Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells

Journal of Toxicological Sciences

Volumn 37, Issue 5, 2012, Pages 1049-1057

  Toyomura, Kaori ^a   Saito, Takeshi ^b   Emori, Syunsuke ^a   Matsumoto, Ikiru ^a   Kato, Erina ^a   Kaneko, Masayuki ^c   Okuma, Yasunobu ^c   Nakamura, Hiroyuki ^a   Murayama, Toshihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c CHIBA INSTITUTE OF SCIENCE   (Japan)

Author keywords

Arachidonic acid; Ceramide; Cytotoxicity; Geldanamycin; Hsp90; PC12 cells

Indexed keywords

4 CHLORO 7 NITROBENZOFURAZAN; ARACHIDONIC ACID; CERAMIDE; GELDANAMYCIN; HEXANOIC ACID; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; ORTHOVANADIC ACID; PHOSPHOLIPASE A2; RECOMBINANT EPIDERMAL GROWTH FACTOR; SORAFENIB; SPHINGOMYELIN; SPHINGOSINE; TANESPIMYCIN;

CELL FATE; CELL METABOLISM; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CYTOTOXICITY; DRUG EFFECT; HELA CELL; HUMAN; HUMAN CELL; LETTER; LIPID METABOLISM;

EID: 84867839799     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.1049     Document Type: Letter

References (29)

1. Beljanski, V., Knaak, C. and Smith, C.D. (2010): A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J. Pharmacol. Exp. Ther., 333, 454-464.
2. Clark, C.B., Rane, M.J., El Mehdi, D., Miller, C.J., Sachleben Jr, L.R. and Gozal, E. (2009): Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex. Free Radic. Biol. Med., 47, 1440-1449.
3. Doroshenko, N. and Doroshenko, P. (2007): Lanthanum suppresses arachidonic acid-induced cell death and mitochondrial depolarization in PC12 cells. Eur. J. Pharmacol., 567, 36-42.
4. Fukuyo, Y., Inoue, M., Nakajima, T., Higashikubo, R., Horikoshi, N.T., Hunt, C., Usheva, A., Freeman, M.L. and Horikoshi, N. (2008): Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Res., 68, 6324-6330.
5. Gerling, N., Culmsee, C., Klumpp, S. and Krieglstein, J. (2004): The tyrosine phosphatase inhibitor orthovanadate mimics NGFinduced neuroprotective signaling in rat hippocampal neurons. Neurochem. Int., 44, 505-520.
6. Hirabayashi, T., Murayama, T. and Shimizu, T. (2004): Regulatory mechanism and physiological role of cytosolic phospholipase A2. Biol. Pharm. Bull., 27, 1168-1173.
7. Kim, S., Kang, J., Hu, W., Evers, B.M. and Chung, D.H. (2003): Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. Int. J. Cancer, 103, 352-359.
8. Kurosawa, T., Nakamura, H., Yamaura, E., Fujino, H., Matsuzawa, Y., Kawashima, T. and Murayama, T. (2009): Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A2α-dependent and-independent release of arachidonic acid. J. Cell. Physiol., 219, 606-616.
9. Lu, A., Ran, R., Parmentier-Batteur, S., Nee, A. and Sharp, F.R. (2002): Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. J. Neurochem., 81, 355-364.
10. Lu, Y., Ansar, S., Michaelis, M.L. and Blagg, B.S.J. (2009): Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. Bioorg. Med. Chem., 17, 1709-1715.
11. Matsuzawa, Y., Kiuchi, Y., Toyomura, K., Matsumoto, I., Nakamura, H., Fujino, H., Murayama, T. and Kawashima, T. (2009): Activation of cytosolic phospholipase A2α by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-raf. J. Pharmacol. Sci., 111, 182-192.
12. Myung, S.J., Yoon, J.H., Kim, B.H., Lee, J.H., Jung, E.U. and Lee, H.S. (2009): Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells. J. Pharmacol. Exp. Ther., 330, 276-282.
13. Nakamura, H., Hirabayashi, T., Shimizu, M. and Murayama, T. (2006): Ceramide-1-phosphate activates cytosolic phospholipase A2α directly and by PKC pathway. Biochem. Pharmacol., 71, 850-857.
14. Nakamura, H., Yasufuku, K., Makiyama, T., Matsumoto, I., Fujino, H. and Murayama, T. (2012): Arachidonic acid metabolism via cytosolic phospholipase A2α induces cytotoxicity in Niemann-Pick disease type C cells. J. Cell. Physiol., 227, 2847-2855.
15. Posse de Chaves, E.I. (2006): Sphingolipids in apoptosis, survival and regeneration in the nervous system. Biochim. Biophys. Acta., 1758, 1995-2015.
16. Pratt, W.B. and Toft, D.O. (2003): Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med., 228, 111-133.
17. Romero, C., Benedi, J., Villar, A. and Martin-Aragon, S. (2010): Involvement of Hsp70, a stress protein, in the resistance of longterm culture of PC12 cells against sodium nitroprusside (SNP)-induced cell death. Arch. Toxicol., 84, 699-708.
18. Saito, M., Saito, M., Cooper, T.B. and Vadasz, C. (2005): Ethanolinduced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons. Alcohol. Clin. Exp. Res., 29, 1374-1383.
19. Salehi, A.H., Morris, S.J., Ho, W.C., Dickson, K.M., Doucet, G., Milutinovic, S., Durkin, J., Gillard, J.W. and Barker, P.A. (2006): AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem. Biol., 13, 213-223.
20. Sano, M. (2001): Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons. Neuropharmacology, 40, 947-953.
21. Shimma, N., Akiyama, N., Umezawa, M., Okuma, Y., Nomura, Y., Saito, T., Horie, S. and Murayama, T. (2003): Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline. J. Pharmacol. Sci., 93, 471-477.
22. Szanto, S., Csermely, P., Kovacs, I., Csongor, J., Illes, A., Bako, G., Szegedi, G. and Sipka, S. (2002): Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin. Immunol. Lett., 83, 181-185.
23. Tada, E., Toyomura, K., Nakamura, H., Sasaki, H., Saito, T., Kaneko, M., Okuma, Y. and Murayama, T. (2010): Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinasemediated pathway. J. Pharmacol. Sci., 114, 420-432.
24. Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H. and Murayama, T. (2006): Hydrogen peroxide-induced arachidonic acid release in L929 cells: roles of Src, protein kinase C and cytosolic phospholipase A2α. Eur. J. Pharmacol., 546, 1-10.
25. Taniguchi, T., Shimizu, M., Nakamura, H., Hirabayashi, T., Fujino, H., Saito, T. and Murayama, T. (2007): Vanadate-induced activation of cytosolic phospholipase A2α in L929 cells: roles of tyrosine kinase, protein kinase C, and extracellular signal-regulated kinase. Biochem. Pharmacol., 73, 854-862.
26. Tucker, D.E., Gijon, M.A., Spencer, D.M., Qiu, Z.-H., Gelb, M.H. and Leslie, C.C. (2008): Regulation of cytosolic phospholipase A2α by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. J. Leukoc. Biol., 84, 798-806.
27. Walker, T., Mitchell, C., Park, M.A., Yacoub, A., Rahmani, M., Haussinger, D., Reinehr, R., Voelkel-Johnson, C., Fisher, P.B., Grant, S. and Dent, P. (2010): 17-Allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Mol. Cancer Ther., 9, 1378-1395.
28. Wandinger, S.K., Richter. K. and Buchner, J. (2008): The Hsp90 chaperone machinery. J. Biol. Chem., 283, 18473-18477.
29. Zheng, W.H., Kar, S. and Quirion, R. (2000): Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J. Biol. Chem., 275, 39152-39158.