Prediabetic obese adolescents have a more atherogenic lipoprotein profile compared with normoglycemic obese peers

Journal of Pediatrics

Volumn 161, Issue 5, 2012, Pages 881-886

  Magge, Sheela N ^a,c   Prasad, Divya ^a   Koren, Dorit ^a,c   Gallagher, Paul R ^a   Mohler III, Emile R ^b,c   Stettler, Nicolas ^a,c   Levitt Katz, Lorraine E ^a,c   Rader, Daniel J ^b,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

BMI; Body mass index; Cardiovascular disease; CHOP; CVD; HDL C; HDL P; High density lipoprotein cholesterol; High density lipoprotein particles; HOMA IR; Homeostasis Model Assessment Insulin Resistance Index; IFG; IGT; Impaired fasting glucose; Impaired glucose tolerance; LDL C; LDL P; Low density lipoprotein cholesterol; Low density lipoprotein particles; NMR; Nuclear magnetic resonance; The Children's Hospital of Philadelphia; Very low density lipoprotein particles; VLDL P

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL GLUCOSE TOLERANCE TEST; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCHOOL CHILD;

ADOLESCENT; ATHEROSCLEROSIS; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALE; OBESITY; PREDIABETIC STATE; REGRESSION ANALYSIS;

EID: 84867856758     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2012.04.006     Document Type: Article

References (16)

1. A. Juutilainen, S. Lehto, T. Ronnemaa, K. Pyorala, and M. Laakso Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects Diabetes Care 28 2005 2901 2907
2. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 33 Suppl 1 2010 S62 S69
3. J.E. Gerich The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity Endocr Rev 19 1998 491 503
4. G.C. Weir Non-insulin-dependent diabetes mellitus: interplay between B-cell inadequacy and insulin resistance Am J Med 73 1982 461 464
5. H.S. Kang, B. Gutin, P. Barbeau, M.S. Litaker, J. Allison, and N.A. Le Low-density lipoprotein particle size, central obesity, cardiovascular fitness, and insulin resistance syndrome markers in obese youths Int J Obes Relat Metab Disord 26 2002 1030 1035
6. D.C. Goff Jr., R.B. D'Agostino Jr., S.M. Haffner, and J.D. Otvos Insulin resistance and adiposity influence lipoprotein size and subclass concentrations. Results from the Insulin Resistance Atherosclerosis Study Metabolism 54 2005 264 270
7. S.F. Burns, S. Lee, and S.A. Arslanian In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children Diabetes Care 32 2009 2087 2093
8. A. Festa, K. Williams, A.J. Hanley, J.D. Otvos, D.C. Goff, and L.E. Wagenknecht Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study Circulation 111 2005 3465 3472
9. C.L. Ogden, R.J. Kuczmarski, K.M. Flegal, Z. Mei, S. Guo, and R. Wei Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version Pediatrics 109 2002 45 60
10. C.D. Gardner, S.P. Fortmann, and R.M. Krauss Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women JAMA 276 1996 875 881
11. E.L. Barr, P.Z. Zimmet, T.A. Welborn, D. Jolley, D.J. Magliano, and D.W. Dunstan Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab) Circulation 116 2007 151 157
12. C. Li, E.S. Ford, G. Zhao, and A.H. Mokdad Prevalence of prediabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005-2006 Diabetes Care 32 2009 342 347
13. E. D'Adamo, V. Northrup, R. Weiss, N. Santoro, B. Pierpont, and M. Savoye Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intra-abdominal fat accretion Am J Clin Nutr 92 2010 500 508
14. A. Moran, D.R. Jacobs Jr., J. Steinberger, C.P. Hong, R. Prineas, and R. Luepker Insulin resistance during puberty: results from clamp studies in 357 children Diabetes 48 1999 2039 2044
15. S.N. Magge, N. Stettler, D. Koren, L.E. Levitt Katz, P.R. Gallagher, and E.R. Mohler III Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents J Clin Endocrinol Metab 96 2011 1549 1554
16. C. Meyer, W. Pimenta, H.J. Woerle, T. Van Haeften, E. Szoke, and A. Mitrakou Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans Diabetes Care 29 2006 1909 1914