A spread containing bioactive milk peptides Ile-Pro-Pro and Val-Pro-Pro, and plant sterols has antihypertensive and cholesterol-lowering effects

Food and Function

Volumn 3, Issue 6, 2012, Pages 621-627

  Turpeinen, Anu M ^a   Ikonen, Mikko ^a   Kivimäki, Anne S ^b   Kautiainen, Hannu ^c   Vapaatalo, Heikki ^b   Korpela, Riitta ^b  

^a VALIO LTD   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Finland MedCare Ltd   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIO-VASCULAR DISEASE; CARDIO-VASCULAR RISK FACTORS; CHOLESTEROL-LOWERING EFFECTS; DIASTOLIC PRESSURE; HYPERCHOLESTEROLEMIA; INTERVENTION PERIOD; PRIMARY TREATMENT; SYSTOLIC BLOOD PRESSURE;

ALCOHOLS; BLOOD PRESSURE; BODY FLUIDS; CHOLESTEROL; COMPENSATION (PERSONNEL); GLUCOSE; PATHOLOGY; PEPTIDES;

LIPIDS;

ANTIHYPERTENSIVE AGENT; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MARGARINE; PEPTIDE; PHYTOSTEROL;

ADULT; AGED; ANIMAL; ARTICLE; BLOOD PRESSURE; CATTLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET THERAPY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FERMENTATION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; LACTOBACILLUS HELVETICUS; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MILK; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIHYPERTENSIVE AGENTS; BLOOD GLUCOSE; BLOOD PRESSURE; CATTLE; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; FEMALE; FERMENTATION; HUMANS; HYPERCHOLESTEROLEMIA; HYPERTENSION; LACTOBACILLUS HELVETICUS; MALE; MARGARINE; MIDDLE AGED; MILK; PEPTIDES; PHYTOSTEROLS;

EID: 84867863700     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c2fo10286b     Document Type: Article

References (38)

1. T. A. Gaziano, Cardiovascular disease in the developing world and its cost effective management, Circulation, 2005, 112, 3546-3553.
2. G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A. M. Heagerty, S. E. Kjeldsen, S. Laurent, K. Narkiewicz, L. Ruilope, A. Rynkiewicz, R. E. Schmieder, H. A. Boudier and A. Zanchetti, ESH-ESC Task force on the management of arterial hypertension: ESH-ESC practice guidelines for the management of arterial hypertension, J. Hyperlens., 2007, 25, 1751-1762.
3. L. J. Appel, American Society of Hypertension writing group. ASH position paper: dietary approaches to lower blood pressure, J. Clin. Hypertens., 2009, 11, 358-368.
4. A. L. Catapano, Z. Reiner, G. De Backer, I. Graham, M. R. Taskinen, O. Wiklund, S. Agewall, E. Alegria, M. J. Chapman, P. Durrington, S. Erdine, J. Halcox, R. Hobbs, J. Kjekshus, P. P. Filardi, G. Riccardi, R. F. Storey and D. Wood, ESC/EAS Guidelines for the management of dyslipidaemias. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS), Atherosclerosis, 2011, 217, S1-S44.
5. J.-Y. Xu, L.-Q. Qin, P.-Y. Wang, W. Li and C. Chang, Effects of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials, Nutrition, 2008, 24, 933-940.
6. A. H. Pripp, Effect of peptides derived from food proteins on blood pressure: a meta-analysis of randomized controlled trials. Food Nutr Res, 2008, DOI: 10.3402/fnr.v2510.1641.
7. A. F. G. Cicero, B. Gerocarni, L. Laghi and C. Borghi, Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials, J Hum Hyperlens, 2010, 25, 1-12.
8. P. Jäkälä and H. Vapaatalo, Antihypertensive peptides from milk proteins, Pharmaceuticals, 2010, 3, 251-272.
9. A. M. Turpeinen, P. Ehlers, A. S. Kivimäki, S. Järvenpä ä, I. Filler, E. Wiegert, E. Jähnchen, H. Vapaatalo, R. Korpela and F. Wagner, Ile-Pro-Pro and Val-Pro-Pro tripeptide-containing milk product has acute blood pressure lowering effects in mildly hypertensive subjects, Clin. Exp. Hypertens., 2011, 33(6), 388-396.
10. L. Seppo, T. Jauhiainen, T. Poussa and R. Korpela, A fermented milk high in bioactive peptides has a blood pressure lowering effect in hypertensive subjects, Am J Clin Nutr, 2003, 77, 326-330.
11. K. C. Sung, J. Y. Suh, B. S. Kim, J. H. Kang, H. Kim, M. H. Lee, J. R. Park and S. W. Kim, High sensitivity C-reactive protein as an independent risk factor for essential hypertension, Am. J-Hypertens., 2003, 16, 429-433.
12. G J. Blake, N. Rifai, J. E. Buring and P. M. Ridker, Blood pressure, C reactive protein, and risk of future cardiovascular events, Circulation, 2003, 108, 2993-2939.
13. K. Y. Stokes, D. Cooper, A. Tailor and D. N. Granger, Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide, Free Radical Biol Med., 2002, 33, 1026-1036.
14. T. Ueland, M. N. Vissers, A. Wiegman, J. Rodenburg, B. Hutten, L. Gullestad, L. Ose, N. Rifai, P. M. Ridker, J. J. P. Kastelein, P. Aukrust and A. G. Semb, Increased inflammatory markers in children with familial hypercholesterolaemia, Eur. J. Clin. Invest., 2006, 36, 147-152.
15. C. Chrysohoou, C. Pitsavos, D. B. Panagiotakos, J. Skoumas and C. Stefanadis, Association between prehypertension status and inflammatory markers related to atherosclerotic disease: The ATTICA Study, Am. J. Hypertens., 2004, 17, 568-573.
16. D. E. King, B. M. Egan, A. G Mainous and M. E. Geesey, Elevation of Creactive protein in people with prehypertension, J. Clin. Hypertens., 2004, 6, 562-568.
17. P. Ferroni, F. Martini, C. M. Cardarello, P. P. Gazzaniga, G. Davi and S. Basili, Enhanced IL-1α in Hypercholesterolemia. Effect of simvastatin and low dose aspirin, Circulation, 2003, 108, 1673-1675.
18. B. Schieffer, C. Bünte, J. Witte, K. Hoeper, R. H. Böger, E. Schwedhelm and H. Drexler, Comparative effects of ATI-antagonism and angiotensinconverting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease, J. Am. Coll. Cardiol., 2004, 44, 362-368.
19. S. S. AbuMweis, R. Barake and P. J. H. Jones, Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomised controlled trials, Food Nutr. Res., 2008, DOI: 10.3402/fnr.v5210.1811.
20. I. Demonty, R. T. Ras, H. C. M. van der Knaap, G. S. Duchateau, L. Meijer, P. L. Zock, J. M. Geleijnse and E. A. Trautwein, Continuous dose-response relationship of the LDL cholesterol-lowering effect of phytosterol intake, J Nutr, 2009, 139, 271-284.
21. N. De Jong, A. Zuur, M. C. Wolfs, G. C. Wendel-Vos, J. M. van Raaij and A. J. Schuit, Exposure and effectiveness of phytosterol/stanol-enriched margarines, Eur. J. Clin. Nutr., 2007, 61, 1407-1415.
22. E. A. Trautwein, G. S. Duchateau, Y. G. Lin, S. M. Melnikov, H. O. Fw. Molhuizen and F. Y. Ntanios, Proposed mechanism of cholesterol-lowering action of plant sterols, Eur. J. Lipid Sci. Technol, 2003, 105, 171-185.
23. W. T. Friedewald, R. I. Levy and D. S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, 1972, 18, 499-502.
24. L. Seppo, O. Kerojoki, T. Suomalainen and R. Korpela, The effects of a Lactobacillus helveticus LBK-16H fermented milk on hypertension - a pilot study in humans. Milk Sci Int, 2002, 57, 124-127.
25. T. Jauhiainen, H. Vapaatalo, T. Poussa, S. Kyrönpalo, M. Rasmussen and R. Korpela, Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement, Am. J. Hypertens., 2005, 18, 1600-1605.
26. A. M. Turpeinen, M. Kumpu, M. Rönnback, L. Seppo, H. Kautiainen, T. Jauhiainen, H. Vapaatalo and R. Korpela, Antihypertensive and cholesterol-lowering effects of a spread containing bioactive peptides IPP and VPP and plant sterols, J. Fund. Foods, 2009, 1, 260-265.
27. T. Jauhiainen, M. Rönnback, H. Vapaatalo, K. Wuolle, H. Kautiainen, P.-H. Groop and R. Korpela, Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects, Eur. J. Clin. Nutr., 2010, 64, 424-431.
28. T. J. Niiranen, I. M. Kantola, R. Vesalainen, J. Johansson and M. J. Ruuska, A comparison of home measurement and ambulatory monitoring of blood pressure in the adjustment of antihypertensive treatment, Am. J. Hypertens., 2006, 19, 468-474.
29. M. R. Hänninen, T. J. Niiranen, P. J. Puukka and A. M. Jula, Comparison of home and ambulatory blood pressure measurement in the diagnosis of masked hypertension, J. Hypertens., 2010, 28, 709-714.
30. T. J. Niiranen, A. M. Jula, I. M. Kantola, H. Karanko and A. Reunanen, Home-measured blood pressure is more strongly associated with electrocardiographic left ventricular hypertrophy than is clinic blood pressure: the Finn-HOME Study, J. Hum. Hypertens., 2007, 21, 788-794.
31. J. Tuomilehto, J. Lindström, J. Hyyrynen, R. Korpela, M.-L. Karhunen, L. Mikkola, T. Jauhiainen, L. Seppo and A. Nissinen, Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension, J. Hum. Hypertens., 2004, 18, 795-802.
32. D. J. Jenkins, C. W. Kendall, A. Marchie, D. A. Faulkner, J. M. Wong, R. de Souza, A. Emam, T. L. Parker, E. Vidgen, K. G. Lapsley, E. A. Trautwein, R. G. Josse, L. A. Leiter and P. W. Connelly, Effects of a dietary portfolio of cholesterol-lowering foods versus lovastatin on serum lipids and C-reactive protein, JAMA, J. Am. Med. Assoc, 2003, 290, 502-510.
33. D. J. Jenkins, C. W. Kendall, A. Marchie, D. A. Faulkner, A. R. Josse, J. M. Wong, R. de Souza, A. Emam, T. L. Parker, T. J. Li, R. G. Josse, L. A. Leiter, W. Singer and P. W. Connelly, Direct comparison of dietary portfolio versus statin on C-reactive protein, Eur. J. Clin. Nutr., 2005, 59, 851-860.
34. S. Devaraj, B. C. Autret and I. Jialal, Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunters, Am J Clin Nutr, 2006, 84, 756-761.
35. P. M. Clifton, M. Mano, G. S. Duchateau, H. C. van der Knaap and E. A. Trautwein, Dose-response effect of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols, Eur. J. Clin. Nutr., 2008, 62, 968-977.
36. M. A. Micallef and M. L. Garg, Anti-inflammatory and cardioprotective effects of n-3 fatty acids and plant sterols in hyperlipidemic individuals, Atherosclerosis, 2009, 204, 476-482.
37. R. A. Othman and M. H. Moghadasian, Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of antiinflammatory properties, Nutr. Rev., 2011, 69, 371-382.
38. P. I. Ehlers, A. S. Kivimäki, A. M. Turpeinen, R. Korpela and H. Vapaatalo, High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension, Br. J. Nutr., 2011, 106, 1353-1363.