Impact of multiple antigenic epitopes from ApoB100, hHSP60 and Chlamydophila pneumoniae on atherosclerotic lesion development in Apobtm2SgyLdlrtm1Her J mice

Atherosclerosis

Volumn 225, Issue 1, 2012, Pages 56-68

  Lu, Xinjie ^a   Xia, Min ^a   Endresz, Valeria ^b   Faludi, Ildiko ^b   Szabo, Andrea ^c   Gonczol, Eva ^d   Mundkur, Lakshmi ^e   Chen, Daxin ^a,f   Kakkar, Vijay ^a,e  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d NATIONAL CENTER FOR EPIDEMIOLOGY   (Hungary)

^e THROMBOSIS RESEARCH INSTITUTE   (India)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ApoB 100; Atherosclerosis; C. pneumoniae; HHSP60; Immunization

Indexed keywords

ANTIBODY; APOLIPOPROTEIN B; APOLIPOPROTEIN B100; CHAPERONIN 60; CHEMOKINE; CYTOKINE; EPITOPE; LOW DENSITY LIPOPROTEIN RECEPTOR; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CELL INFILTRATION; CELLULAR IMMUNITY; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SERUM; SPLEEN CELL;

ANIMALS; ANTIGENS, BACTERIAL; APOLIPOPROTEIN B-100; CHAPERONIN 60; CHLAMYDOPHILA PNEUMONIAE; ELAPID VENOMS; EPITOPES; HUMANS; IMMUNIZATION; MALE; MICE; PEPTIDE FRAGMENTS; PLAQUE, ATHEROSCLEROTIC; RECOMBINANT PROTEINS; T-LYMPHOCYTES, REGULATORY;

EID: 84867849842     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.07.021     Document Type: Article

References (33)

1. Lu X., Chen D., Endresz V., et al. Immunization with a combination of ApoB and hHSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice. Atherosclerosis 2010, 212:472-480.
2. Zernecke A., Weber C. Chemokines in the vascular inflammatory response of atherosclerosis. Cardiovasc Res 2010, 86:192-201.
3. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
4. Chyu K.Y., Nilsson J., Shah P.K. Immunization for atherosclerosis. Curr Atheroscler Rep 2007, 9:104-109.
5. Grundtman C., Wick G. The autoimmune concept of atherosclerosis. Curr Opin Lipidol 2011, 22:327-334.
6. Gordon S., Clarke S., Greaves D., Doyle A. Molecular immunobiology of macrophages: recent progress. Curr Opin Immunol 1995, 7:24-33.
7. Schiopu A., Bengtsson J., Söderberg I., et al. Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis. Circulation 2004, 110:2047-2052.
8. Bason C., Corrocher R., Lunardi C., et al. Interaction of antibodies against cytomegalovirus with heat shock protein 60 in pathogenesis of atherosclerosis. Lancet 2003, 362:1971-1977.
9. Choi J.I., Chung S.W., Kang H.S., et al. Epitope mapping of Porphyromonas gingivalis heat-shock protein and human heat-shock protein in human atherosclerosis. J Dent Res 2004, 83:936-940.
10. Campbell L.A., Campbell L.A., O'Brien E.R., et al. Detection of Chlamydia pneumoniae TWAR in human coronary atherectomy tissues. J Infect Dis 1995, 172:585-588.
11. Sarén A., Pascolo S., Stevanovic S., et al. Identification of Chlamydia pneumoniae-derived mouse CD8 epitopes. Infect Immun 2002, 70:3336-3343.
12. Kadri R., Bermudez-Fajardo A., Puolakkainen M., Stewart G., Oviedo-Orta E. Effect of immunisation with Chlamydia pneumoniae recombinant major outer membrane protein on atherosclerosis development. Heart 2010, 96:e27.
13. Binz H.K., Pluckthun A. Engineered proteins as specific binding reagents. Curr Opin Biotechnol 2005, 16:459-469.
14. Sutcliffe M.J., Jaseja M., Hyde E.I., Lu X., Williams J.A. Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin. Nat Struct Biol 1994, 1:802-807.
15. Herbin O., Ait-Oufella H., Yu W., et al. Regulatory T-cell response to apolipoprotein b100-derived peptides reduces the development and progression of atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2012, 32:605-612.
16. Klingenberg R., Lebens M., Hermansson A., et al. Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 2010, 30:946-952.
17. Wang F., Lee E., Lowes M.A., et al. Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: gene regulation and cellular effects. J Invest Dermatol 2006, 126:1590-1599.
18. Fredrikson G.N., Schiopu A., Berglund G., Alm R., Shah P.K., Nilsson J. Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events. Atherosclerosis 2007, 194:e188-e192.
19. van Puijvelde G.H., Van Es T., van Wanrooij E.J., et al. Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:2677-2683.
20. Kohm A.P., Fuller K.G., Miller S.D. Mimicking the way to autoimmunity: an evolving theory of sequence and structural homology. Trends Microbiol 2003, 11:101-105.
21. Zhao R., Loftus D.J., Appella E., Collins E.J. Structural evidence of T-cell xeno-reactivity in the absence of molecular mimicry. J Exp Med 1999, 189:359-370.
22. Bobryshev Y.V. Dendritic cells in atherosclerosis: current status of the problem and clinical relevance. Eur Heart J 2005, 26:1700-1704.
23. Cybulsky M.I., Jongstra-Bilen J. Resident intimal dendritic cells and the initiation of atherosclerosis. Curr Opin Lipidol 2010, 21:397-403.
24. Habets K.L., van Puijvelde G.H., van Duivenvoorde L.M., et al. Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice. Cardiovasc Res 2010, 85:622-630.
25. Klingenberg R., Ketelhuth D.F., Strodthoff D., Gregori S., Hansson G.K. Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe-/- mice. Immunobiology 2012, 217:540-547.
26. Afek A., George J., Gilburd B., et al. Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. J Autoimmun 2000, 14:115-121.
27. George J., Afek A., Gilburd B., Shoenfeld Y., Harats D. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. J Am Coll Cardiol 2001, 38:900-905.
28. Zhou X., Hansson G.K. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice. Scand J Immunol 1999, 50:25-30.
29. Pinderski Oslund L.J., Hedrick C.C., Olvera T., et al. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler Thromb Vasc Biol 1999, 19:2847-2853.
30. Robertson A.K., Rudling M., Zhou X., Gorelik L., Flavell R.A., Hansson G.K. Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J Clin Invest 2003, 112:1342-1350.
31. Chang J.W., Mechling D.E., Bächinger H.P., Burrows G.G. Design, engineering, and production of human recombinant T cell receptor ligands derived from human leukocyte antigen DR2. J Biol Chem 2001, 276:24170-24176.
32. Gotsman I., Sharpe A.H., Lichtman A.H. T-cell costimulation and coinhibition in atherosclerosis. Circ Res 2008, 103:1220-1231.
33. Paulson K.E., Zhu S., Chen M., Nurmohamed S., Jongstra-Bilen J., Cybulsky M.I. Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 2010, 106:383-390.