Unconventional chemiosmotic coupling of NHA2, a mammalian Na +/H+ antiporter, to a plasma membrane H+ gradient

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36239-36250

  Kondapalli, Kalyan C ^a   Kallay, Laura M ^a   Muszelik, Melanie ^a   Rao, Rajini ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMIOSMOTIC COUPLING; COUPLED TRANSPORT; EFFLUX PUMPS; ELECTROCHEMICAL GRADIENTS; ESSENTIAL HYPERTENSION; EVOLUTIONARY ORIGIN; GENE LINKAGE; MAMMALIAN CELLS; MDCK CELLS; PH REGULATION; TISSUE DISTRIBUTIONS;

MAMMALS;

CELL MEMBRANES;

ADENOSINE TRIPHOSPHATASE; HYDROGEN; LITHIUM; PHLORETIN; SODIUM; SODIUM PROTON EXCHANGE PROTEIN;

ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MAMMAL CELL; PH; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT TOLERANCE; SENSITIVITY ANALYSIS; SODIUM TRANSPORT; TISSUE DISTRIBUTION;

ANIMALS; ANTIPORTERS; CELL LINE; CELL MEMBRANE; DOGS; HUMANS; KIDNEY; PROTON-MOTIVE FORCE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84867822593     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.403550     Document Type: Article

References (29)

1. Xiang, M., Feng, M., Muend, S., and Rao, R. (2007) A human Na+/H+antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. Proc. Natl. Acad. Sci. U.S.A. 104, 18677-18681
2. Carretero, O. A., and Oparil, S. (2000) Essential hypertension. Part I: definition and etiology. Circulation 101, 329-335 (Pubitemid 30054162)
3. Weder, A. B. (1986) Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension. N. Engl. J. Med. 314, 198-201
4. Lifton, R. P., Hunt, S. C., Williams, R. R., Pouysségur, J., and Lalouel, J. M. (1991) Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension. Hypertension 17, 8-14
5. Canessa, M., Adragna, N., Solomon, H. S., Connolly, T. M., and Tosteson, D. C. (1980) Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N. Engl. J. Med. 302, 772-776 (Pubitemid 10130566)
6. Morrison, A. C., Boerwinkle, E., Turner, S. T., and Ferrell, R. E. (2005) Genome-wide linkage study of erythrocyte sodium-lithium countertransport. Am. J. Hypertens. 18, 653-656 (Pubitemid 40692432)
7. Fuster, D. G., Zhang, J., Shi, M., Bobulescu, I. A., Andersson, S., and Moe, O. W. (2008) Characterization of the sodium/hydrogen exchanger NHA2. J. Am. Soc. Nephrol. 19, 1547-1556
8. Ecelbarger, C. A., and Tiwari, S. (2006) Sodium transporters in the distal nephron and disease implications. Curr. Hypertens Rep. 8, 158-165 (Pubitemid 43796694)
9. Padan, E., Bibi, E., Ito, M., and Krulwich, T. A. (2005) Alkaline pH homeostasis in bacteria: new insights. Biochim. Biophys. Acta 1717, 67-88 (Pubitemid 41682429)
10. Padan, E., Kozachkov, L., Herz, K., and Rimon, A. (2009) NhaA crystal structure: functional-structural insights. J. Exp. Biol. 212, 1593-1603
11. Mager, T., Rimon, A., Padan, E., and Fendler, K. (2011) Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological study. J. Biol. Chem. 286, 23570-23581
12. Kallay, L. M., McNickle, A., Brennwald, P. J., Hubbard, A. L., and Braiterman, L. T. (2006) Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains. J. Cell. Biochem. 99, 647-664 (Pubitemid 44435580)
13. Canessa, M. (1995) Red cell sodium-lithium countertransport and cardiovascular risk factors in essential hypertension. Trends Cardiovasc. Med. 5, 102-108
14. Zerbini, G., Mangili, R., Gabellini, D., and Pozza, G. (1997) Modes of operation of an electroneutral Na+/Li+ countertransport in human skin fibroblasts. Am. J. Physiol. 272, C1373-C1379
15. Akhter, S., Cavet, M. E., Tse, C. M., and Donowitz, M. (2000) C-terminal domains of Na(+)/H(+) exchanger isoform 3 are involved in the basal and serum-stimulated membrane trafficking of the exchanger. Biochemistry 39, 1990-2000 (Pubitemid 30124007)
16. Helmle-Kolb, C., Di Sole, F., Forgo, J., Hilfiker, H., Tse, C. M., Casavola, V., Donowitz, M., and Murer, H. (1997) Regulation of the transfected Na+/H+-exchanger NHE3 in MDCK cells by vasotocin. Pflugers Arch. 434, 123-131 (Pubitemid 27190443)
17. Mohan, S., Tse, C. M., Gabelli, S. B., Sarker, R., Cha, B., Fahie, K., Nadella, M., Zachos, N. C., Tu-Sekine, B., Raben, D., Amzel, L. M., and Donowitz, M. (2010) NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. J. Biol. Chem. 285, 34566-34578
18. Pouysségur, J., Sardet, C., Franchi, A., L'Allemain, G., and Paris, S. (1984)A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc. Natl. Acad. Sci. U.S.A. 81, 4833-4837 (Pubitemid 14066209)
19. Wegmann, M., and Nüsing, R. M. (2003) Prostaglandin E2 stimulates sodium reabsorption in MDCKC7 cells, a renal collecting duct principal cell model. Prostaglandins Leukot Essent Fatty Acids 69, 315-322 (Pubitemid 37346664)
20. Lahr, T. F., Record, R. D., Hoover, D. K., Hughes, C. L., and Blazer-Yost, B. L. (2000) Characterization of the ion transport responses to ADH in the MDCK-C7 cell line. Pflugers Arch. 439, 610-617 (Pubitemid 30140154)
21. Kammerer, C. M., Cox, L. A., Mahaney, M. C., Rogers, J., and Shade, R. E. (2001) Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. Hypertension 37, 398-402 (Pubitemid 32199000)
22. Lee, B. L., Sykes, B. D., and Fliegel, L. (2011) Structural analysis of the Na+/H+ exchanger isoform 1 (NHE1) using the divide and conquer approach. Biochimie Biologie Cellulaire 89, 189-199
23. Saroussi, S., and Nelson, N. (2009) Vacuolar H(+)-ATPase-an enzyme for all seasons. Pflugers Arch. 457, 581-587
24. Jefferies, K. C., Cipriano, D. J., and Forgac, M. (2008) Function, structure, and regulation of the vacuolar (H+)-ATPases. Arch. Biochem. Biophys. 476, 33-42
25. Brett, C. L., Donowitz, M., and Rao, R. (2005) Evolutionary origins of eukaryotic sodium/proton exchangers. Am. J. Physiol. Cell Physiol. 288, C223-C239 (Pubitemid 40105332)
26. Schushan, M., Xiang, M., Bogomiakov, P., Padan, E., Rao, R., and Ben-Tal, N. (2010) J. Mol. Biol. 396, 1181-1196
27. Anderson, C. M., and Thwaites, D. T. (2010) Hijacking solute carriers for proton-coupled drug transport. Physiology 25, 364-377
28. Harvey, W. R. (2009) Voltage coupling of primary H+ V-ATPases to secondary Na+- or K+-dependent transporters. J. Exp. Biol. 212, 1620-1629
29. Verkoelen, C. F., van der Boom, B. G., Kok, D. J., Houtsmuller, A. B., Visser, P., Schröder, F. H., and Romijn, J. C. (1999) Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture. Kidney Int. 55, 1426-1433 (Pubitemid 29157141)