Thyroid volume influences serum calcitonin levels in a thyroid-healthy population: Results of a 3-assay, 519 subjects study

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 5, 2012, Pages 895-900

  Giovanella, Luca ^a,b   Imperiali, Mauro ^b   Ferrari, Anna ^c   Palumbo, Alessia ^b   Lippa, Lorella ^c   Peretti, Andrea ^c   Graziani, Maria Stella ^c   Castello, Roberto ^c   Verburg, Frederik A ^d  

^a ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^b REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^c UNIVERSITY HOSPITAL OF VERONA   (Italy)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Calcitonin; Immunoassay; Medullary thyroid carcinoma; Reference range; Thyroid ultrasound

Indexed keywords

CALCITONIN;

ADULT; ARTICLE; CALCITONIN BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ECHOGRAPHY; FEMALE; HORMONE DETERMINATION; HUMAN; IMMUNOASSAY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; REFERENCE VALUE; SEX DIFFERENCE; THYROID ULTRASONOGRAPHY; THYROID WEIGHT;

ADULT; BLOOD CHEMICAL ANALYSIS; CALCITONIN; FEMALE; HEALTH; HUMANS; IMMUNOASSAY; LIMIT OF DETECTION; MALE; MULTIVARIATE ANALYSIS; ORGAN SIZE; REFERENCE VALUES; THYROID GLAND;

EID: 84867816856     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2011-0920     Document Type: Article

References (26)

1. Karges W, Dralle HH, Raue F, Mann K, Reiners C, Grussendorf M, et al. German Society for Endocrinology (DGE): Thyroid Section. Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation. Exp Clin Endocrinol Diabetes 2004;112:52-8.
2. Costante G, Meringolo D, Durante C, Bianchi D, Nocera M, Tumino S, et al. Predictive value of serum calcitonin levels for pre-operative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab 2007;92:450-5.
3. Chambon G, Alovisetti C, Idoux-Louche C, Reynaud C, Rodier M, Guedj AM, et al. The use of preoperative routine measurement of basal serum thyrocalcitonin in candidates for thyroi-dectomy due to nodular thyroid disorders: results from 2733 consecutive patients. J Clin Endocrinol Metab 2011;96:75-81.
4. Barbot N, Calmettes C, Schuffenecker I, Saint-Andrè JP, Franc B, Rohmer V, et al. Pentagastrin stimulation test and early diagnosis of medullary thyroid carcinoma using an immunoradio-metric assay of calcitonin: comparison with genetic screening in hereditary medullary thyroid carcinoma. J Clin Endocrinol Metab 1994;78:114-20.
5. Doyle P, Dueren C, Nerlich K, Verburg FA, Grelle I, Jahn H, et al. Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults. J Clin Endocrinol Metab 2009;94:2970-4.
6. Grauer R, Raue F, Ziegler R. Clinical usefulness of a new chemi-luminescent two-site immunoassay for human calcitonin. Exp Clin Endocrinol Diabetes 1998;106:353-9.
7. Bieglmayer C, Vierhapper H, Dudczack R, Niederle B. Measurement of calcitonin by immunoassay analyzers. Clin Chem Lab Med 2007;45:662-6.
8. D'Herbomez M, Caron P, Bauters C, Do Cao C, Schlienger JL, Sapin R, et al. Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking. Eur J Endocrinol 2007;157:749-55.
9. Ramachandran R, Benfield P, Dhillo WS, White S, Chapman R, Meeran K, et al. Need for revision of diagnostic limits for medullary thyroid carcinoma with a new immunochemiluminometric calcitonin assay. Clin Chem 2009;55:2225-6.
10. Cavalier E, Carlisi A, Chapella JP, Delanaye P. Analytical quality of calcitonin determination and its effect on the adequacy of screening from medullary carcinoma of the thyroid. Clin Chem 2008;54:2008-9.
11. Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 2009;19:565-616.
12. Algeciras-Schimnich A, Preissenr CM, Theobald P, Finseth MS, Grebe SK. Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma. J Clin Endocrinol Metab 2009;94:861-8.
13. Vantyghem MC, Danel T, Marcelli-Tourvielle S, Moriau J, Leclerc L, Cardot-Bauters C, et al. Calcitonin levels do not decrease with weaning in chronic alcoholism. Thyroid 2007;17:213-7.
14. Giovanella L, Suriano S. Spurious hypercalcitoninemia and hete-rophilic antibodies in patients with thyroid nodules. Head Neck 2010;33:95-7.
15. Castro MR, Gharib H. Continuing controversies in the management of thyroid nodules. Ann Intern Med 2005;142:926-31.
16. Kratzsch J, Fiedler GM, Leichtle A, Brügel M, Buchbinder S, Otto L, et al. New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid. Clin Chem 2005;51:1480-6.
17. Giovanella L, Imperiali M, Ferrari A, Palumbo A, Furlani L, Graziani MS, et al. Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound. Clin Chem Lab Med 2012;50:891-3.
18. Andermann P, Shoegl S, Maeder U, Luster M, Lassmann M, Reiners C. Intra-and interobserver variability of thyroid volume measurements in healthy adults by 2D versus 3D ultrasound. Nuklearmedizin 2007;46:1-7.
19. Andrioli M, Attard M, Valcavi R. Ecografia ed eco-Doppler in: Associazione Medici Endocrinologi. Manuale per la valutazi-one e l'inquadramento delle patologie tiroidee. Verona: Scripta Editore, 2011:141-3.
20. Kratzsch J, Petzold A, Raue F, Reinhardt W, Bröcker-Preuss M, Görges R, et al. Basal and stimulated calcitonin and procalcitonin in various assays in patients with and without medullary thyroid cancer. Clin Chem 2011;57:467-74.
21. Plebani M. Biochemical and imaging biomarkers: the search for the Holy Grail. Clin Chem Lab Med 2010;48:1055-6.
22. Costante G, Durante C, Francis Z, Schlumberger M, Filetti S. Determination of calcitonin in C-cell disease: clinical interest and potential pitfalls. Nat Clin Pract Endocrinol Metab 2009;5:35-44.
23. Trimboli P, Rossi E, Condorelli E, Laurenti O, Ventura C, Nigri G, et al. Does normal thyroid gland by ultrasonogra-phy match with normal serum thyroid hormones and negative thyroid antibodies ? Exp Clin Endocrinol Diabet 2010;118:630-2.
24. Huftless S, Matos P, Talor MV, Caturegli P, Rose NR. Signifi-cance of prediagnostic thyroid autoantibodies in women with thyroid disease. J Clin Endocrinol Metab 2011;96:1466-71.
25. Pedersen OM, Aardal NP, Larssen TB, Varhaug JE, Myking O, Vik-Mo H. The value of ultrasound in predicting autoimmune thyroid disease. Thyroid 2000;10:251-9.
26. Martin-Lacave I, Borrero MJ, Utrilla JC, Fernandez-Santos JM, De Miquel M, Morillo J, et al. C-cells evolve at the same rhythm as follicular cells when thyroidal status changes in rats. J Anatom 2009;214:301-9.