Localization of hepatocyte nuclear factor-4α in the nucleolus and nucleus is regulated by its C-terminus

Journal of Diabetes Investigation

Volumn 3, Issue 5, 2012, Pages 449-456

  Ogata, Makiko ^a   Awaji, Takeo ^b   Iwasaki, Naoko ^a   Fujimaki, Risa ^a   Takizawa, Miho ^a   Maruyama, Kei ^b   Bell, Graeme I ^c   Iwamoto, Yasuhiko ^a   Uchigata, Yasuko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Fluorescence resonance energy transfer; Hepatocyte nuclear factor 4 ; Nucleolus

Indexed keywords

CELL PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MUTANT PROTEIN; SMALL HETERODIMER PARTNER PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CHO CELL; CONTROLLED STUDY; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE DELETION; GENETIC REGULATION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; INSULINOMA; MOLECULAR INTERACTION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; RAT; WILD TYPE;

EID: 84867768092     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/j.2040-1124.2012.00210.x     Document Type: Article

References (26)

1. Yamagata K, Furuta H, Oda N, et al. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 1996; 384: 458-460.
2. Furuta H, Iwasaki N, Oda N, et al. Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY. Diabetes 1997; 46: 1652-1657.
3. Fajans SS. Maturity-onset diabetes of the young (MODY). Diabetes Metab Rev 1989; 5: 579-606.
4. Gupta R, Vatamaniuk M, Lee C, et al. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest 2005; 115: 1006-1015.
5. Crossley M, Ludwig M, Stowell KM, et al. Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter. Science 1992; 257: 377-379.
6. Sugai M, Umezu H, Yamamoto T, et al. Expression of hepatocyte nuclear factor 4 alpha in primary ovarian mucinous tumors. Pathol Int 2008; 58: 681-686.
7. Sel S, Ebert T, Ryffel GU, et al. Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4 alpha and HNF1 alpha. Cancer Lett 1996; 101: 205-210.
8. Tanaka T, Jiang S, Hotta H, et al. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. J Pathol 2006; 208: 662-672.
9. Ryffel GU. Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol 2001; 27: 11-29.
10. Ellard S, Colclough K. Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young. Hum Mutat 2006; 27: 854-869.
11. Jiang G, Nepomuceno L, Hopkins K, et al. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 1995; 15: 5131-5143.
12. Bogan AA, Dallas-Yang Q, Ruse MD Jr, et al. Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. J Mol Biol 2000; 302: 831-851.
13. Laine B, Eeckhoute J, Suaud L, et al. Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1. FEBS Lett 2000; 479: 41-45.
14. Sladek FM, Dallas-Yang Q, Nepomuceno L. MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization. Diabetes 1998; 47: 985-990.
15. Miura A, Yamagata K, Kakei M, et al. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem 2006; 281: 5246-5257.
16. Nishigori H, Tomura H, Tonooka N, et al. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci USA 2001; 98: 575-580.
17. Zhang Y, Soto J, Park K, et al. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol 2010; 30: 1341-1356.
18. Ogata M, Awaji T, Iwasaki N, et al. Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells. Biochem Biophys Res Commun 2002; 292: 8-12.
19. Miyazaki J, Araki K, Yamato E, et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 1990; 127: 126-132.
20. Asfari M, Janjic D, Meda P, et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992; 130: 167-178.
21. Stoffers DA, Ferrer J, Clarke WL, et al. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 1997; 17: 138-139.
22. Lindner T, Gragnoli C, Furuta H, et al. Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. J Clin Invest 1997; 100: 1400-1405.
23. Lohrum MAE, Ashcroft M, Kubbutat MHG, et al. Identification of a cryptic nucleolar-localization signal in MDM2. Nat Cell Biol 2000; 2: 179-181.
24. Maeda Y, Hwang-Verslues WW, Wei G, et al. Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4a (HNF4a) gene. Biochem J 2006; 400: 303-313.
25. Lee YK, Dell H, Dowhan DH, et al. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol 2000; 20: 187-195.
26. Iordanidou P, Aggelidou E, Demetriades C, et al. Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha. J Biol Chem 2005; 280: 21810-21819.