Interleukin-1α gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 8, 2012, Pages 1379-1385

  Zupan, Janja ^a   Pristovšek, Nuša ^a   Mencej Bedrač, Simona ^a   Komadina, Radko ^b   Preželj, Janez ^c   Marc, Janja ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b General Hospital Celje   (Slovenia)

^c UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Bone; Il 1 ; Inflammation; Osteoporosis; rs17561; rs2071375

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CARBOXY TERMINAL TELOPEPTIDE; INTERLEUKIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

AGED; ARTICLE; BONE DENSITY; BONE TISSUE; BONE TURNOVER; CONTROLLED STUDY; FEMALE; FEMUR NECK; FRAGILITY FRACTURE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HIP FRACTURE; HUMAN; HUMAN TISSUE; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; SLOVENIA; STATISTICAL SIGNIFICANCE;

AGE FACTORS; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BONE DENSITY; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIP FRACTURES; HUMANS; INTERLEUKIN-1ALPHA; MALE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; POLYMORPHISM, SINGLE NUCLEOTIDE; SLOVENIA;

EID: 84867761622     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2011-0589     Document Type: Article

References (31)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference. South Med J 2001;94:569-73.
2. Lencel P, Magne D. Inflammaging: the driving force in osteoporosis? Med Hypotheses 2010;76:317-21.
3. Mundy GR. Osteoporosis and inflammation. Nutr Rev 2007;65:S147-51.
4. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002;23:90-119.
5. Pacifici R, Rifas L, Teitelbaum S, Slatopolsky E, McCracken R, Bergfeld M, et al. Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci USA 1987;84:4616-20.
6. Hustmyer FG, Walker E, Yu XP, Girasole G, Sakagami Y, Peacock M, et al. Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis. J Bone Miner Res 1993;8:51-9.
7. Khosla S, Peterson JM, Egan K, Jones JD, Riggs BL. Circulating cytokine levels in osteoporotic and normal women. J Clin Endocrinol Metab 1994;79:707-11.
8. Kim JG, Ku SY, Lim KS, Jee BC, Suh CS, Kim SH, et al. Cytokine production by whole blood cells: relationship to interleukin gene polymorphism and bone mass. J Korean Med Sci 2005;20:1017-22.
9. Zarrabeitia MT, Riancho JA, Amado JA, Napal J, Gonzalez-Macias J. Cytokine production by peripheral blood cells in postmenopausal osteoporosis. Bone Miner 1991;14:161-7.
10. Ralston SH. Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis. J Bone Miner Res 1994;9:883-90.
11. Balla B, Kosa JP, Kiss J, Borsy A, Podani J, Takacs I, et al. Different gene expression patterns in the bone tissue of aging postmenopausal osteoporotic and non-osteoporotic women. Calcif Tissue Int 2008;82:12-26.
12. Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG, et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 2008;371:1505-12.
13. Rivadeneira F, Styrkarsdottir U, Estrada K, Halldorsson BV, Hsu YH, Richards JB, et al. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009;41:1199-206.
14. Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med 2008;358:2355-65.
15. Knudsen S, Harslof T, Husted LB, Carstens M, Stenkjaer L, Langdahl BL. The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures. Calcif Tissue Int 2007;80:21-30.
16. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
17. National Center for Biotechnology Information. [cited 2011 Jun]. Available from: http://www.ncbi.nlm.nih.gov/projects/SNP/snp-ref.cgi?showRare= on&chooseRs=all&go=Go&locusId=3552.
18. Videman T, Saarela J, Kaprio J, Nakki A, Levalahti E, Gill K, et al. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum 2009;60:470-81.
19. Rose AB. Intron-mediated regulation of gene expression. Curr Top Microbiol Immunol 2008;326:277-90.
20. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, Kel O V, et al. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 1998;26:362-7.
21. Hewitt J, Lu X, Gilbert L, Nanes MS. The muscle transcription factor MyoD promotes osteoblast differentiation by stimulation of the Osterix promoter. Endocrinology 2008;149:3698-707.
22. Sezgin M, Erdal ME, Altintas ZM, Ankarali HC, Barlas IO, Turkmen E, et al. Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. Clin Invest Med 2007;30:E86-92.
23. Gordon A, Kiss-Toth E, Stockley I, Eastell R, Wilkinson JM. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum 2008;58:3157-65.
24. Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, et al. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis Rheum 2008;58:1947-57.
25. Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, et al. The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. J Periodontol 2007;78:2311-8.
26. Logar DB, Komadina R, Prezelj J, Ostanek B, Trost Z, Marc J. Expression of bone resorption genes in osteoarthritis and in osteoporosis. J Bone Miner Metab 2007;25:219-25.
27. EMLD software. [cited 2011 Jun]. Available from: https://cge.mdanderson. org/~qhuang/Software/pub.htm.
28. *Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41:1149-60.
29. Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010;467:52-8.
30. Xu XH, Dong SS, Guo Y, Yang TL, Lei SF, Papasian CJ, et al. Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Endocr Rev 2010;31:447-505.
31. Holzer G, Von Skrbensky G, Holzer LA, Pichl W. Hip fractures and the contribution of cortical vs. trabecular bone to femoral neck strength. J Bone Miner Res 2009;24:468-74.