The problem is obvious, the solution is not: Numbers do matter in cardiac cell therapy!

Cardiovascular Research

Volumn 96, Issue 2, 2012, Pages 208-209

  Müller Ehmsen, Jochen ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1ALPHA;

APOPTOSIS; CARDIAC CELL THERAPY; CELL DEATH; CELL HOMING; CELL PROLIFERATION; CELL PROTECTION; CELL REGENERATION; CELL SURVIVAL; CELL THERAPY; EDITORIAL; EMBRYONIC STEM CELL; HEART FUNCTION; MESENCHYMAL STEM CELL TRANSPLANTATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ANIMALS; FEMALE; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION;

EID: 84867701585     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs202     Document Type: Editorial

References (11)

1. Marelli D, Desrosiers C, el Alfy M, Kao RL, Chiu RC. Cell transplantation for myocardial repair: an experimental approach. Cell Transplant 1992;1:383-390.
2. Müller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI et al. Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation 2002;105: 1720-1726.
3. Tongers J, Losordo DW, Landmesser U. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J 2011;32: 1197-1206.
4. Müller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI et al. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol 2002;34:107-116.
5. Müller-Ehmsen J, Krausgrill B, Burst V, Schenk K, Neisen UC, Fries JW et al. Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol 2006;41: 876-884.
6. Tossios P, Krausgrill B, Schmidt M, Fischer T, Halbach M, Fries JW et al. Role of balloon occlusion for mononuclear bone marrow cell deposition after intracoronary injection in pigs with reperfused myocardial infarction. Eur Heart J 2008;29: 1911-1921.
7. Pasha Z,Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res 2008;77:134-142.
8. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9:1195-1201.
9. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007;25: 1015-1024.
10. Hu S, Huang M, Nguyen PK, Gong Y, Li Z, Jia F et al. Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation 2011;124:S27-S34.
11. Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009;4:313-323.