Development of health biotechnology in developing countries: Can private-sector players be the prime movers?

Biotechnology Advances

Volumn 30, Issue 6, 2012, Pages 1589-1601

  Abuduxike, Gulifeiya ^a,b   Aljunid, Syed Mohamed ^a,b  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

Economic growth; Health biotechnology; Health innovation system; Innovative developing countries; Private sector role; Public private partnership

Indexed keywords

BASIC RESEARCH; BIOTECHNOLOGY INDUSTRY; COMMERCIAL PRODUCTS; ECONOMIC GROWTHS; ECONOMIC STATUS; EMPLOYMENT OPPORTUNITIES; HEALTH PRODUCTS; HEALTH-CARE SYSTEM; IF THERE ARE; INNOVATION PROCESS; INNOVATION SYSTEM; INNOVATIVE PROCESS; INTERNATIONAL ORGANIZATIONS; PRIME MOVERS; PRIVATE SECTORS; PUBLIC AND PRIVATE SECTOR; PUBLIC/PRIVATE PARTNERSHIPS; SCIENCE AND TECHNOLOGY; SOUTH KOREA;

BIOTECHNOLOGY; DEVELOPING COUNTRIES; ECONOMICS; HEALTH CARE; INDUSTRY;

HEALTH;

BIOTECHNOLOGY; COMMERCIALIZATION; DEVELOPING WORLD; ECONOMIC GROWTH; EMPLOYMENT; HEALTH CARE; HEALTH IMPACT; INNOVATION; INTERNATIONAL ORGANIZATION; PRIVATE SECTOR; PUBLIC-PRIVATE PARTNERSHIP; SOCIOECONOMIC STATUS; TECHNOLOGICAL DEVELOPMENT;

BIOTECHNOLOGY; DEVELOPING COUNTRY; ECONOMIC DEVELOPMENT; ECONOMICS; HEALTH CARE DELIVERY; HUMAN; METHODOLOGY; ORGANIZATION; ORGANIZATION AND MANAGEMENT; REVIEW;

BIOTECHNOLOGY; DELIVERY OF HEALTH CARE; DEVELOPING COUNTRIES; ECONOMIC DEVELOPMENT; HUMANS; ORGANIZATIONAL INNOVATION; PRIVATE SECTOR;

BRAZIL; INDIA; SOUTH KOREA;

EID: 84867728783     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2012.05.002     Document Type: Review

References (95)

1. Abhishek K. Country focus: Indian Biotech Bazaar: a swot analysis. Biotechnol J 2007, 2:543-545.
2. Akira H. The Brazilian vaccine manufacturers' perspective and its current status. Biologicals 2009, 37:173-176.
3. Bong M.Y. Korean experience. Presentation and contribution on case study on South Korea as part of the Malaysia AMI-STI project 2010, Professor of Seoul National University.
4. Calestous J., Lee Y.C. Reinventing global health: the role of science, technology, and innovation. Millennium Project. Lancet 2005, 365:1105-1107.
5. Calestous J., Lee Y.C. Innovation: applying knowledge in development. UN Millennium Project, Task Force on Science, Technology and Innovation. United Nations Development Programme 2005.
6. Cheri G. Product development partnerships (PDPs): lessons from PDPs established to develop new health technologies for neglected diseases 2010, Human Development Resource Centre.
7. Christina C.M., Monali R., Sharon C., Michelle L., Jan E.C., Jennifer C., et al. A survey of South-North health biotech collaboration. Nat Biotechnol 2009, 27(3):229-232.
8. Daar A.S., Thorsteinsdóttir H., Martin D.K., Smith A.C., Nast S., Singer P.A. Top 10 biotechnologies for improving health in developing countries. Nat Gen 2002, 32:229-232.
9. Daar A.S., Kathryn B., Deepa L.P., Peter A.S. How can developing countries harness biotechnology to improve health?. BMC Publ Health 2007, 7:346. Available online at: http://www.biomedcentral.com/1471-2458/7/346.
10. Deok S.Y. Korea's National Innovation System and the Science and Technology Policy Science and Technology Policy Institute (STEPI) Available online at:. http://www.unesco.org/science/psd/thm_innov/forums/korea.pdf.
11. Dong W.S., Martin K. Universities, clusters, and innovation systems: the case of Seoul, Korea. World Dev 2007, 35(6):991-1004.
12. Eduardo M.A., José E.C. Less-developed countries and innovation in health: notes and data about the Brazilian case. 2ème Colloque des Economistes Français de la Santé 2001.
13. Elizabeth Z. Public-private partnerships for product development: financial, scientific and managerial issues as challenges to future success. Report for Commission on Intellectual Property Rights, Innovation and Public Health 2005, World Health Organization.
14. Ernest and Young Beyond borders: global biotechnology report Available online at:. http://www.eycom.ch/publications/items/biotech_report02_exec/en.pdf.
15. Ernest and Young Beyond borders: the global prospective. global biotechnology report Available online at:. http://www.successformula.ru/file.php/1/stuff/Biotechnology_Beyond_Borders_2008.pdf.
16. Ernest and Young Beyond borders: the new normal. Global biotechnology report Available online at:. http://www.tweetetesneurones.com/medias/doc/Beyondborders2010.pdf.
17. Global Forum for Health Research Monitoring financial flows for health research 2009: behind the global numbers. Global Forum for Health Research 2009, October; Geneva, Switzerland.
18. Guimarães R., Leonor M.P.S., Antonia A.T., Suzanne J.S. Defining and implementing a National Policy for Science, Technology, and Innovation in Health: lessons from the Brazilian experience. Cad Saúde Pública Rio de Janeiro 2006, 22(9):1775-1794.
19. Harris R., Mahoney R. Pathways for enhancing access to health technologies through improved IP management: the MIHR Programme for Health Innovation (MPHI). The centre for Management of Intellectual Property in Health Research and Development, United Kingdom 2005.
20. IMF World economic outlook: slowing growth, rising risks. International Monetary Fund 2011.
21. Janice M.M. The tiger awakens: the tumultuous transformation of India's patent system and the rise of Indian pharmaceutical innovation. University of Pittsburgh School of Law Working Paper Series. Paper 43 2006.
22. Jason K. Biotechnology innovations in developing nations. Biotechnology Health Care, Business 2006, 55-58.
23. Jean E.A. Promoting innovation in developing countries: a conceptual framework 2004, World Bank Institute.
24. Jean O.L., Margaret M. Statistical trends in pharmaceutical research for poor countries 2005, WHO, Available online at: http://www.who.int/intellectualproperty/studies/Lanjouw_Statistical%20Trends.pdf.
25. John O.M. Health innovation system in developing countries: strategies for building scientific and technological capacities 2005, WHO.
26. Jonathan A., Christopher K. Global health research: India research and collaboration in the new geography of science 2009, Evidence Ltd, a Thomson Reuters company, June.
27. Jonathan A., Christopher K., Vinay S. Global health research: India research and collaboration in the new geography of science 2009, Evidence Ltd, a Thomson Reuters company, October.
28. Joonghae S. Korea's innovation system: challenges and new policy agenda. United Nations University-Institute for New Technology (UNU/INTECH) discussion papers 2001, the Netherlands. Available online at: http://www.intech.unu.edu. 1564-8370.
29. Joseph W., Uyen Q., Thorsteinsdóttir H., Peter A.S., Abdallah S.D. South Korean biotechnology-a rising industrial and scientific powerhouse. Nat Biotechnol Suppl 2004, 22.
30. Justin C., Hassan M., Kumar P., Jennifer H., Peter A.S. Indian vaccine innovation: the case of Shantha Biotechnics. Glob Heal 2011, 7:9.
31. Kate H., Katharina L. National innovation systems: a case study of South Korea and Brazil. Labour 2004, 1-12.
32. Kent B., Walt G. Global public-private partnerships: part I-a new development in health?. Bull World Health Organ 2000, 78:4. [WHO].
33. Krattiger A.F. Public-private partnerships for efficient proprietary biotech science management and transfer, and increased private sector investments. A briefings paper with six proposals commissioned by UNIDO. IP Strategy Today. No. 4-2002 Available online at:, (Accessed on 18th February 2011). http://www.biodevelopments.org/ip/ipst4n.pdf.
34. Lundvall B.A. National system of innovation: toward a theory of innovation and interactive learning 2010, Anthem Press, London.
35. Lundvall B.A., Johnson B., Andersen E.S., Dalum B. National systems of production, innovation and competence building. Res Policy 2002, 31:213-231.
36. Mahoney RT. Building Product Innovation Capability in Health. In: Krattiger A, Mahoney RT, Nelsen L, et al., editors. Intellectual property management in health and agricultural innovation: a handbook of best practices 2007. MIHR: Oxford, U.K., and PIPRA: Davis, U.S.A. Available online at http://www.ipHandbook.org.
37. Mahoney R.T. Product development partnerships: case studies of a new mechanism for health technology innovation. Health Res Policy Syst 2011, 9:33. Available at: http://www.health-policy-systems.com/content/9/1/33 (Accessed on 11th Jan 2012).
38. Mahoney R.T., Morel C.M. A global health innovation system (GHIS). Innov Strategy Today 2006, 2(1):1.1-1.12. Available at: www.biodevelopments.org/innovation/index.htm.
39. Mahoney R., Lee K., Yun M. Intellectual property, drug regulation, and building product innovation capability in biotechnology: the case of Hepatitis B vaccine in Korea. Innov Strategy Today 2005, 1(2):33-44. Online available at: www.biodevelopments.org/innovation/index.htm.
40. Marcela F., Thorsteinsdóttir H., Uyen Q., Peter A.S., Abdallah S.D. The scientific muscle of Brazil's health biotechnology. Nat Biotechnol 2004, 22. [SUPPLEMENT].
41. Maria I.S., Bruce B.D., Gulnar A.e S., Ana M.M., Carlos A.M., Sandhi M.B., et al. Chronic non-communicable diseases in Brazil: burden and current challenges. Lancet 2011, 377:1949-1961.
42. Mashelkar R.A. Nation building through science and technology: a developing world perspective. 10th Zuckermann lecture. Innov Strategy Today 2005, 1(1):16-32. www.biodevelopments.org/innovation/index.htm.
43. MIHR Innovation in developing countries to meet health needs: experiences of China, Brazil, South Africa and India. MIHR report to CIPIH 2005, The Centre for Management of IP in Health R&D.
44. MOEST R&D budget allocation plan 2010, National Science & Technology Council.
45. Moisés G., Suzanne J.S. The Brazilian Ministry of Health and science, technology, and innovation policy. Cad Saúde Pública Rio de Janeiro 2006, 22(3):470-471.
46. Moran M., Ropars A.L., Guzman J., Diaz J., Garrison C. The new landscape of neglected disease drug development 2005, The Wellcome Trust, London, Available online at: http://www.wellcome.ac.uk/stellent/groups/corporatesite/@msh_publishing_group/documents/web_document/wtx026592.pdf.
47. Moran M., Guzman J., Ropars A.L., Illmerb A. The role of product development partnerships in research and development for neglected diseases. Int Health 2010, 2:114-122.
48. Morel C., Tara A., Denis B., Ajit D., Christopher E. Health innovation networks to help developing countries address neglected diseases. Science 2005, 309:401-404.
49. Morel C., Broun D., Dangi A., Elias C., Gardner C., Gupta R.K., et al. Health innovation in developing countries to address diseases of the poor. Innov Strategy Today 2005, 1(1):1-15. Available online at: www.biodevelopments.org/innovation/index.htm.
50. Nandini K.K., Uyen Q., Thorsteinsdóttir H., Hemlatha S., Abdallah S.D., Peter A.S. Indian biotechnology rapidly evolving and industry led. Nat Biotechnol Suppl 2004, 22:C31-DC36.
51. National Biotechnology Development Strategy Department of Biotechnology, Ministry of Science and Technology, Government of India. Draft Available online at:. http://dbtindia.nic.in/biotechstrategy/Biotech%20strategy.doc.
52. NCDs policy brief-India Available online at:, Feb (Accessed 12Jan 2012). http://siteresources.worldbank.org/SOUTHASIAEXT/Resources/223546-1296680097256/7707437-1296680114157/NCD_IN_Policy_Feb_2011.pdf.
53. OECD OECD reviews of innovation policy: Korea 2009.
54. OECD Science and innovation: country notes Korea. Science, technology and industry outlook Available online:. http://www.oecd.org/dataoecd/41/38/46665163.pdf.
55. Padmanaban G. Growth of biotechnology in India. Curr Sci 2003, 85:712-719. Available online at: http://www.ias.ac.in/currsci/sep252003/712.pdf.
56. Parveen A. Healthcare biotechnology firms in India: evolution, structure and growth. Curr Sci 2005, 89:3.
57. Patrick N. Building biotechnology by design: role of biotechnology in development. J Commer Biotechnol 2011, 17(1):4-6.
58. Peter D. Regulating patent offices: countering pharmaceutical hegemony. SCRIPTed 2008, 5(3):501-514.
59. Prasanta K.G. The role of alliance in modern biotech industries in developing countries. Curr Sci 2004, 87(7):874-884.
60. Rahim R., Sarah E.F., Stephen M.S., Maya R.M., Abdallah S.D., Peter A.S. Brazilian health biotech-fostering crosstalk between public and private sectors. Nat Biotechnol 2008, 126(6):627-644.
61. Ridley R. Product development public-private partnerships for diseases of poverty, are there more efficient alternatives? Are there limitations?. Prepared for the workshop on IPPPH "Combating Diseases Associated with Poverty: Financing Strategies for Product Development and the Potential Role of Public-Private Partnerships, 15-16 April 2004, 2. London.
62. Robert G.R. Product development public private partnership for disease of poverty. Are there more efficient alternatives? Are there limitations? UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases 2004, London, UK.
63. Roddam N. Science, technology and the economy: an Indian perspective. Technol Soc 2008, 30:330-338.
64. Roy W. Public-private partnerships for health: their main targets, their diversity, and their future directions. Bull World Health Organ 2001, 79:713-720. [WHO].
65. Roy W., Katherine W. Combating diseases associated with poverty: financing strategies for product development and the potential role of public-private partnerships 2004, Wellcome Trust, London, United Kingdom.
66. Sachin C. Status and development of biotechnology in India: an analytical overview. Research and information system for the non-aligned and other developing countries. IRS discussion paper 2002, RIS-DP # 28/2002.
67. Sarah E.F., Stephen M.S., Siu W.W., Abdallah S.D., Peter A.S. The role of the domestic private sector in developing countries for addressing local health needs. Int J Biotechnol 2006, 8:91-102.
68. Sarah E.F., Rahim R., Stephen M.S., Monali R., Abdullah S.D., Peter A.S. India's health biotech sector at a crossroads. Nat Biotechnol 2007, 25:403-417.
69. Sarah E.F., Hannah E.K., Peter A.S. The Indian and Chinese health biotechnology industries: potential champions of global health?. Heal Aff 2008, 27(4):1029-1041.
70. Satyanarayana K. Current IP Management Issues for Health and Agriculture in India. In: Krattiger A, Mahoney RT, Nelsen L, et al., editors. Intellectual property management in health and agricultural innovation: a handbook of best practices. MIHR: Oxford, U.K., and PIPRA: Davis, U.S.A.; 2007. Available online at http://www.ipHandbook.org.
71. Stephen F. National innovation systems: overview and country cases. Knowledge flows, innovation, and learning in developing countries 2003, Center for Science, Policy, and Outcomes.
72. Suresh J., Mahima D., Hans K., Jan H. The Developing Countries Vaccine Manufacturers' Network (DCVMN) is a critical constituency to ensure access to vaccines in developing countries. Vaccine 2008, 26:1611-1615.
73. Tara A., Robyn K., Abdallah S.D., Peter A.S. Biotechnology to improve health in developing countries: a review. Mem Inst Oswaldo Cruz Rio de Janeiro 2004, 99(4):341-350.
74. The Economist Southern comfort, eastern promise: how biotechnology from poor countries can tackle local problems December 11. http://www.economist.com/node/3471269.
75. The World Bank Capitalizing on the demographic transition: tackling non-communicable diseases in South Asia 2011.
76. The World Factbook 2010 est. Washington, DC: Central Intelligence Agency, 2010. Available online at: https://www.cia.gov/library/publications/the-world-factbook/index.html.
77. The World Factbook, 2012. Washington, DC: Central Intelligence Agency, 2012. Available online at: https://www.cia.gov/library/publications/the-world-factbook/index.html.
78. Thorsteinsdótti H., Sáenz Tirso W., Singer Peter A., Daar Abdallah S. Different rhythms of health biotechnology development in Brazil and Cuba. J Bus Chem 2005, 2(3).
79. Thorsteinsdóttir H. The role of the health system in biotechnology in Brazil and Cuba. Health partnerships review: focusing collaborative efforts on research and innovation for the health of the poor 2008, 39-42.
80. Thorsteinsdóttir H., Quach U., Douglas K.M., Abdallah S.D., Peter A.S. Introduction: promoting global health through biotechnology. Nat Biotechnol Suppl 2004, 22:DC3-DC7.
81. Thorsteinsdóttir H., Quach Uyen, Abdallah S.D., Peter A.S. Conclusions: promoting biotechnology innovation in developing countries. Nat Biotechnol Suppl 2004, 22:DC48-DC52.
82. Thorsteinsdóttir H., Abdallah S.D., Peter A.S. Health biotechnology publishing takes-off in developing countries. Int J Biotechnol 2006, 8(1/2).
83. Thorsteinsdóttir H., Christina C.M., Monali R., Sharon C., Michelle L., Jan E.C., et al. South-South entrepreneurial collaboration in health biotech. Nat Biotechnol 2010, 28(5):407-416.
84. Thorsteinsdóttir H., Ray Monali, Kapoor Andrew, Daar Abdallah S. Health biotechnology innovation on a global stage. Nature reviews. Microbiology 2011, 9:137-144. www.nature.com/reviews/micro.
85. Tirso W.S., Thorsteinsdóttir H., de Souza Maria Carlota Cuba and Brazil: an important example of South-South collaboration in health biotechnology. MEDICC Rev 2010, 12.
86. Troullier P., Olliaro P., Torreele E., Orbinski J., Laing R., Ford N. Drug development for neglected diseases: a deficient market and a public health policy failure. Lancet 2002, 359:2188-2194.
87. UNCTD The biotechnology promise: capacity-building for participation of developing countries in the bioeconomy. United Nations Conference on Trade and Development. United Nations 2004, New York and Geneva.
88. UNDP Human development report 2011: human development index and its components. United Nations Development Programs 2011, New York. Available online at: http://hdrstats.undp.org/en/countries/profiles/BRA.html.
89. Unleashing entrepreneurship, making business work for the poor. United Nations Development Programme 2004, UNDP Commission on the Private Sector and Development.
90. Uyen Q., Halla T., James R., Archana B., Zoë C.A., Peter A.S., et al. Biotechnology patenting takes off in developing countries. Int J Biotechnol 2006, 8(1/2):43-58.
91. WHO WHO facilitates influenza vaccine technology transfer to developing countries 2007, World Health Organization, Available online at: http://www.who.int/mediacentre/news/notes/2007/np18/en/index.html.
92. WHO World Health Statistics, 2012 2012, World Health Organization.
93. WIPO World Intellectual Property Organization, March/April Geneva. Available Online at:. http://www.wipo.int/wipo_magazine/en/pdf/2004/wipo_pub_121_2004_03-04.pdf.
94. WIPO World Intellectual Property Organization. Issue 2007/4 Geneva. Available online at:. http://www.wipo.int/wipo_magazine/en/pdf/2007/wipo_pub_121_2007_04.pdf.
95. World Economic Forum Building on the Monterrey consensus: the growing role of public-private partnerships in mobilizing resources for development. United Nations High-level Plenary Meeting on Financing for Development 2005, Geneva.