Development of retinal pigment epithelium from human parthenogenetic embryonic stem cells and microRNA signature

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 9, 2012, Pages 5334-5343

  Li, Wen Bo ^a   Zhang, Yun Shan ^c   Lu, Zhen Yu ^b,c   Dong, Li Jie ^a   Wang, Fei E ^a   Dong, Rong ^b   Li, Xiao Rong ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tianjin Central Hospital for Obstetrics and Gynecology   (China)

^c Union Stem Cell and Gene Engineering Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 146A; TRANSCRIPTION FACTOR PAX6; CTNNBIP1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MICROARRAY ANALYSIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VISUAL IMPAIRMENT; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; DOWN REGULATION; GENETICS; METABOLISM; PARTHENOGENESIS; PHYSIOLOGY; UPREGULATION;

CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; EMBRYONIC STEM CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICRORNAS; PARTHENOGENESIS; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RETINAL PIGMENT EPITHELIUM; UP-REGULATION;

EID: 84867878612     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-8303     Document Type: Article

References (38)

1. Nussenblatt RB, Ferris F 3rd. Age-related macular degeneration and the immune response: implications for therapy. Am J Ophthalmol. 2007;44:618-626.
2. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85:845-881.
3. Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Agerelated macular degeneration-emerging pathogenetic and therapeutic concepts. Ann Med. 2006;38:450-471.
4. Idelson M, Alper R, Obolensky A, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell. 2009;5:396-408.
5. Klimanska I, Hipp J, Rezai KA, West M, Atala A, Lanza R. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells. 2004;6:217-245.
6. Osakada F, Ikeda H, Sasa Y, Takahashi M. Stepwise differentiation of pluripotent stem cells into retinal cells. Nature Protocols. 2009;4:811-824.
7. Carr AJ, Vugler A, Lawrence J, et al. Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay. Mol Vis. 2009;15:283-295.
8. Haruta M, Sasai Y, Kawasaki H, et al. In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. Invest Ophthalmol Vis Sci. 2004;45:1020-1025.
9. Lu B, Malcuit C, Wang S, et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells. 2009;27:2126-2135.
10. Lund RD, Wang S, Klimanskaya I, et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells. 2006;8:189-199.
11. Vugler A, Carr AJ, Lawrence J, et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp Neurol. 2008;214: 347-361.
12. Schwartz SD, Hubschman JP, Heilwell G, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012;379:713-720.
13. Kim K, Ng K, Rugg-Gunn PJ, et al. Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell. 2007;1:346-352.
14. Mai Q, Yu Y, Li T, et al. Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res. 2007;17: 1008-1019.
15. Revazova ES, Turovets NA, Kochetkova OD, et al. Patientspecific stem cell lines derived from human parthenogenetic blastocysts. Cloning Stem Cells. 2007;9:432-449.
16. Dighe V, Clepper L, Pedersen D, et al. Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes. Stem Cells. 2008;26:756-766.
17. Harness JV, Turovets NA, Seiler MJ, et al. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One. 2011;6:e14499.
18. Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010;7:36-41.
19. Laurent LC. MicroRNAs in embryonic stem cells and early embryonic development. J Cell Mol Med. 2008;12:2181-2188.
20. Lu Z, Zhu W, Yu Y, et al. Derivation and long-term culture of human parthenogenetic embryonic stem cells using human foreskin feeders. J Assist Reprod Genet. 2010;27:285-291.
21. Maminishkis A, Chen S, et al. Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest Ophthalmol Vis Sci. 2006;47:3612-3624.
22. Wang FE, Zhang C, Maminishkis A, et al. MicroRNA-204/211 alters epithelial physiology. FASEB J. 2010;24:1552-1571.
23. Taylor CJ, Bolton EM, Pocock S, Sharples LD, Pedersen RA, Bradley JA. Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet. 2005;366:2019-2025.
24. Labbé JC, Capony JP, Caput D, et al. MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J. 1989; 8:3053-3058.
25. Li C, Chen Z, Liu Z, et al. Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells. Hum Mol Genet. 2009;18: 2177-2187.
26. Liao JL, Yu J, Huang K, et al. Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet. 2010;19:4229-4238.
27. Kapsimali M, Kloosterman WP, de Bruijn E, Rosa F, Plasterk RH, Wilson SW. MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol. 2007;8:R173.
28. Ryan DG, Oliveira-Fernandes M, Lavker RM. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity. Mol Vis. 2006;12:1175-1184.
29. Karali, M, Peluso I, Marigo V, Banfi S. Identification and characterization of microRNAs expressed in the mouse eye. Invest Ophthalmol Vis Sci. 2007;48:509-515.
30. Conte I, Carrellaa S, Avellinoa R, et al. miR-204 is required for lens and retinal development via Meis2 targeting. PNAS. 2010; 107:15491-15496.
31. Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z. Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol. 2009;334:31-45.
32. Suh MR, Lee Y, Kim JY, et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol. 2004;270:488-498.
33. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev. 2009;18:749-758.
34. Stadler B, Ivanovska I, Mehta K, et al. Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev. 2010;19:935-950.
35. Lin SL Chang DC, Lin CH, Ying SY, Leu D, Wu DTS. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res. 2011;39:1054-1065.
36. Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J. 2011;25:1497-1508.
37. Lee KL, Lim SK, Orlov YL, et al. Graded Nodal/Activin signaling titrates conversion of quantitative phospho-smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet. 2011;7:e1002130.
38. Pucéat M. TGFβ in the differentiation of embryonic stem cells. Cardiovasc Res. 2007;74:256-261.