Targeting ILK and β4 integrin abrogates the invasive potential of ovarian cancer

Biochemical and Biophysical Research Communications

Volumn 427, Issue 3, 2012, Pages 642-648

  Choi, Yoon Pyo ^a   Kim, Baek Gil ^a   Gao, Ming Qing ^a   Kang, Suki ^a   Cho, Nam Hoon ^a  

^a Yonsei University   (South Korea)

Author keywords

4 Integrin; Combined effect; ILK (integrin linked kinase); Invasiveness; Ovarian cancer

Indexed keywords

BETA1 INTEGRIN; BETA4 INTEGRIN; CASPASE 3; GELATINASE A; GELATINASE B; INTEGRIN LINKED KINASE; PROTEIN KINASE B; RAC1 PROTEIN; SHORT HAIRPIN RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INVASION; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE TARGETING; GENES, TUMOR SUPPRESSOR; HUMANS; INTEGRIN BETA4; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING;

EID: 84867875608     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.114     Document Type: Article

References (17)

1. Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 1996, 379:91-96.
2. Dedhar S., Williams B., Hannigan G. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signaling. Trends Cell Biol. 1999, 9:319-923.
3. Tu Y., Li F., Goicoechea S., et al. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol. Cell. Biol. 1999, 19:2425-2434.
4. Li F., Zhang Y., Wu C. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. Mol. Cell. Biol. 1999, 112:4589-4599.
5. Chiswell B.P., Zhang R., Murphy J.W., et al. The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. USA 2008, 105:20677-20682.
6. Wickström S.A., Lange A., Montanez E., et al. The ILK/PINCH/parvin complex: the kinase is dead long live the pseudokinase!. EMBO J. 2010, 29:281-291.
7. Wu C., Dedhar S. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J. Cell Biol. 2001, 155:505-510.
8. Persad S., Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev. 2003, 22:375-384.
9. Hannigan G., Troussard A.A., Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat. Rev. Cancer 2005, 5:51-63.
10. McDonald P.C., Fielding A.B., Dedhar S. Integrin-linked kinase-essential roles in physiology and cancer biology. J. Cell Sci. 2008, 121:3121-3132.
11. Ahmed N., Riley C., Oliva K., et al. Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J. Pathol. 2003, 201:229-237.
12. Ahmed N., Oliva K., Rice G.E., et al. Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma. Clin. Cancer Res. 2004, 10:2415-2420.
13. Qian Y., Zhong X., Flynn D.C., et al. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 2005, 24:3154-3165.
14. Lessan K., Aguiar D.J., Oegema T., et al. CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. Am. J. Pathol. 1999, 154:1525-1537.
15. Wang E., Ngalame Y., Panelli M.C., et al. Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. Clin. Cancer Res. 2005, 11:113-122.
16. Landen C.N., Kim T.J., Lin Y.G., et al. Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer. Neoplasia 2008, 10:1259-1267.
17. Skubitz A.P., Bast R.C., Wayner E.A., et al. Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am. J. Pathol. 1996, 148:1445-1461.