Pathogenesis of hepatitis B virus infection and potential for new therapies

British Journal of Hospital Medicine

Volumn 73, Issue 10, 2012, Pages 581-584

  Peppa, Dimitra ^a   Maini, Mala K ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84867787919     PISSN: 17508460     EISSN: None     Source Type: Journal    
DOI: 10.12968/hmed.2012.73.10.581     Document Type: Article

References (33)

1. Ando K, Moriyama T, Guidotti LG et al (1993) Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 178:1541-54 (Pubitemid 23318433)
2. Bertoletti A, Gehring A (2009) Therapeutic vaccination and novel strategies to treat chronic HBV infection. Expert Rev Gastroenterol Hepatol 3:561-9
3. Bertoletti A, Ferrari C (2011) Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut Dec. 9 (Epub ahead of print)
4. Bertoletti A, Maini MK, Ferrari C (2010) The host-pathogen interaction during HBV infection: immunological controversies. Antivir Ther 15(Suppl 3):15-24
5. Boni C, Fisicaro P, Valdatta C et al (2007) Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol 81:4215-25 (Pubitemid 46586915)
6. Das A, Hoare M, Davies N et al (2008) Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J Exp Med 205:2111-24
7. Dunn C, Brunetto M, Reynolds G et al (2007) Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 204:667-80 (Pubitemid 46457088)
8. Dunn C, Peppa D, Khanna P et al (2009) Temporal analysis of early immune responses in patients with acute hepatitis B virus infection. Gastroenterology 137:1289-300
9. Fattovich G, Olivari N, Pasino M, D'Onofrio M, Martone E, Donato F (2008) Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years. Gut 57:84-90
10. Ha SJ, Mueller SN, Wherry EJ et al (2008) Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med 205:543-55 (Pubitemid 351439302)
11. Ilan Y, Nagler A, Adler R, Tur-Kaspa R, Slavin S, Shouval D (1993) Ablation of persistent hepatitis B by bone marrow transplantation from a hepatitis B-immune donor. Gastroenterology 104:1818-21 (Pubitemid 23235477)
12. Knolle PA, Schmitt E, Jin S et al (1999) Induction of cytokine production in naive CD4 (+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116:1428-40 (Pubitemid 29258892)
13. Lavanchy D (2004) Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepatitis 11:97-107 (Pubitemid 38365759)
14. Liaw Y F, Chu CM (2009) Hepatitis B virus infection. Lancet 373:582-92
15. Locarnini S, Zoulim F (2010) Molecular genetics of HBV infection. Antivir Ther 15(Suppl 3):3-14
16. Lopes AR, Kellam P, Das A et al (2008) Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection. J Clin Invest 118:1835-45 (Pubitemid 351632386)
17. Maini MK, Schurich A (2010) The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J Hepatol 52:616-19
18. Maini MK, Boni C, Lee CK et al (2000) The role of virus-specific CD8 (+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 191:1269-80 (Pubitemid 30227116)
19. Manigold T, Racanelli V (2007) T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infect Dis 7:804-13 (Pubitemid 350152043)
20. Milich D, Liang TJ (2003) Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 38:1075-86 (Pubitemid 37314815)
21. Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A (1990) Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci USA 87:6599-603
22. Papatheodoridis GV, Manolakopoulos S, Dusheiko G, Archimandritis AJ (2008) Therapeutic strategies in the management of patients with chronic hepatitis B virus infection. Lancet Infect Dis 8:167-78 (Pubitemid 351249242)
23. Peppa D, Micco L, Javaid A et al (2010) Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS pathogens 6:e1001227
24. Protzer U, Maini MK, Knolle PA (2012) Living in the liver: hepatic infections. Nat Rev Immunol 12:201-13
25. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5:215-29 (Pubitemid 40364823)
26. Rehermann B, Fowler P, Sidney J et al (1995) The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 181:1047-58
27. Schurich A, Khanna P, Lopes AR et al (2011) Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology 53:1494-503
28. Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV (2003) CD8 (+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 77:68-76 (Pubitemid 36004947)
29. Van Der Molen RG, Sprengers D, Binda RS et al (2004) Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology 40:738-46 (Pubitemid 39265597)
30. Webster GJ, Reignat S, Brown D et al (2004) Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J Virol 78:5707-19 (Pubitemid 38661658)
31. Wherry EJ, Blattman JN, Murali-Krishna K, Van Der Most R, Ahmed R (2003) Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 77:4911-27 (Pubitemid 36402840)
32. Wieland S F, Chisari FV (2005) Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol 79:9369-80
33. Wieland S, Thimme R, Purcell RH, Chisari FV (2004) Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci USA 101:6669-74 (Pubitemid 38586032)