Novel thermo/pH sensitive nanogels composed from poly(N-vinylcaprolactam) for controlled release of an anticancer drug

Colloids and Surfaces B: Biointerfaces

Volumn 102, Issue , 2013, Pages 891-897

  Madhusudana Rao, K ^a   Mallikarjuna, B ^a   Krishna Rao, K S V ^b   Siraj, S ^a   Chowdoji Rao, K ^a   Subha, M C S ^a  

^a SRI KRISHNADEVARAYA UNIVERSITY   (India)

^b YOGI VEMANA UNIVERSITY   (India)

Author keywords

Anti cancer drug; Controlled release; Diffusion; Nanogels; Thermo and pH responsive

Indexed keywords

ANTICANCER DRUG; AVERAGE DIAMETER; CONTROLLED RELEASE; DIFFUSION EXPONENT; EMPERICAL EQUATION; ENCAPSULATION EFFICIENCY; EQUILIBRIUM SWELLING; FICKIAN DIFFUSION; FTIR; IN-VITRO; NANOGELS; PH-RESPONSIVE; POTENTIAL DRUG; STRUCTURE AND MORPHOLOGY; THERMO-RESPONSIVE; TRANSMISSION ELECTRON MICROSCOPY TEM;

DIFFUSION; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; EMULSIFICATION; ENCAPSULATION; FOURIER TRANSFORMS; FREE RADICALS; INFRARED SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

NANOSTRUCTURED MATERIALS;

COPOLYMER; FLUOROURACIL; NANOGEL; NANOPARTICLE; POLY(N VINYLCAPROLACTAM CO ACRYLAMIDOGLYCOLIC ACID); UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; ENCAPSULATION; HEAT SENSITIVITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIGHT SCATTERING; MATHEMATICAL ANALYSIS; MORPHOLOGY; PARTICLE SIZE; PH; PRIORITY JOURNAL; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS; CAPROLACTAM; FLUOROURACIL; HYDROGEN-ION CONCENTRATION; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; TEMPERATURE;

EID: 84867821318     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2012.09.009     Document Type: Article

References (42)

1. Harris J.M., Chess R.B. Effect of PEGylation on pharmaceuticals. Nat. Rev. Drug Discov. 2003, 2:214.
2. Vicent M.J., Greco F., Nicholson R.I., Paul A., Griffiths P.C., Duncan R. Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angew. Chem. Int. Ed. 2005, 44:4061.
3. Nishiyama N., Kataoka K. Nanostructured devices based on block copolymer assemblies for drug delivery: designing structures for enhanced drug function. Adv. Polym. Sci. 2006, 193:67.
4. Harada A., Kataoka K. Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications. Prog. Polym. Sci. 2006, 31:949.
5. Wu J., Eisenberg A. Proton diffusion across membranes of vesicles of poly (styrene-b-acrylic acid) diblock copolymers. J. Am. Chem. Soc. 2006, 128:2880.
6. Tomalia D.A. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog. Polym. Sci. 2005, 30:294.
7. Kim S.H., Jeong J.H., Chun K.W., Park T.G. Target-specific cellular uptake of PLGA nanoparticles coated with poly (l-lysine)-poly(ethylene glycol)-folate conjugate. Langmuir 2005, 21:8852.
8. Xiong W., Wang W., Wang Y., Zhao Y., Chen H., Xu H., Yang X. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy. Colloids Surf. B: Biointerfaces 2011, 84:447.
9. Meeussen F., Nies E., Bergmans H., Verbrugghe S., Goethals E., Du Prez F. Phase behaviour of poly (N-vinyl caprolactam) in water. Polymer 2000, 41:8597.
10. Vihola H., Laukkanen A., Valtola L., Tenhu H. Hirvonen, cytotoxicity of thermosensitive polymers poly(N-isopropyl acrylamide), poly(N-vinyl caprolactam) and amphiphilically modified poly(N-vinyl caprolactam). J. Biomater. 2005, 26:3055.
11. Krish Y.E., Yanyul, Popkov Y.M., Timashev S.F. Poly (N-vinyl caprolactam) hydrate complex as model detector for determination of the state of water-salt systems. J. Phys. Chem. 1999, 73:313.
12. Lau A.C.W., Wu C. Thermally sensitive and biocompatible poly (N-vinyl caprolactam): synthesis and characterization of high molar mass linear chains. Macromolecules 1999, 32:581.
13. Maeda Y., Nakamura T., Ikeda I. Hydration and phase behaviour of poly (N-vinyl caprolactam) and poly (N-vinyl pyrrolidone) in water. Macromolecules 2002, 35:1870.
14. Shtanko N.I., Wounter L., Geothals E.J., Du Prez F.E. pH and thermoresponsive properties of poly (N-vinyl caprolactam-co-acrylic acid) copolymers. Polym. Int. 2003, 52:1605.
15. Nagaraj D.R., Rothenberg A.S., Lipp D.W., Panzer H.P. Low molecular weight polyacrylamide-based polymers as modifiers in phosphate beneficiation. Int. J. Miner. Process. 1987, 20:291.
16. Leroy D., Maritinot L., Jerome C., Jerome R. Determination of the stability constants of uranyl/polymer complexes by differential pulse polarography. Polymer 2001, 42:4589.
17. Rivas B.L., Quilodran B., Quiroz E. Metal ion retention properties of water-insoluble polymers containing carboxylic acid groups. J. Appl. Polym. Sci. 2006, 99:697.
18. Krishna Rao K.S.V., Ha C.S. pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics: drug delivery application. Polym. Bull. 2009, 62:167.
19. Krishan Rao K.S.V., Madhusudhan Rao K., Nagendra Kumar P.V., Ildoo C. Novel chitosan-based pH sensitive micro-networks for the controlled release of 5-Fluorouracil. Iran. Polym. J. 2010, 19:265.
20. Krishna Rao K.S.V., Ildoo C., Ha C.S. Synthesis and characterization of poly(acrylamidoglycolic acid) grafted onto chitosan and its polyelectrolyte complexes with hydroxyapatite. React. Funct. Polym. 2008, 68:943.
21. Nayak S., Bhattacharjee S., Chaudhary Y.S. In situ encapsulation and release kinetics of pH and temperature responsive nanogels. J. Phys. Chem. C 2012, 116:30.
22. Bhuchar N., Sunasee R., Ishihara K., Thomas T., Ravin N. Degradable thermoresponsive nanogels for protein encapsulation and controlled release. Bioconjugate Chem. 2012, 23:75.
23. Argentiere S., Blasi L., Morello G., Gigli G. A novel pH-responsive nanogel for the controlled uptake and release of hydrophobic and cationic solutes. J. Phys. Chem. C 2011, 115:16347.
24. Heidelberger C. Cancer Medicine 1982, Lea and Febiger, Philadelphia, p. 801. 2nd ed.
25. Waxman S., Scanlon K.J., Greenspan E.M. Clinical Interpretation and Practice in Chemotherapy 1982, Raven Press, New York, p. 39.
26. Sommadossi J.P., Gewirtz D.A., Diasio R.B., Aubert C., Cano J.P., Goldman I.D. Rapid catabolism of 5-fluorouracil in freshly isolated rathepatocytes as analyzed by high performance liquid chromatography. J. Biol. Chem. 1982, 257:8171.
27. Einmahl S., Zignani M., Varesio E., Heller J., Veuthey J.L., Tabatabay C., Gurny R. Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly (ortho ester). Int. J. Pharm. 1999, 185:189.
28. Fournier E., Passirani C., Colin N., Bretona P., Sagodiraa S., Benoitb J.P. Development of novel 5-FU-loaded poly (methylidene malonate 2.1.2)-based microspheres for the treatment of brain cancers. Eur. J. Pharm. Biopharm. 2004, 57:189.
29. Ermis D., Yuksel A. Preparation of spray-dried microspheres of indomethacin and examination of the effects of coating on dissolution rates. J. Microencapsul. 1999, 16:315.
30. Parker W.B., Cheng Y.C. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol. Ther. 1990, 48:381.
31. Garcia O., Trigo Blanco R.M.M.D., Teijon J.M. Influence of degree of crosslinking on 5-fluorouacil release from poly(2-hydroxyethyl methacrylate) hydrogels. Biomaterials 1994, 15:689.
32. Peisker V. Vademecum Internacional 1994, Medicom, Madrid, p. 848.
33. Malmsten M. Soft drug delivery systems. Soft Matter 2006, 2:760.
34. Napier M.E., Desimone J.M. Nanoparticle drug delivery platform. Polym. Rev. 2007, 47:321.
35. Rzaev Z.M.O., Dinçer S., Pişkin E. Functional copolymers of N-isopropylacrylamide for bioengineering applications. Prog. Polym. Sci. 2007, 32:534.
36. Dai S., Ravi P., Tam K.C. pH-responsive polymers: synthesis, properties and applications. Soft Matter 2008, 4:435.
37. Sahana D.K., Mittal G., Bharadvaj V., Kumar M.N.V. PLGA nanoparticles for oral delivery of hydrophobic drugs: influence of organic solvent on nanoparticles formation and release behavior in vitro and in vivo using estradiol as a model drug. J. Pharm. Sci. 2008, 97:1530.
38. Zambaux M.F., Bonneaux F., Dellacherie E., Vigneron C. Preparation and characterization of protein c-loaded PLA nanoparticles. J. Control. Release 1999, 60:179.
39. Pinto Reis C., Ronald J.N., Ribeiro A.J., Veiga F. Nanoencapsulation I. Methods for preparation of drug loaded polymeric nanoparticles. Nanomedicine 2006, 2:8.
40. Moghimi S.M., Hunter A.C., Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 2001, 53:283.
41. Ritger P.L., Peppas N.A. A simple equation for description of solute release II. Fickian and anomolous release from swellable devices. J. Control. Release 1987, 5:37.
42. Siepmann J., Peppas N.A. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Deliv. Rev. 2001, 48:139.