Probiotics for the prevention and treatment of Clostridium difficile in older patients

Age and Ageing

Volumn 41, Issue 6, 2012, Pages 706-711

  Islam, Jasmin ^a   Cohen, Jonathan ^a   Rajkumar, Chakravarthi ^a   Llewelyn, Martin J ^a  

^a BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

Author keywords

Antibiotic associated diarrhoea; Clostridium difficile; Immunesenescence; Intestinal microflora; Older people; Probiotics

Indexed keywords

FIDAXOMICIN; IMMUNOGLOBULIN; METRONIDAZOLE; PLACEBO; PROBIOTIC AGENT; VANCOMYCIN;

ABSENCE OF SIDE EFFECTS; AGED; ARTICLE; BIFIDOBACTERIUM; CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; DIARRHEA; DISEASE PREDISPOSITION; DRUG MECHANISM; GERIATRIC PATIENT; HOSPITAL INFECTION; HUMAN; IMMUNOMODULATION; INFECTION CONTROL; LACTOBACILLUS; MORBIDITY; MORTALITY; NATIONAL HEALTH SERVICE; PATHOGENESIS; PREVALENCE; PRIMARY PREVENTION; PRIORITY JOURNAL; ROOT CAUSE ANALYSIS; SACCHAROMYCES BOULARDII; SECONDARY PREVENTION; TREATMENT OUTCOME;

AGE FACTORS; AGED; AGED, 80 AND OVER; CLOSTRIDIUM DIFFICILE; DISEASE MANAGEMENT; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; MIDDLE AGED; PROBIOTICS; TERMINOLOGY AS TOPIC; TREATMENT OUTCOME;

EID: 84867760459     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afs077     Document Type: Article

References (30)

1. Health Protection Agency. Results of the mandatory Clostridium difficile reporting scheme. Available at: http://www.hpa.org.uk/web/HPAweb&HPAwebStandard/HPAweb_C/1195733750761.
2. Pépin J, Valiquette L, Alary M-E et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004; 171: 466-72.
3. Kuijper EJ, Barbut F, Brazier JS et al. Update of Clostridium difficile infection due to PCR ribotype 027 in Europe. Euro Surveill 2008; 13. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18761903.
4. Clostridium difficile Ribotyping Network (CDRN) for England and Northern Ireland 2009/10. Eurosurveillance 2008; 13. Available at: http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1296681523205.
5. van der Waaij D, Vries JMB, der Wees JECL. Colonization resistance of the digestive tract in conventional and antibiotictreated mice. J Hyg (Lond) 1971; 69: 405-11.
6. Hebuterne X. Gut changes attributed to ageing: effects on intestinal microflora. Curr Opin Clin Nutr Metab Care 2003; 6: 49-54.
7. Claesson MJ, Cusack S, O'Sullivan O et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci USA 2011; 108: 4586-591.
8. Guigoz Y, Doré J, Schiffrin EJ. The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care 2008; 11: 13-20.
9. Weiskopf D, Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl Int 2009; 22: 1041-50.
10. Jank T, Aktories K. Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol 2008; 16: 222-29.
11. Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000; 342: 390-97.
12. Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 2001; 357: 189-93.
13. Louie TJ, Miller MA, Mullane KM et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med 2011; 364: 422-31.
14. Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Micro 2011; 9: 27-38.
15. AlFaleh KM, Bassler D. Cochrane review: probiotics for prevention of necrotizing enterocolitis in preterm infants. Evid Based Child Health 2010; 5: 339-68.
16. D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002; 324: 1361.
17. Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis 2006; 6: 374-82.
18. Gao XW, Mubasher M, Fang CY, Reifer C, Miller LE. Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol 2010; 105: 1636-41.
19. Hickson M, D'Souza AL, Muthu N et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 2007; 335: 80.
20. Lönnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol 2010; 44: 106-12.
21. Conway S, Hart A, Clark A, Harvey I. Does eating yogurt prevent antibiotic-associated diarrhoea? A placebo-controlled randomised controlled trial in general practice. Br J Gen Pract 2007; 57: 953-59.
22. McFarland LV, Surawicz CM, Greenberg RN et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994; 271: 1913-8.
23. Surawicz CM, McFarland LV, Greenberg RN et al. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis 2000; 31: 1012-17.
24. Pillai A, Nelson RL. Probiotics for treatment of Clostridium difficile-associated colitis in adults. In: The Cochrane Collaboration, Pillai A, eds. Cochrane Database of Systematic Reviews. Chichester, UK: John Wiley & Sons, Ltd, 2008. Available at: http://www2.cochrane.org/reviews/en/ab004611. html.
25. Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks? Am J Clin Nutr 2006; 83: 1256-64; quiz 1446-7.
26. Besselink MG, van Santvoort HC, Buskens E et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 651-9.
27. Barraud D, Blard C, Hein F et al. Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial. Intensive Care Med 2010; 36: 1540-7.
28. Plummer S, Weaver MA, Harris JC, Dee P, Hunter J. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol 2004; 7: 59-62.
29. Surawicz CM, Elmer GW, Speelman P, McFarland LV, Chinn Jvan Belle G. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989; 96: 981-88.
30. WHO and FAO. Report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food, 2009. Available at: http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf.