Simulation of arrhythmogenic effect of rogue RyRs in failing heart by using a coupled model

Computational and Mathematical Methods in Medicine

Volumn 2012, Issue , 2012, Pages

  Lu, Luyao ^a   Xia, Ling ^b   Zhu, Xiuwei ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; ELECTROPHYSIOLOGY;

ACTION POTENTIALS; CELLULAR ELECTROPHYSIOLOGY; CELLULAR LEVELS; COUPLED MODELING; DISTRIBUTION DENSITY; ELECTROPHYSIOLOGICAL MODELS; MEMBRANE POTENTIALS; REACTION DIFFUSION SYSTEMS;

HEART;

CALCIUM ION; RYANODINE RECEPTOR; CALCIUM;

ACTION POTENTIAL; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DYNAMICS; HEART ELECTROPHYSIOLOGY; HEART FAILURE; MATHEMATICAL MODEL; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; SIMULATION; CHEMISTRY; COMPUTER SIMULATION; CYTOLOGY; DIFFUSION; ELECTROPHYSIOLOGY; HEART ARRHYTHMIA; HEART VENTRICLE; HUMAN; METABOLISM; METHODOLOGY; MUSCLE CELL; STATISTICAL MODEL; THEORETICAL MODEL; TIME;

ACTION POTENTIALS; ARRHYTHMIAS, CARDIAC; CALCIUM; COMPUTER SIMULATION; DIFFUSION; ELECTROPHYSIOLOGY; HEART FAILURE; HEART VENTRICLES; HUMANS; MEMBRANE POTENTIALS; MODELS, STATISTICAL; MODELS, THEORETICAL; MUSCLE CELLS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TIME FACTORS;

EID: 84867767006     PISSN: 1748670X     EISSN: 17486718     Source Type: Journal    
DOI: 10.1155/2012/183978     Document Type: Article

References (35)

1. Cheng H., Lederer W. J., Cannell M. B., Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 1993 262 5134 740 744 2-s2.0-0027426069 (Pubitemid 23350693)
2. 2+ release units and couplons in skeletal and cardiac muscles. Biophysical Journal 1999 77 3 1528 1539 2-s2.0-0032839459
3. Lakatta E. G., Guarnieri T., Spontaneous myocardial calcium oscillations: are they linked to ventricular fibrillation? Journal of Cardiovascular Electrophysiology 1993 4 4 473 489 2-s2.0-0027234743 (Pubitemid 23241860)
4. Lipp P., Niggli E., Submicroscopic calcium signals as fundamental events of excitation-contraction coupling in guinea-pig cardiac myocytes. Journal of Physiology 1996 492 1 31 38 2-s2.0-0029963234 (Pubitemid 26123630)
5. + current in guinea-pig cardiac myocytes. Journal of Physiology 2002 542 2 383 393 2-s2.0-0037101561 10.1113/jphysiol.2001.013382 (Pubitemid 35190301)
6. 2+ efflux theory and practice. Progress in Biophysics and Molecular Biology 2006 90 1-3 172 185 2-s2.0-28344452166 10.1016/j.pbiomolbio.2005.06.010 (Pubitemid 41721050)
7. Xie W., Brochet D. X. P., Wei S., Wang X., Cheng H., Deciphering ryanodine receptor array operation in cardiac myocytes. Journal of General Physiology 2010 136 2 129 133 2-s2.0-77955048282 10.1085/jgp.201010416
8. 2+ leak in normal and failing rabbit ventricular myocytes. Journal of Physiology 2010 588 23 4743 4757 2-s2.0-78649718110 10.1113/jphysiol.2010.197913
9. Santiago D. J., Curran J. W., Bers D. M., Lederer W. J., Stern M. D., Ríos E., Shannon T. R., Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophysical Journal 2010 98 10 2111 2120 2-s2.0-77952750943 10.1016/j.bpj.2010.01.042
10. Baddeley D., Jayasinghe I. D., Lam L., Rossberger S., Cannell M. B., Soeller C., Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America 2009 106 52 22275 22280 2-s2.0-76049092344 10.1073/pnas.0908971106
11. 2+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. Journal of Physiology 2010 588 23 4731 4742 2-s2.0-78649686888 10.1113/jphysiol.2010.193375
12. Brochet D. X. P., Xie W., Yang D., Cheng H., Lederer W. J., Quarky calcium release in the heart. Circulation Research 2011 108 2 210 218 2-s2.0-79251592504 10.1161/CIRCRESAHA.110.231258
13. 2+ leak in intact ventricular myocytes from rabbits in heart failure. Circulation Research 2003 93 7 592 594 2-s2.0-0141752833 10.1161/01.RES.0000093399.11734.B3 (Pubitemid 37222154)
14. Lu L., Xia L., Ye X., Cheng H., Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure. Physical Biology 2010 7 2 2-s2.0-77954111650 10.1088/1478-3975/7/2/ 026005 026005
15. 2+ sparks. Biophysical Journal 2001 80 1 88 102 2-s2.0-0035138204
16. Izu L. T., Wier W. G., Balke C. W., Evolution of cardiac calcium waves from stochastic calcium sparks. Biophysical Journal 2001 80 1 103 120 2-s2.0-0035132882
17. Ten Tusscher K. H. W. J., Panfilov A. V., Alternans and spiral breakup in a human ventricular tissue model. American Journal of Physiology 2006 291 3 H1088 H1100 2-s2.0-33748419943 10.1152/ajpheart.00109.2006 (Pubitemid 44343652)
18. Lehnart S. E., Wehrens X. H. T., Marks A. R., Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochemical and Biophysical Research Communications 2004 322 4 1267 1279 2-s2.0-4444367635 10.1016/j.bbrc.2004.08.032 (Pubitemid 39164656)
19. 2+ leak in heart failure. Circulation Research 2005 97 12 1314 1322 2-s2.0-31444444347 10.1161/01.RES.0000194329.41863.89
20. Nattel S., Maguy A., Le Bouter S., Yeh Y. H., Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiological Reviews 2007 87 2 425 456 2-s2.0-34248595219 10.1152/physrev.00014.2006 (Pubitemid 47084677)
21. 2+-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation 1995 92 11 3220 3228 2-s2.0-0028882650
22. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circulation Research 1993 73 2 379 385 2-s2.0-0027237887 (Pubitemid 23212118)
23. Tomaselli G. F., Zipes D. P., What causes sudden death in heart failure? Circulation Research 2004 95 8 754 763 2-s2.0-6344292527 10.1161/01.RES. 0000145047.14691.db (Pubitemid 39390577)
24. Li G. R., Lau C. P., Ducharme A., Tardif J. C., Nattel S., Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. American Journal of Physiology 2002 283 3 H1031 H1041 2-s2.0-0036352059
25. Näbauer M., Beuckelmann D. J., Überfuhr P., Steinbeck G., Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 1996 93 1 168 177 2-s2.0-0030049208 (Pubitemid 26006581)
26. Valdivia C. R., Chu W. W., Pu J., Foell J. D., Haworth R. A., Wolff M. R., Kamp T. J., Makielski J. C., Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. Journal of Molecular and Cellular Cardiology 2005 38 3 475 483 2-s2.0-14744290314 10.1016/j.yjmcc.2004.12.012 (Pubitemid 40331938)
27. 2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 1999 99 5 641 648 2-s2.0-0033537359 (Pubitemid 29077705)
28. Sipido K. R., Volders P. G. A., Vos M. A., Verdonck F., Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovascular Research 2002 53 4 782 805 2-s2.0-0036199347 10.1016/S0008-6363(01)00470-9 (Pubitemid 34261018)
29. Shamraj O. I., Grupp I. L., Grupp G., Melvin D., Gradoux N., Kremers W., Lingrel J. B., De Pover A., Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts. Cardiovascular Research 1993 27 12 2229 2237 2-s2.0-0027763557 (Pubitemid 24034739)
30. Baker D. W., Einstadter D., Thomas C., Cebul R. D., Mortality trends for 23,505 medicare patients hospitalized with heart failure in Northeast Ohio, 1991 to 1997. American Heart Journal 2003 146 2 258 264 2-s2.0-0042627944 10.1016/S0002-8703(02)94784-8 (Pubitemid 36951769)
31. Kubalova Z., Terentyev D., Viatchenko-Karpinski S., Nishijima Y., Györke I., Terentyeva R., Da Cuñha D. N. Q., Sridhar A., Feldman D. S., Hamlin R. L., Carnes C. A., Györke S., Abnormal intrastore calcium signaling in chronic heart failure. Proceedings of the National Academy of Sciences of the United States of America 2005 102 39 14104 14109 2-s2.0-25444462517 10.1073/pnas.0504298102 (Pubitemid 41377710)
32. Roden D. M., A surprising new arrhythmia mechanism in heart failure. Circulation Research 2003 93 7 589 591 2-s2.0-0141640884 10.1161/01.RES. 0000095382.50153.7D (Pubitemid 37222153)
33. Pogwizd S. M., Bers D. M., Cellular basis of triggered arrhythmias in heart failure. Trends in Cardiovascular Medicine 2004 14 2 61 66 2-s2.0-1542613385 10.1016/j.tcm.2003.12.002 (Pubitemid 38340848)
34. 2+ handling in heart failure. Journal of Clinical Investigation 2005 115 3 556 564 2-s2.0-14644426524 10.1172/JCI200524159 (Pubitemid 40322225)
35. Marx S. O., Reiken S., Hisamatsu Y., Jayaraman T., Burkhoff D., Rosemblit N., Marks A. R., PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 2000 101 4 365 376 2-s2.0-0034640113