1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuroblastic apoptosis in the subventricular zone is caused by 1-methy-4-phenylpiridinium (MPP+) converted from MPTP through MAO-B

Experimental and Toxicologic Pathology

Volumn 64, Issue 7-8, 2012, Pages 761-765

  Ito, Tsuyoshi ^a   Suzuki, Kazuhiko ^a   Uchida, Kazuyuki ^a   Nakayama, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Intracerebroventricular (icv) injection; Monoamine oxidase B (MAO B); MPP+; MPTP; Neuroblastic apoptosis

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; EPIDERMAL GROWTH FACTOR RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; SELEGILINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TISSUE; C57BL 6 MOUSE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROBLAST; NICK END LABELING; NONHUMAN; SUBVENTRICULAR ZONE;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CEREBRAL VENTRICLES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPENDYMA; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEURAL STEM CELLS; NEUROPEPTIDES; SELEGILINE;

MUS;

EID: 84867728334     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2011.01.013     Document Type: Article

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