NOD2 agonist promotes the production of inflammatory cytokines in VSMC in synergy with TLR2 and TLR4 agonists

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Sun, Jinghua ^a   Ding, Yanchun ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 8; MESSENGER RNA; NOD2 AGONIST; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 4 AGONIST; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IL8 PROTEIN, HUMAN; LIPOPEPTIDE; LIPOPOLYSACCHARIDE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NOD2 PROTEIN, HUMAN; PAM(3)CSK(4) PEPTIDE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CORONARY ARTERY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INNATE IMMUNITY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE CELL; CELL CULTURE; CORONARY BLOOD VESSEL; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; TIME; VASCULAR SMOOTH MUSCLE;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; CELL PROLIFERATION; CELLS, CULTURED; CORONARY VESSELS; CULTURE MEDIA; DRUG SYNERGISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NOD2 SIGNALING ADAPTOR PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867753120     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/607157     Document Type: Article

References (14)

1. Kawai T., Akira S., The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nature Immunology 2010 11 5 373 384 2-s2.0-77951260924 10.1038/ni.1863
2. Philpott D. J., Girardin S. E., Nod-like receptors: sentinels at host membranes. Current Opinion in Immunology 2010 22 4 428 434 2-s2.0-77955655337 10.1016/j.coi.2010.04.010
3. Vallejo J. G., Role of Toll-like receptors in cardiovascular diseases. Clinical Science 2011 121 1 1 10 2-s2.0-79953303630 10.1042/CS20100539
4. Davis-Dusenbery B. N., Wu C., Hata A., Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arteriosclerosis, Thrombosis, and Vascular Biology 2011 31 11 2370 2377 2-s2.0-80054926880 10.1161/ATVBAHA.111.226670
5. Inohara N., Chamaillard M., McDonald C., Nuñez G., NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annual Review of Biochemistry 2005 74 355 383 2-s2.0-17644366913 10.1146/annurev. biochem.74.082803.133347 (Pubitemid 40995511)
6. Watanabe T., Kitani A., Murray P. J., Strober W., NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nature Immunology 2004 5 8 800 808 2-s2.0-4444253690 10.1038/ni1092 (Pubitemid 39172973)
7. Uehara A., Yang S., Fujimoto Y., Fukase K., Kusumoto S., Shibata K., Sugawara S., Takada H., Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cellular Microbiology 2005 7 1 53 61 2-s2.0-12444259829 10.1111/j.1462-5822. 2004.00433.x
8. Fritz J. H., Girardin S. E., Fitting C., Werts C., Mengin-Lecreulx D., Caroff M., Cavaillon J. M., Philpott D. J., Adib-Conquy M., Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2- activating agonists. European Journal of Immunology 2005 35 8 2459 2470 2-s2.0-23844521000 10.1002/eji.200526286 (Pubitemid 41179767)
9. Morris G. E., Whyte M. K. B., Martin G. F., Jose P. J., Dower S. K., Sabroe I., Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. American Journal of Respiratory and Critical Care Medicine 2005 171 8 814 822 2-s2.0-17644390987 10.1164/rccm.200403-406OC (Pubitemid 40562711)
10. de Graaf R., Kloppenburg G., Kitslaar P. J. H. M., Bruggeman C. A., Stassen F., Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4. Microbes and Infection 2006 8 7 1859 1865 2-s2.0-33746426602 10.1016/j.micinf.2006.02.024 (Pubitemid 44128888)
11. Millette E., Rauch B. H., Kenagy R. D., Daum G., Clowes A. W., Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends in Cardiovascular Medicine 2006 16 1 25 28 2-s2.0-29444452877 10.1016/j.tcm.2005. 11.003 (Pubitemid 43012038)
12. Wang Z., Rao P. J., Castresana M. R., Newman W. H., TNF- α induces proliferation or apoptosis in human saphenous vein smooth muscle cells depending on phenotype. American Journal of Physiology 2005 288 1 H293 H301 2-s2.0-11144347760 10.1152/ajpheart.00165.2004 (Pubitemid 40023859)
13. Qi X., Li S., Li J., The prognostic value of IL-8 for cardiac events and restenosis in patients with coronary heart diseases after percutaenous coronary intervention. Japanese Heart Journal 2003 44 5 623 632 2-s2.0-24644437324 10.1536/jhj.44.623 (Pubitemid 41518963)
14. Zhao L., Lee J. Y., Hwang D. H., Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews 2011 69 6 310 320 2-s2.0-79957880832 10.1111/j.1753-4887.2011.00394.x