Modes of operation of an electroneutral Na+/Li+ countertransport in human skin fibroblasts

American Journal of Physiology - Cell Physiology

Volumn 272, Issue 4 41-4, 1997, Pages

  Zerbini, Gianpaolo ^a   Mangili, Ruggero ^a,b   Gabellini, Daniela ^a   Pozza, Guido ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

amiloride; phloretin; sodium hydrogen exchange

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; LITHIUM; PHLORETIN; SODIUM ION;

ARTICLE; CELL PH; DRUG TRANSPORT; ERYTHROCYTE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SKIN FIBROBLAST; SODIUM TRANSPORT;

EID: 0030898877     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.272.4.c1373     Document Type: Article

References (17)

1. Aronson, P. S. Red-cell sodium-lithium countertransport and essential hypertension. N. Engl. J. Med. 307: 317, 1982.
2. Aronson, P. S. Kinetic properties of the plasma membrane Na-H exchanger. Annu. Rev. Physiol. 47: 545-560, 1985.
3. Aronson, P. S., J. Nee, and M. A. Suhm. Modifier role of internal H in activating the Na-H exchanger in renal microvillus membrane vesicles. Nature 299: 161-163, 1982.
4. Benos, D. J. Amiloride: a molecular probe of sodium transport in tissues and cells. Am. J. Physiol. 242 (Cell Physiol. 11): C131-C145, 1982.
5. Berk, B. C., M. S. Aronow, T. A. Brock, E. G. Cragoe, Jr., M. A. Gimbrone, and R. W. Alexander. Angiotensin II-stimulated Na/H exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways. J. Biol. Chem. 262: 5057-5064, 1987.
6. Boerwinkle, E., S. T. Turner, R. Weishilboum, M. Johnson, E. Richelson, and C. F. Sing. Analysis of the distribution of erythrocyte sodium-lithium countertransport in a sample representative of the general population. Genet. Epidemiol. 3: 365-378, 1986.
7. Busch, S., B. C. Burckhardt, and W. Siffert. Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport. Pflügers Arch. 429: 859-869, 1995.
8. Canessa, M. Kinetic properties of Na/H exchange and Li/Na, Na/Na, and Na/Li exchanges of human red cells. Methods Enzymol. 173: 176-191, 1989.
9. Canessa, M., N. Adragna, H. S. Solomon, T. M. Connolly, and D. C. Tosteson. Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N. Engl. J. Med. 302: 772-776, 1980.
10. Canessa, M., I. Bize, N. Adragna, and D. C. Tosteson. Cotransport of lithium and potassium in human red cells. J. Gen. Physiol. 80: 149-168, 1982.
11. Canessa, M., K. Morgan, and A. Semplicini. Genetic differences in lithium-sodium exchange and regulation of the sodium-hydrogen exchanger in essential hypertension. J. Cardiovasc. Pharmacol. 12, Suppl. 3: 92-98, 1988.
12. Canessa, M., G. Zerbini, and L. M. B. Laffel. Sodium activation kinetics of red blood cell Na/Li countertransport in diabetes: methodology and controversy. J. Am. Soc. Nephrol. 3: S41-S49, 1992.
13. Corry, D., M. L. Tuck, S. Nicholas, and E. J. Weinman. Increased Na/H antiport activity and abundance in uremic red blood cells. Kidney Int. 44: 574-578, 1993.
14. Davies, J. E., L. L. Ng, A. Kofoed-Enevoldsen, L. K. Li, K. A. Earle, R. Trevisan, and G. C. Viberti. Intracellular pH and Na/H antiport activity of cultured skin fibroblasts from diabetics. Kidney Int. 42: 1184-1190, 1992.
15. Duhm, J., and B. F. Becker. Studies on lithium transport across the red cell membrane. V. On the nature of the Na-dependent Li countertransport system of mammalian erythrocytes. J. Membr. Biol. 51: 263-286, 1979.
16. Dunham, P. B., and O. Senyk. Lithium efflux through the Na/K pump in human erythrocytes. Proc. Natl. Acad. Sci. USA 74: 3099-3103, 1977.
17. Ehrlich, B. E., and J. M. Diamond. Lithium fluxes in human erythrocytes. Am. J. Physiol. 237 (Cell Physiol. 6): C102-C110, 1979.