microcirculation 15:81-107
6. Neva FA, Howard WA, Glew RH, Krotoski WA, Gam AA, Collins WE, Atkinson JP, Frank MM (1974) Relationship of serum complement levels to events of the malarial paroxysm. J Clin Invest 54:451-460
7. Glew RH, Atkinson JP, Frank MM, Collins WE, Neva FA (1975) Serum complement and immunity in experimental simian malaria. I. Cyclical alterations in C4 related to schizont rupture. J Infect Dis 131:17-25
8. Helegbe GK, Goka BQ, Kurtzhals JA, Addae MM, Ollaga E, Tetteh JK, Dodoo D, Ofori MF, Obeng-Adjei G, Hirayama K, Awandare GA, Akanmori BD (2007) Complement activation in Ghanaian children with severe Plasmodium falciparum malaria. Malar J 6:165
9. Roestenberg M, McCall M, Mollnes TE, van Deuren M, Sprong T, Klasen I, Hermsen CC, Sauerwein RW, van der Ven A (2007) Complement activation in experimental human malaria infection. Trans R Soc Trop Med Hyg 101:643-649
10. Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC (2008) C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205:1133-1143
11. Ramos TN, Darley MM, Hu X, Billker O, Rayner JC, Ahras M, Wohler JE, Barnum SR (2011) Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. J Immunol 186:6657-6660
12. Dasari P, Heber SD, Beisele M, Torzewski M, Reifenberg K, Orning C, Fries A, Zapf A-L, Baumeister S, Lingelbach K, Udomsangpetch R, Bhakdi SC, Reiss K, Bhakdi S (2012) Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation. Blood 119:4301-4310
13. Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9:729-740
14. Dluzewski AR, Ling IT, Hopkins JM, Grainger M, Margos G, Mitchell GH, Holder AA, Bannister LH (2008) Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19)). PLoS ONE 3:e3085
15. Schwarzer E, Turrini F, Ulliers D, Giribaldi G, Ginsburg H, Arese P (1992) Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J Exp Med 176:1033-1041
16. Skorokhod OA, Alessio M, Mordmuller B, Arese P, Schwarzer E (2004) Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect. J Immunol 173:4066-4074
17. Giribaldi G, Prato M, Ulliers D, Gallo V, Schwarzer E, Akide- Ndunge OB, Valente E, Saviozzi S, Calogero RA, Arese P (2010) Involvement of inflammatory chemokines in survival of human monocytes fed with malarial pigment. Infect Immun 78:4912-4921
18. Pagola S, Stephens PW, Bohle DS, Kosar AD, Madsen SK (2000) The structure of malaria pigment beta-haematin. Nature 404: 307-310
19. Nguyen PH, Day N, Pram TD, Ferguson DJ, White NJ (1995) Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg 89:200-204
20. Dasari P, Reiss K, Lingelbach K, Baumeister S, Lucius R, Udomsangpetch R, Bhakdi SC, Bhakdi S (2011) Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes. Blood 118:4946-4956
21. Mabey DC, Brown A, Greenwood BM (1987) Plasmodium falciparum malaria and Salmonella infections in Gambian children. J Infect Dis 155:1319-1321
22. Bronzan RN, Taylor TE, Mwenechanya J, Tembo M, Kayira K, Bwanaisa L, Njobvu A, Kondowe W, Chalira C, Walsh AL, Phiri A, Wilson LK, Molyneux ME, Graham SM (2007) Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome. J Infect Dis 195:895-904
23. Agnandji ST, Lell B, Soulanoudjingar SS et al (2011) First results of phase 3 trial of RTS, S/AS01 malaria vaccine in African children. N Engl J Med 365:1863-1875
24. White NJ (2011) A vaccine for malaria. N Engl J Med 365: 1926-1927
25. Cheng XJ, Hayasaka H, Watanabe K, Tao YL, Liu JY, Tsukamoto H, Horii T, Tanabe K, Tachibana H (2007) Production of high-affinity human monoclonal antibody fab fragments to the -kilodalton C-terminal merozoite surface protein 1 of Plasmodium falciparum. Infect Immun 75:3614-3620
26. Lazarou M, Guevara Patino JA, Jennings RM, McIntosh RS, Shi J, Howell S, Cullen E, Jones T, Adame-Gallegos JR, Chappel JA, McBride JS, Blackman MJ, Holder AA, Pleass RJ (2009) Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies. Infect Immun 77:5659-5667
27. Stubbs J, Olugbile S, Saidou B, Simpore J, Corradin G, Lanzavecchia A (2011) Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allelespecific human antibodies. Infect Immun 79:1143-1152
28. van der Heyde HC, Elloso MM, vande Waa J, Schell K, Weidanz WP (1995) Use of hydroethidine and flow cytometry to assess the effects of leukocytes on the malarial parasite Plasmodium falciparum. Clin Diagn Lab Immunol 2:417-425
29. Kumaratilake LM, Ferrante A, Rzepczyk CM (1990) Tumor necrosis factor enhances neutrophil-mediated killing of Plasmodium falciparum. Infect Immun 58:788-793