An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36251-36257

  Wurzburg, Beth A ^a   Kim, Beomkyu ^a   Tarchevskaya, Svetlana S ^a   Eggel, Alexander ^b   Vogel, Monique ^b   Jardetzky, Theodore S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIC RESPONSE; BINDING CONFORMATIONS; BINDING STATE; BIOCHEMICAL PROPERTIES; C-TERMINAL DOMAINS; CLOSED FORM; CONFORMATIONAL FLEXIBILITY; CRYSTAL FORMS; DISULFIDE BONDS; FC-RECEPTORS; HEAVY CHAIN; HIGH AFFINITY; HYDROPHOBIC POCKETS; INTERMEDIATE STATE; RECEPTOR BINDING; SELECTIVE BLOCKING;

COVALENT BONDS;

CONFORMATIONS;

CYSTEINE; IMMUNOGLOBULIN FC 3-4 FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DARPIN E2_79; MUTANT PROTEIN; OMALIZUMAB; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG PROTEIN BINDING; HINGE REGION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECEPTOR BINDING;

AMINO ACID SUBSTITUTION; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL, HUMANIZED; DISULFIDES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, IGE;

EID: 84867765150     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.407502     Document Type: Article

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