-
1
-
-
77950476613
-
Molecular pathology of myeloproliferative neoplasms
-
Apr
-
Klco JM, Vij R, Kreisel FH, et al. Molecular pathology of myeloproliferative neoplasms. Am J Clin Pathol 2010 Apr; 133 (4): 602-15
-
(2010)
Am J Clin Pathol
, vol.133
, Issue.4
, pp. 602-615
-
-
Klco, J.M.1
Vij, R.2
Kreisel, F.H.3
-
2
-
-
70349256226
-
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
-
Jul 30
-
Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009 Jul 30; 114 (5): 937-51
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 937-951
-
-
Vardiman, J.W.1
Thiele, J.2
Arber, D.A.3
-
3
-
-
39149105615
-
Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: A consensus statement from the International Working Group for Myelofibrosis Research and Treatment
-
Feb
-
Barosi G, Mesa RA, Thiele J, et al. Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the International Working Group for Myelofibrosis Research and Treatment. Leukemia 2008 Feb; 22 (2): 437-8
-
(2008)
Leukemia
, vol.22
, Issue.2
, pp. 437-438
-
-
Barosi, G.1
Mesa, R.A.2
Thiele, J.3
-
4
-
-
84857959801
-
-
Office Of Rare Diseases Research US National Insitutes Of Health [online]. Available From URL: [Accessed 2012Mar 14]
-
Office of Rare Diseases Research, US National Insitutes of Health. Genetic and rare disease information center: myelofibrosis [online]. Available from URL: http://rare diseases.info.nih.gov/GARD/Condition/8618/Myelofibrosis. aspx [Accessed 2012Mar 14]
-
Genetic and Rare Disease Information Center: Myelofibrosis
-
-
-
5
-
-
85081766427
-
-
Orphanet [online]. Available From URL: [Accessed 2012 Mar 14]
-
Orphanet. Myelofibrosis with myeloid metaplasia [online]. Available from URL: http://www.orpha.net/consor/cgibin/OC-Exp.php?lng=EN&Expert=824 [Accessed 2012 Mar 14]
-
Myelofibrosis with Myeloid Metaplasia
-
-
-
6
-
-
80054687489
-
Clinical and laboratory features of myelofibrosis and limitations of current therapies
-
Sep
-
Gregory SA, Mesa RA, Hoffman R, et al. Clinical and laboratory features of myelofibrosis and limitations of current therapies. Clin Adv Hematol Oncol 2011 Sep; 9 (9 Suppl. 22): 1-16
-
(2011)
Clin Adv Hematol Oncol
, vol.9
, Issue.9 SUPPL. 22
, pp. 1-16
-
-
Gregory, S.A.1
Mesa, R.A.2
Hoffman, R.3
-
7
-
-
78651344350
-
Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: A single center study of 433 patients
-
Jan
-
Caramazza D, Begna KH, Gangat N, et al. Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients. Leukemia 2011 Jan; 25 (1): 82-8
-
(2011)
Leukemia
, vol.25
, Issue.1
, pp. 82-88
-
-
Caramazza, D.1
Begna, K.H.2
Gangat, N.3
-
8
-
-
79551491928
-
Philadelphia-negative classical myeloproliferative neoplasms: Critical concepts and management recommendations from European LeukemiaNet
-
Feb 20
-
Barbui T, Barosi G, Birgegard G, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 2011 Feb 20; 29 (6): 761-70
-
(2011)
J Clin Oncol
, vol.29
, Issue.6
, pp. 761-770
-
-
Barbui, T.1
Barosi, G.2
Birgegard, G.3
-
9
-
-
79952075257
-
Myeloproliferative neoplasms: Molecular pathology, essential clinical understanding, and treatment strategies
-
Feb 10
-
Tefferi A, Vainchenker W. Myeloproliferative neoplasms: molecular pathology, essential clinical understanding, and treatment strategies. J Clin Oncol 2011 Feb 10; 29 (5): 573-83
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 573-583
-
-
Tefferi, A.1
Vainchenker, W.2
-
10
-
-
79953711716
-
How i treat myelofibrosis
-
Mar 31
-
Tefferi A. How I treat myelofibrosis. Blood 2011 Mar 31; 117 (13): 3494-504
-
(2011)
Blood
, vol.117
, Issue.13
, pp. 3494-3504
-
-
Tefferi, A.1
-
12
-
-
52949089050
-
JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies
-
Aug
-
Vainchenker W, Dusa A, Constantinescu SN. JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies. Semin Cell Dev Biol 2008 Aug; 19 (4): 385-93
-
(2008)
Semin Cell Dev Biol
, vol.19
, Issue.4
, pp. 385-393
-
-
Vainchenker, W.1
Dusa, A.2
Constantinescu, S.N.3
-
13
-
-
33845348577
-
The JAK-STAT pathway: A therapeutic target in hematologicalmalignancies
-
Dec
-
Ferrajoli A, Faderl S, Ravandi F, et al. The JAK-STAT pathway: a therapeutic target in hematologicalmalignancies. Curr Cancer Drug Targets 2006 Dec; 6 (8): 671-9
-
(2006)
Curr Cancer Drug Targets
, vol.6
, Issue.8
, pp. 671-679
-
-
Ferrajoli, A.1
Faderl, S.2
Ravandi, F.3
-
14
-
-
85081762738
-
-
Incyte Corporation [online] [Accessed 2012 Feb 27]
-
Incyte Corporation. Jakafi(ruxolitinib) oral tablets: US prescribing information [online]. Available from URL: http://www.incyte.com/products/ uspijakafi.pdf [Accessed 2012 Feb 27]
-
Jakafi(ruxolitinib) Oral Tablets: US Prescribing Information
-
-
-
15
-
-
77955267882
-
-
European Medicines Agency [online] [Accessed 2012 Oct 8]
-
European Medicines Agency. Jakavi (ruxolitinib): EU summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/docs/en- GB/document-library/EPAR-Product-Information/human/002464/WC 500133223.pdf [Accessed 2012 Oct 8]
-
Jakavi (Ruxolitinib): EU Summary of Product Characteristics
-
-
-
16
-
-
77950684805
-
Preclinical characterization of the selective JAK12 Inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
-
Apr 15
-
Quintas-Cardama A, Vaddi K, Liu P, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2012 Apr 15; 115 (15): 3109-17
-
(2012)
Blood
, vol.115
, Issue.15
, pp. 3109-3117
-
-
Quintas-Cardama, A.1
Vaddi, K.2
Liu, P.3
-
17
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in myelofibrosis
-
Sep 16
-
Verstovsek S, Kantarjian H, Mesa RA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in myelofibrosis.NEngl J Med 2010 Sep 16; 363 (12): 1117-27
-
(2010)
NEngl J Med
, vol.363
, Issue.12
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
-
18
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Mar 1
-
Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012 Mar 1; 366 (9): 799-807
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
19
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Mar 1
-
Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012 Mar 1; 366 (9): 787-98
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
-
20
-
-
85081775009
-
Reductions in JAK2V617F allele burden with ruxolitinib treatment in COMFORT-II, a phase III study comparing the safety and efficacy of ruxolitinib to best available therapy (BAT) [abstract no. 6514]
-
May 20
-
Vannucchi AM, Kiladjian JJ, Gisslinger H, et al. Reductions in JAK2V617F allele burden with ruxolitinib treatment in COMFORT-II, a phase III study comparing the safety and efficacy of ruxolitinib to best available therapy (BAT) [abstract no. 6514]. J Clin Oncol 2012 May 20; 30 (15 Suppl.)
-
(2012)
J Clin Oncol
, vol.30
, Issue.15 SUPPL.
-
-
Vannucchi, A.M.1
Kiladjian, J.J.2
Gisslinger, H.3
-
21
-
-
80053014000
-
The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers
-
Shi JG, Chen X, McGee RF, et al. The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers. J Clin Pharmacol 2011Dec; 51 (12): 1644-54
-
J Clin Pharmacol 2011Dec
, vol.51
, Issue.12
, pp. 1644-1654
-
-
Shi, J.G.1
Chen, X.2
McGee, R.F.3
-
22
-
-
84859643082
-
Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms
-
Apr
-
Deshpande A, Reddy MM, Schade GO, et al. Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasms. Leukemia 2012 Apr; 26 (4): 708-15
-
(2012)
Leukemia
, vol.26
, Issue.4
, pp. 708-715
-
-
Deshpande, A.1
Reddy, M.M.2
Schade, G.O.3
-
23
-
-
79958061888
-
Oncogenic JAK1 and JAK2-activating mutations resistant to atpcompetitive inhibitors
-
Jun
-
Hornakova T, Springuel L, Devreux J, et al. Oncogenic JAK1 and JAK2-activating mutations resistant to ATPcompetitive inhibitors. Haematologica 2011 Jun; 96 (6): 845-53
-
(2011)
Haematologica
, vol.96
, Issue.6
, pp. 845-853
-
-
Hornakova, T.1
Springuel, L.2
Devreux, J.3
-
24
-
-
80051483056
-
Constitutive NFkappB activation confers interleukin 6 (IL6) independence and resistance to dexamethasome and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells
-
Aug 12
-
Yang Y, Groshong JS, Matta H, et al. Constitutive NFkappB activation confers interleukin 6 (IL6) independence and resistance to dexamethasome and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem 2011 Aug 12; 284 (32): 27988-97
-
(2011)
J Biol Chem
, vol.284
, Issue.32
, pp. 27988-27997
-
-
Yang, Y.1
Groshong, J.S.2
Matta, H.3
-
25
-
-
78049412594
-
Metabolism excretion and pharmacokinetics of [14C]-INCB018424 A Selective JAK12 Inhibitor in Humans
-
Nov
-
Shilling AD, Nedza FM, Emm T, et al. Metabolism, excretion and pharmacokinetics of [14C]-INCB018424, a selective JAK1/2 inhibitor, in humans. Drug Metab Dispos 2010 Nov; 38 (11): 2023-31
-
(2010)
Drug Metab Dispos
, vol.38
, Issue.11
, pp. 2023-2031
-
-
Shilling, A.D.1
Nedza, F.M.2
Emm, T.3
-
26
-
-
85081768256
-
Population pharmacokinetic analysis of ruxolitinib in subjects with myelofibrosis [abstract no. PI-97]
-
Mar
-
Chen X, Liu X, Peng S, et al. Population pharmacokinetic analysis of ruxolitinib in subjects with myelofibrosis [abstract no. PI-97]. Clin Pharmacol Ther 2012 Mar; 91 Suppl. 1s: S44
-
(2012)
Clin Pharmacol Ther
, vol.91
, Issue.SUPPL. 1
-
-
Chen, X.1
Liu, X.2
Peng, S.3
-
27
-
-
85081773921
-
Safety and pharmacokinetics of ruxolitinib (INC424) in healthy japanese volunteers: Placebo-controlled double-blind doseescalation phase 1 study [abstract no. 5162]
-
Nov 18
-
Ogama Y, Mineyame T, Yamamoto A, et al. Safety and pharmacokinetics of ruxolitinib (INC424) in healthy Japanese volunteers: placebo-controlled, double-blind, doseescalation phase 1 study [abstract no. 5162]. Blood 2011 Nov 18; 118 (21)
-
(2011)
Blood
, vol.118
, Issue.21
-
-
Ogama, Y.1
Mineyame, T.2
Yamamoto, A.3
-
28
-
-
77953179230
-
Effects of various degrees of renal impairment and hemodialysis on the pharmacokinetics and pharmacodynamics of INCB018424 [abstract no. PIII-53]
-
Feb
-
Shi J, Chen X, McGee R, et al. Effects of various degrees of renal impairment and hemodialysis on the pharmacokinetics and pharmacodynamics of INCB018424 [abstract no. PIII-53]. Clin Pharmacol Ther 2010 Feb; 87 Suppl. 1s: S84
-
(2010)
Clin Pharmacol Ther
, vol.87
, Issue.SUPPL. 1
-
-
Shi, J.1
Chen, X.2
McGee, R.3
-
29
-
-
85081762050
-
The effect of various degrees of hepatic dysfunction on the pharmacokinetics of INCB018424 [abstract no. PIII-59]
-
Feb
-
Chen X, Shi J, McGee R, et al. The effect of various degrees of hepatic dysfunction on the pharmacokinetics of INCB018424 [abstract no. PIII-59]. Clin Pharmacol Ther 2010 Feb; 87 Suppl. 1: S86
-
(2010)
Clin Pharmacol Ther
, vol.87
, Issue.SUPPL. 1
-
-
Chen, X.1
Shi, J.2
McGee, R.3
-
30
-
-
84861806284
-
The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers
-
Jun
-
Shi JG, Chen X, Emm T, et al. The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers. J Clin Pharmacol 2012 Jun; 52 (6): 809-18
-
(2012)
J Clin Pharmacol
, vol.52
, Issue.6
, pp. 809-818
-
-
Shi, J.G.1
Chen, X.2
Emm, T.3
-
31
-
-
80054028202
-
Long-term outcome of treatment with ruxolitinib in myelofibrosis [letter]
-
Oct 13
-
Tefferi A, Litzow MR, Pardanani A. Long-term outcome of treatment with ruxolitinib in myelofibrosis [letter]. N Engl J Med 2011 Oct 13; 365 (15): 1455-7
-
(2011)
N Engl J Med
, vol.365
, Issue.15
, pp. 1455-1457
-
-
Tefferi, A.1
Litzow, M.R.2
Pardanani, A.3
-
32
-
-
83155182714
-
Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis
-
Tefferi A, Pardanani A. Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis. Mayo Clin Proc 2011; 86 (12): 1188-91
-
(2011)
Mayo Clin Proc
, vol.86
, Issue.12
, pp. 1188-1191
-
-
Tefferi, A.1
Pardanani, A.2
-
33
-
-
85081763303
-
A phase Ib, open-label, dose-finding study of ruxolitinib in patients (pts) with primary myelofibrosis (PMF), post-polycythemia vera-myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF) and baseline platelets (PLTs) 50 to <100 · 109/l [abstract no. TPS6642]
-
May 20 (15 Suppl.)
-
Gisslinger H, McMullin MF, Jaekel N, et al. A phase Ib, open-label, dose-finding study of ruxolitinib in patients (pts) with primary myelofibrosis (PMF), post-polycythemia vera-myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF) and baseline platelets (PLTs) 50 to <100 · 109/l [abstract no. TPS6642]. J Clin Oncol 2012 May 20; 30 (15 Suppl.)
-
(2012)
J Clin Oncol
, pp. 30
-
-
Gisslinger, H.1
McMullin, M.F.2
Jaekel, N.3
-
34
-
-
84867714085
-
Preliminary safety and efficacy of ruxolitinib in patients (pts) with primary and secondary myelofibrosis (MF) with platelet counts (PC) of 50-100 · 109/L [
-
abstract no. 6630] May (15 Suppl.)
-
Talpaz M, Hamburg SI, Jamieson K, et al. Preliminary safety and efficacy of ruxolitinib in patients (pts) with primary and secondary myelofibrosis (MF) with platelet counts (PC) of 50-100 · 109/L [abstract no. 6630]. J Clin Oncol 2012 May 20; 30 (15 Suppl.)
-
(2012)
J Clin Oncol
, vol.20
, pp. 30
-
-
Talpaz, M.1
Hamburg, S.I.2
Jamieson, K.3
-
35
-
-
84875381909
-
An open-label, multicentre, expanded access study assessing the safety and efficacy of oral ruxolitinib administered to patients with primary myelofibrosis (PMF), post-polycythemia myelofibrosis (PPV-MF) or post-essential throbocythemia melofibrosis (PET-MF) [abstract no. TPS6640]
-
May (15 Suppl.)
-
le Coutre PD, Gisslinger H, Zachee P, et al. An open-label, multicentre, expanded access study assessing the safety and efficacy of oral ruxolitinib administered to patients with primary myelofibrosis (PMF), post-polycythemia myelofibrosis (PPV-MF) or post-essential throbocythemia melofibrosis (PET-MF) [abstract no. TPS6640]. J Clin Oncol 2012 May 20; 30 (15 Suppl.)
-
(2012)
J Clin Oncol
, vol.20
, pp. 30
-
-
Le Coutre, P.D.1
Gisslinger, H.2
Zachee, P.3
|