Histopathological stainings and definitions of vascular disruptions in the elderly brain

Experimental Gerontology

Volumn 47, Issue 11, 2012, Pages 834-837

  De Reuck, Jacques L ^a  

^a UNIV LILLE   (France)

Author keywords

Alzheimer disease; Cerebral amyloid angiopathy; Frontotemporal lobar degeneration; Lewy body dementia; Micro and mini bleeds; Neuropathology; Quantification techniques

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; DYE; EOSIN; HEMATOXYLIN; LUXOL FAST BLUE; PRION PROTEIN; PRUSSIAN PERL; TAR DNA BINDING PROTEIN; TAU PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN REGION; BRAIN STEM; CAPSULA INTERNA; CEREBELLUM; CEREBROVASCULAR DISEASE; CINGULATE GYRUS; FRONTAL CORTEX; GERIATRIC PATIENT; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MEDULLA OBLONGATA; MEYNERT BASAL NUCLEUS; MICROANGIOPATHY; MICROSCOPY; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PARIETAL CORTEX; PATHOGENESIS; PONS; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUANTITATIVE STUDY; SECONDARY VISUAL CORTEX; SEMIOVAL CENTER; STAINING; STANDARD; STRIATE CORTEX; TEMPORAL CORTEX; VASCULAR AMYLOIDOSIS; WHITE MATTER LESION;

AUTOPSY; BRAIN; CEREBROVASCULAR DISORDERS; HUMANS; STAINING AND LABELING;

EID: 84867725055     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.03.012     Document Type: Article

References (22)

1. Attems J., Quass M., Jellinger K.A., Lintner F. Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology. J. Neurol. Sci. 2007, 257:49-55.
2. Cordonnier C., van der Flier W.M. Brain microbleeds and Alzheimer's disease: innocent observation or key player?. Brain 2011, 134:335-344.
3. Cordonnier C., van der Flier W.M., Sluimer J.D., Leys D., Barkhof F., Scheltens P. Prevalence and severity of microbleeds in a memory setting. Neurology 2006, 66:1356-1360.
4. Cordonnier C., Al-Shari Salman R., Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analysis and standards for study design and reporting. Brain 2007, 130:1988-2003.
5. De Reuck J. The cortico-subcortical arterial angioarchitecture in human brain. Acta Neurol. Belg. 1972, 72:323-329.
6. De Reuck J., Deramecourt V., Cordonnier C., Leys D., Maurage C.A., Pasquier F. The impact of cerebral amyloid angiopathy on the occurrence of cerebrovascular lesions in demented patients with Alzheimer features: a neuropathological study. Eur. J. Neurol. 2011, 18:913-918.
7. De Reuck J., Deramecourt V., Cordonnier C., Leys D., Pasquier F., Maurage C.A. Prevalence of small cerebral bleeds in patients with a neurodegenerative dementia: a neuropathological study. J. Neurol. Sci. 2011, 300:63-66.
8. De Reuck J., Auger F., Cordonnier C., Durieux N., Bordet R., Maurage C.A., Pasquier F., Leys D. Comparison of 7.0-T T2*-magnetic resonance imaging of cerebral bleeds in post-mortem brain sections of Alzheimer patients with their neuropathological correlates. Cerebrovasc. Dis. 2011, 31:511-517.
9. De Reuck J., Caparros-Lefebvre D., Deramecourt V., Maurage C.A. Hippocampal microbleed on a post-mortem T2*-weighted gradient-echo 7.0-tesla magnetic resonance imaging?. Case Rep. Neurol. 2011, 3:223-226.
10. De Reuck J., Deramecourt V., Cordonnier C., Leys D., Pasquier F., Maurage C.A. Cerebrovascular lesions in patients with frontotemporal lobar degeneration: a neuropathological study. Neurodegener. Dis. 2012, 9:170-175.
11. Dierksen G.A., Skehan M.E., Khan M.A., et al. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann. Neurol. 2010, 68:545-548.
12. Englund E., Brun A. White matter changes in dementia of Alzheimer's type: the difference in vulnerability between cell compartments. Histopathology 1990, 16:433-439.
13. Fisher C.M. Lacunar infarcts - a review. Cerebrovasc. Dis. 1991, 1:311-320.
14. Focht A. Differential diagnosis of dementia. Geriatrics 2009, 64:20-26.
15. Goos J.D., Kester M.I., Barkhof F., Klein M., Blankenstein M.A., Scheltens P., van der Fliers W.M. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 2009, 40:3455-3460.
16. Greenberg S.M., Vernooij M.W., Cordonnier C., Viswanathan A., Al-Shari Salman R., Warach S., Launer L.J., Van Buchem M.A., Breteler M.M. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009, 8:165-174.
17. Haglund M., Sjobeck M., Englund E. Severe cerebral amyloid angiopathy characterizes an underestimated variant of vascular dementia. Dement. Geriatr. Cogn. Disord. 2004, 18:132-137.
18. Hebbrecht G., Maenhout W., De Reuck J. Comparison of trace element alterations and water content in haemorrhagic and non-haemorrhagic cerebral infarcts. Cerebrovasc. Dis. 1994, 4:412-416.
19. Humpel C. Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?. Exp. Gerontol. 2011, 46:225-232.
20. Launer L.J., Petrovitch H., Ross G.W., Markesbery W., White L.R. AD brain pathology: vascular origins? Results from the HAAS autopsy study. Neurobiol. Aging 2008, 29:1587-1590.
21. Lee S.H., Kim S.M., Yoon B.M., Roh J.K. Cortico-subcortical distribution of microbleeds is different between hypertension and cerebral amyloid angiopathy. J. Neurol. Sci. 2007, 258:111-114.
22. Nakata-Kudo Y., Mizuno T., Yamada K., Shiga K., Yoshikawa K., Mori S., Nishimura T., Nakajima K., Nakagawa M. Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than to cerebrovascular disease. Dement. Geriatr. Cogn. Disord. 2006, 22:8-14.