Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes

Biophysical Journal

Volumn 98, Issue 10, 2010, Pages 2111-2120

  Santiago, Demetrio J ^a   Curran, Jerald W ^a   Bers, Donald M ^b   Lederer, W J ^c   Stern, Michael D ^d   Ríos, Eduardo ^a   Shannon, Thomas R ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77952750943     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.01.042     Document Type: Article

References (35)

1. Cheng, H., W. J. Lederer, and M. B. Cannell. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 262:740-744. (Pubitemid 23350693)
2. 2+ release units and couplons in skeletal and cardiac muscles. Biophys. J. 77:1528-1539.
3. Bers, D. M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd Ed. Kluwer Academic, Dordrecht, The Netherlands.
4. 2+ efflux theory and practice. Prog. Biophys. Mol. Biol. 90:172-185.
5. 2+ sparks in frog skeletal muscle. J. Physiol. 502:3-11.
6. + current in guinea-pig cardiac myocytes. J. Physiol. 542:383-393.
7. Shannon, T. R., D. M. Bers, ..., E. Niggli. 2005. Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium. 38:497-505.
8. Lipp, P., and E. Niggli. 1996. Submicroscopic calcium signals as fundamental events of excitation-contraction coupling in guinea-pig cardiac myocytes. J. Physiol. 492:31-38. (Pubitemid 26123630)
9. 2+ sparks and embers of mammalian muscle. Properties of the sources. J. Gen. Physiol. 122:95-114.
10. 2+ leak-load relationship. Circ. Res. 91:594-600.
11. Curran, J., M. J. Hinton, ..., T. R. Shannon. 2007. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium, leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ. Res. 100:391-398. (Pubitemid 46272411)
12. Györke, S., V. Lukyanenko, and I. Györke. 1997. Dual effects of tetracaine on spontaneous calcium, release in rat ventricular myocytes. J. Physiol. 500:297-309. (Pubitemid 27193067)
13. Shannon, T. R., K. S. Ginsburg, and D. M. Bers. 2000. Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes. Biophys. J. 78:322-333.
14. Shannon, T. R., and D. M. Bers. 1997. Assessment of intra-SR free [Ca] and buffering in rat heart. Biophys. J. 73:1524-1531.
15. 2+ sparks of frog skeletal muscle. J. Gen. Physiol. 114; 31-48.
16. 2+ in mammalian, and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling? J. Gen. Physiol. 124:409-428.
17. Ríos, E., N. Shirokova, ...,A. González. 2001. A. preferred amplitude of calcium sparks in skeletal muscle. Biophys. J. 80:169-183. (Pubitemid 32108173)
18. 2+ sparks. Biophys. J. 82: 2396-2414.
19. Harkins, A. B., N. Kurebayashi, and S. M. Baylor. 1993. Resting myoplasmic free calcium in frog skeletal muscle fibers estimated with fluo-3. Biophys. J. 65:865-881.
20. 2+]i during caffeine contractures in rabbit cardiac myocytes. J. Physiol. 453:591-608.
21. Suko, J., F. Winkler,..., G. Hellmann. 1976. Aspects of the mechanism of action of local anesthetics on the sarcoplasmic reticulum, of skeletal muscle. Biochim. Biophys. Acta. 443:571-586.
22. 2+ loss in cardiac muscle: different efficiencies of different energy sources. Cardiovasc Res. 83:89-96.
23. 2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor channels under near-physiological ionic conditions. J. Gen. Physiol. 122:407-417.
24. 2+ reserve. Circ. Res. 93:40-45.
25. 2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys. J. 83:59-78.
26. 2+ release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle. J. Cell Biol. 120: 969-980.
27. Marx, S. O., J. Gaburjakova, ..., A. R. Marks. 2001. Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res. 88:1151-1158. (Pubitemid 34132515)
28. Marx, S. O., S. Reiken,..., A. R. Marks. 2000. PKa phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 101:365-376.
29. 2+ leak in intact ventricular myocytes from, rabbits in heart failure. Circ. Res. 93:592-594.
30. Kushmerick, M. J., and R. J. Podolsky. 1969. Ionic mobility in muscle cells. Science. 166:1297-1298.
31. Romani, A. M., and A. Scarpa. 2000. Regulation of cellular magnesium. Front. Biosci. 5:D720-D734.
32. 2+ across the sarcoplasmic reticulum of guinea-pig cardiac cells during excitation-contraction coupling. J. Physiol. 435:605-630.
33. 2+ binding and diffusion, during activation of frog skeletal, muscle. J. Gen. Physiol. 112:297-316.
34. Post, J. A., and G. A. Langer. 1992. Sarcolemmal calcium, binding sites in heart: I. Molecular origin, in "gas-dissected" sarcolemma. J. Membr. Biol. 129:49-57.
35. Balke, C. W., T. M. Egan, and W. G. Wier. 1994. Processes that remove calcium from the cytoplasm during excitation-contraction coupling in intact rat heart cells. J. Physiol. 474:447-462.